Results 201 to 210 of about 47,793 (252)
Trypanosoma brucei adenine-phosphoribosyltransferases mediate adenine salvage and aminopurinol susceptibility but not adenine toxicity [PDF]
International Journal for Parasitology: Drugs and Drug Resistance, 2014 African trypanosomes, like all obligate parasitic protozoa, cannot synthesize purines de novo and import purines from their hosts to build nucleic acids. The purine salvage pathways of Trypanosoma brucei being redundant, none of the involved enzymes is likely to be essential.
Harry P de Koning +2 more
exaly +7 more sources
Adenine auxotrophy - be aware: some effects of adenine auxotrophy inSaccharomyces cerevisiaestrain W303-1A [PDF]
FEMS Yeast Research, 2014 Adenine auxotrophy is a commonly used genetic marker in haploid yeast strains. Strain W303-1A, which carries the ade2-1 mutation, is widely used in physiological and genetic research.
Agnese Kokina +2 more
exaly +3 more sources
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Studies of the binding of adenine to adenine phosphoribosyltransferase
Canadian Journal of Biochemistry, 1970The groups on adenine phosphoribosyltransferase and on adenine which are involved in the binding of this substrate were investigated by comparing the inhibition constant of adenine with those obtained for analogues of adenine, by determining the effect of pH on the Michaelis constant of adenine, and by protection by adenine against enzyme inactivation
R E, Gadd, J F, Henderson
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Vox Sanguinis, 1966
SummaryThe beneficial effect of adenine on red cells of blood stored in A.C.D. at 4°C, has been confirmed by post‐transfusion survival studies in rabbits and by biochemical studies of human and rabbit blood. Nevertheless probably this effect of adenine is too unreliable for routine use in the storage of blood for transfusion.In human red cells adenine ...
B A, Hurn, D N, Whitmore, S P, Lock
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SummaryThe beneficial effect of adenine on red cells of blood stored in A.C.D. at 4°C, has been confirmed by post‐transfusion survival studies in rabbits and by biochemical studies of human and rabbit blood. Nevertheless probably this effect of adenine is too unreliable for routine use in the storage of blood for transfusion.In human red cells adenine ...
B A, Hurn, D N, Whitmore, S P, Lock
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Transfusion, 1981
Four different media for erythrocyte preservation have been compared by studying 16 variables mainly describing the purine metabolism and glycolysis of the erythrocyte. The concentrations of the additives in the erythrocyte suspensions were as follows: adenine, 0.25 mmol/l; adenine, 0.75 mmol/l; adenine, 0.25 and inosine, 0.50 mmol/l; and adenine, 0.25
C H, de Verdier +4 more
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Four different media for erythrocyte preservation have been compared by studying 16 variables mainly describing the purine metabolism and glycolysis of the erythrocyte. The concentrations of the additives in the erythrocyte suspensions were as follows: adenine, 0.25 mmol/l; adenine, 0.75 mmol/l; adenine, 0.25 and inosine, 0.50 mmol/l; and adenine, 0.25
C H, de Verdier +4 more
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The adenine methylation debate
Science, 2022N 6 -methyl-2′-deoxyadenosine (6mA) is less prevalent in metazoan DNA than thought
Konstantinos, Boulias +1 more
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Vertical Ionization Energies of Adenine and 9-Methyl Adenine
The Journal of Physical Chemistry A, 2009Vertical ionization energies of 9-H adenine and 9-methyl adenine have been calculated with the following, ab initio, electron propagator methods: the outer valence Green's function (OVGF), partial third-order theory (P3), and the third-order algebraic diagrammatic construction, or ADC(3). Basis set effects have been systematically examined. All methods
O, Dolgounitcheva +2 more
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Mechanisms of inhibition of adenine phosphoribosyltransferase by adenine nucleosides and nucleotides
Canadian Journal of Biochemistry, 1970Kinetic studies of the inhibition of adenine phosphoribosyltransferase by adenine 6′-deoxyallofuranoside and 2′-deoxyadenylate indicate that both compounds bind to free enzyme and to the enzyme–phosphoribosylpyrophosphate complex, although they bind with different relative affinities to each enzyme form. The sites to which these inhibitors bind appear
J F, Henderson +3 more
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Adenine Consumption in Stored Citrate-Phosphate- Dextrose-Adenine Blood
Vox Sanguinis, 1980Abstract. Plasma adenine concentration was measured in five units of citrate‐phosphate‐dextrose‐adenine (0.25 mmol/1 adenine) whole blood during storage at +4°C. The adenine levels decreased to 50% in 9–10 days and to approximately 15% in 3 weeks. In spite of this rapid consumption of adenine, the adenosine triphosphate levels were well maintained ...
A, Kreuger, O, Akerblom
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Science, 1989
Oligomerization of HCN (1 molar) in the presence of added formaldehyde (0.5 molar) produced an order of magnitude more 8-hydroxymethyladenine than adenine or any other biologically significant purine. This result suggests that on the prebiotic Earth, nucleoside analogs may have been synthesized directly in more complex mixtures of HCN with other ...
A W, Schwartz, C G, Bakker
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Oligomerization of HCN (1 molar) in the presence of added formaldehyde (0.5 molar) produced an order of magnitude more 8-hydroxymethyladenine than adenine or any other biologically significant purine. This result suggests that on the prebiotic Earth, nucleoside analogs may have been synthesized directly in more complex mixtures of HCN with other ...
A W, Schwartz, C G, Bakker
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