Results 221 to 230 of about 487,247 (373)

Role of N ⁶-Adenine DNA Methylation in Alternative Splicing and Endosymbiosis in the Unicellular Eukaryote <i>Paramecium bursaria</i>

, 2022
Bo Pan, Fei Ye, Wei Fan, Alan Warren, Yuanyuan Wang, Shan Gao   +5 more
openalex   +1 more source

Structure‐Guided Engineering of a Promiscuous O‐Methyltransferase for a SAM Regeneration Biocatalysis Platform of Methylated Pharmaceuticals

Advanced Science, EarlyView.
A substrate promiscuous and regioselective O‐methyltransferase, SmOMT, is functionally and structurally characterized. A double mutant, SmOMTE152A/I306A, exhibited enhanced catalytic activity. By coupling this mutant with a mutant halide methyltransferase, AtHMTV140T, for SAM regeneration, a superior artificial fusion enzyme, AtHMTV140T‐L95‐SmOMTE152A ...
Xiran Xiong, Jun Song, Shihan Li, Lu Jin, Qi He, Baohui Zhang, Yan Cao, Shanyong Yi, Yanfang Yang, Xiang Li, Juan Li, Wei Huang   +11 more
wiley   +1 more source

<i>Lactiplantibacillus plantarum</i> HY7718 Attenuates Renal Injury in an Adenine-Induced Chronic Kidney Disease Mouse Model via Inhibition of Inflammation and Apoptosis. [PDF]

Int J Mol Sci
Kim H, Jeong JW, Jeong H, Lee D, Gwon H, Lee K, Kim JY, Shim JJ, Lee JH.   +8 more
europepmc   +1 more source

DNA methylation on N6-adenine in mammalian embryonic stem cells

Nature, 2016
Tao P. Wu, Tao Wang, M. Seetin, Yongquan Lai, Shijia Zhu, Kaixuan Lin, Yifei Liu, S. Byrum, S. Mackintosh, Mei Zhong, A. Tackett, Guilin Wang, Lawrence S. Hon, Gang Fang, J. Swenberg, A. Xiao   +15 more
semanticscholar   +1 more source

Synthesis of Bispecific Conjugates by ADP‐Ribosyl Cyclases

Advanced Science, EarlyView.
Genetic fusion of a CD38 enzymatic domain to antibody scaffolds allows site‐specific conjugation of small‐molecule ligands. Using this approach, a PSMA ligand DUPA is conjugated with an anti‐human CD3 Fab antibody. The resulting bispecific anti‐CD3‐DUPA conjugate facilitates recruitment and activation of cytotoxic T cells against PSMA‐expressing ...
Sunny H. Kim, Arshad J. Ansari, Lei Zhang, Guoyun Kao, Thuc Oanh Hoang, Zeyu Zhang, Srinivasarao Singireddi, Benjamin B. Katz, Yong Zhang   +8 more
wiley   +1 more source

PET imaging of mitochondrial complex-I in the adenine-induced tubulointerstitial nephropathy mouse model using [¹⁸F]BCPP-BF. [PDF]

EJNMMI Radiopharm Chem
Dahl K, Johnström P, Toth M, Sousa VC, Ericsson C, Strömstedt M, Inghardt T, Cortés González MA, Reznichenko A, Jucaite A, Cselényi Z, Unwin R, Ohba H, Halldin C, Challis B, Tsukada H, Schou M.   +16 more
europepmc   +1 more source

Studies of Nucleosides and Nucleotides. XLIII, Purine Cyclonucleosides.(10). Optical Rotatory Dispersion and Circular Dichroism of Adenine 8-Cyclonucleosides

, 1971
Morio Ikehara, Masakatsu Kaneko, Yuji Nakahara, Shoji Yamada, Seiichi Uesugi   +4 more
openalex   +2 more sources

Advanced Therapeutic Approach Based on LDHs–Mimetic Oxidoreductase

Advanced Science, EarlyView.
Overview of Sructure, Multienzyme‐mimicking Activity and Advanced Therapeutic Approach Based on LDHs–Mimetic Oxidoreductase. Abstract Redox dysregulation is recognized as a key driver in the pathophysiology of numerous refractory diseases, contributing significantly to the progression and poor prognosis.
Kai Song, Yu Wei, Peng Jia, Shan He, Qian Wang, Manman Xu, Hongzhi Liu, Pengtao Bao, Shanyue Guan, Xiaozhong Qu   +9 more
wiley   +1 more source

When the Stones Keep Hitting, Leave No Stone Unturned: A Report of Two Cases of Adenine Phosphoribosyltransferase (APRT) Deficiency Progressing to End-Stage Renal Failure and Recurrence Post-transplant in One of Them. [PDF]

Cureus
Chafekar N, Omosule B, Aldujaili M, Kamalanathan M.   +3 more
europepmc   +1 more source

Effect of adenine and related compounds on spore formation and thiostrepton production by purine auxotrophic mutants of Streptomyces azureus ATCC 14921.

, 1990
Seiya Ogata, Katumi Doi, Sadako Yamada
openalex   +2 more sources