GPR183 contributes to renal macrophage infiltration and fibrosis in kidney injury. [PDF]
Zhang Q +6 more
europepmc +1 more source
ATP itself is able to undergo liquid–liquid phase separation in the presence of the macromolecular crowding agent PEG and physiological ATP concentrations are sufficient for phase separation in the presence of mM Mg2+ and crowders, mimicking intracellular conditions.
Robert Dec +2 more
wiley +1 more source
Spermidine biosynthesis by hypervirulent <i>Francisella tularensis</i> promotes fitness and salvages adenine. [PDF]
Yue Y +6 more
europepmc +1 more source
A Cytosine‑Bulged (3+1) Hybrid G‑Quadruplex Formed by the Chicken DNA Replication Origin
The first high‐resolution structure of an OGRE‐derived G‐quadruplex from the chicken β‐globin replication origin reveals an intramolecular three‐layer (3+1) hybrid fold with a cytosine bulge and an unprecedented 5'‐outer‐quartet anti guanine, creating a distinctive surface for molecular recognition.
Yingying You +13 more
wiley +1 more source
Inhibition of purine nucleoside and nucleobase transporters by tyrosine kinase inhibitors. [PDF]
Shahid N +5 more
europepmc +1 more source
Raman Optical Activity as a Tool to Monitor Polynucleotide Conformation in Solutions
Raman optical activity (ROA) studies of nucleic acids have been hindered by limited computational tools to link the spectra to the structure. The study shows that accurate density functional simulations are possible for model nucleotides, bringing more information about molecular geometry and dynamics in solutions.
Mohammed Siddhique Para Kkadan +5 more
wiley +1 more source
Esculetin Attenuates Inflammation and Fibrosis to Prevent AKI-to-CKD Transition in Adenine-Induced Renal Injury by Inhibiting the EGFR/SRC/PI3K/AKT/NF-κB Signaling Axis. [PDF]
Chen J +8 more
europepmc +1 more source
Investigations Into the Metabolism and Elimination of Tesofensine in Human Urine
This study investigated tesofensine metabolism and urinary elimination after a single 483 μg intake via a dietary supplement. In six volunteers, urine was collected up to 659 h. LC‐HRMS/MS identified four tentative metabolites; maximum urinary concentrations reached 4 ng/mL within 4–48 h.
O. Krug, A. Thomas, M. Thevis
wiley +1 more source
Molecular and Functional Interactions Between Cisplatin and Nicotinamide: A Combined Computational, Spectroscopic, and Biological Study. [PDF]
Szefler B +7 more
europepmc +1 more source

