Results 181 to 190 of about 397,718 (300)

Engineering Bisubstrates to Target m6Am RNA Methyltransferases: Synthesis and Computational Studies

Chemistry – A European Journal, EarlyView.
Use of the convertible nucleoside approach to synthesize m6Am RNA methyltransferase bisubstrates. This methodology allows for the introduction of modifications on the SAM analog moiety and the RNA substrate part, including the introduction of a cap analog by click chemistry.
Yoann Colas, Laurent Le Corre, Mélanie Ethève‐Quelquejeu, Emmanuelle Braud   +3 more
wiley   +1 more source

A High Fat/High Sucrose Diet Alters the Skeletal Response to Adenine-Induced Chronic Kidney Disease in Male Rats. [PDF]

Calcif Tissue Int
Metzger CE, Tak LY, LaPlant AN, Allen MR.   +3 more
europepmc   +1 more source

Carbon Dots for Cancer Theranostics: Synthesis Strategies, Luminescence Properties, and Advances in Bioimaging‐Guided Diagnosis and Therapy

Chemistry – A European Journal, EarlyView.
Lighting up the path to precision oncology: This review comprehensively summarizes the rational design of carbon dots (CDs), elucidating how core size, surface chemistry, and heteroatom doping dictate their luminescence mechanisms. Special emphasis is placed on engineering NIR‐II emissive CDs for deep‐tissue imaging.
Zekun Yan, Yupeng Liu, Jinyun Tan, Songnan Qu   +3 more
wiley   +1 more source

Simultaneous Detection and Quantification of Adenine Nucleotides in Mammalian Cultured Cells by HPLC. [PDF]

ACS Omega
Kopel B, Prado FM, Guimarães-Ramos SL, de Moura RD, Di Mascio P, Hoch NC, de Medeiros MHG, de Souza-Pinto NC.   +7 more
europepmc   +1 more source

C‐Terminal Nucleobase Modification Amplifies Peptide‐Mediated Liposome Fusion

Chemistry – A European Journal, EarlyView.
Let's come together right now. Cationic peptides are known to promote aggregation of negatively charged liposomes through electrostatic interaction. The process is reversible: once neutrality is achieved, liposomes disaggregate. Here, we demonstrate that end‐capping peptides with nucleobases turns the process into irreversible fusion.
Laura Morbiato, Giacomo Bettin, Chiara Dalla Torre, Lorenzo Stella, Marta De Zotti   +4 more
wiley   +1 more source

Functional analysis of <i>purM</i> in <i>Burkholderia cenocepacia</i> using a trimethoprim-selectable allelic exchange and mini-Tn7 complementation approach. [PDF]

Microbiol Spectr
Noe MM, Meesilpavikkai K, Ajimathorn Y, Sawatpanich A, Saninjuk K, Sermswan RW, Chirakul S.   +6 more
europepmc   +1 more source

Click Capture SELEX for the Identification of Click‐Modified Aptamers Targeting Small Molecules in Solution

Chemistry – A European Journal, EarlyView.
Using kanamycin A as a model target, we developed click‐capture SELEX to identify nucleobase‐modified aptamers capable of binding small molecules in solution. This approach enables flexible incorporation of nucleobase modifications via CuAAC, allowing the chemical properties of the aptamer to be tailored to the target molecule.
Philipp Menke, Carmelo Di Primo, Felix Bernhardt, Alea Schröder, Christian Renzl, Günter Mayer   +5 more
wiley   +1 more source

Dynamic Control of Nucleic Acids Self‐Assembly and Expression Using Photoswitches

Chemistry – A European Journal, EarlyView.
We review here the recent progress made in the design of molecular photoswitches, and highlight their implementation for the dynamic control over nucleic acids self‐assembly and expression. ABSTRACT Synthetic nucleic acids have become readily available and now constitute versatile building blocks in materials science—where they can be used to engineer ...
Noemí Nogal, Hugo Laigle, Maxime Mansy, Sébastien Ulrich, Mathieu Surin   +4 more
wiley   +1 more source

A Systematic Review on Disease‐Modifying Therapies in Parkinsonian Disorders

Clinical Pharmacology &Therapeutics, EarlyView.
Parkinsonian disorders, including Parkinson's disease, Lewy body dementia, multiple system atrophy, and progressive supranuclear palsy, are progressive neurodegenerative conditions with no treatment options to slow disease progression. This systematic review provides an overview of evidence of disease‐modifying therapies that have been evaluated in ...
Pepijn P.N.M. Eijsvogel, Lars M.G. Smits, Philip H.C. Kremer, Geert Jan Groeneveld   +3 more
wiley   +1 more source

Machine Learning–Enhanced Fluorescence Cryptography with NADH‐Responsive Polymer Dots

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
This study presents a smart anticounterfeiting system using semiconducting polymer dots (Pdots) that exhibit tunable fluorescence responses to NADH. By integrating these dynamic optical signals with machine learning–based decoding, the work establishes a secure and intelligent encryption platform, showing a novel strategy that links chemical sensing ...
Zhengkun Zhan, Mingyue Gong, Zirui Zeng, Hangyu Liu, Xiaoliang Li, Zhuxin Dong, Xiaoju Men, Haobin Chen   +7 more
wiley   +1 more source