Results 41 to 50 of about 417,743 (333)

Back-electron transfer suppresses the periodic length dependence of DNA-mediated charge transport across adenine tracts [PDF]

, 2008
DNA-mediated charge transport (CT) is exquisitely sensitive to the integrity of the bridging π-stack and is characterized by a shallow distance dependence. These properties are obscured by poor coupling between the donor/acceptor pair and the DNA bridge,
Augustyn, Katherine E., Barton, Jacqueline K., Davis, Molly L., Genereux, Joseph C., Shao, Fangwei   +4 more
core   +2 more sources

Quadracyclic Adenine: A Non‐Perturbing Fluorescent Adenine Analogue

Chemistry – A European Journal, 2012
AbstractFluorescent‐base analogues (FBAs) comprise a group of increasingly important molecules for the investigation of nucleic acid structure and dynamics as well as of interactions between nucleic acids and other molecules. Here, we report on the synthesis, detailed spectroscopic characterisation and base‐pairing properties of a new environment ...
Dierckx, Anke, Miannay, Francois-Alexandre, Ben Gaied, Nouha, Preus, Søren, Björck, Markus, Brown, Tom, Wilhelmsson, L. Marcus   +6 more
openaire   +3 more sources

(1RS,2RS,6RS)-2-(6-Amino-9H-purin-9-yl)-8-azaspiro[5.6]dodec-10-en-1-ol Dihydrochloride

Molbank, 2022
The title compound (1RS,2RS,6RS)-2-(6-Amino-9H-purin-9-yl)-8-azaspiro[5.6]dodec-10-en-1-ol dihydrochloride was synthesized for the first time in two steps, the first of which was a regioselectivity of epoxide ring-opening reaction under the action of ...
Ildar R. Iusupov, Konstantin A. Lyssenko, Andrea Altieri, Alexander V. Kurkin   +3 more
doaj   +1 more source

The Dissipative Photochemical Origin of Life: UVC Abiogenesis of Adenine

Entropy, 2021
The non-equilibrium thermodynamics and the photochemical reaction mechanisms are described which may have been involved in the dissipative structuring, proliferation and complexation of the fundamental molecules of life from simpler and more common ...
Karo Michaelian
doaj   +1 more source

Adenine deaminase and adenine utilization in Saccharomyces cerevisiae [PDF]

Journal of Bacteriology, 1992
Compared with other purine salvage and nitrogen catabolism enzymatic activities, adenine deaminase (adenine aminohydrolase [AAH]; EC 3.5.4.2) activity in Saccharomyces cerevisiae is uniquely regulated. AAH specific activity is not induced by adenine and is reduced sevenfold when cells are cultivated in medium containing proline in place of ammonium as ...
openaire   +2 more sources

Adenine decreases hypertrophic effects through interleukin-18 receptor

Chinese Journal of Physiology, 2019
Cardiac hypertrophy is the main cause of heart failure. Levels of circulating interleukin-18 (IL-18) have been reported to increase in congestive heart disease and cardiac hypertrophy. Relationships among IL-18 levels, IL-18 receptor (IL-18R) expression,
Yi-Feng Yang, Yao-Jen Liang
doaj   +1 more source

Mutations in valosin-containing protein (VCP) decrease ADP/ATP translocation across the mitochondrial membrane and impair energy metabolism in human neurons [PDF]

, 2017
Mutations in the gene encoding valosin-containing protein (VCP) lead to multisystem proteinopathies including frontotemporal dementia. We have previously shown that patient-derived VCP mutant fibroblasts exhibit lower mitochondrial membrane potential ...
Abramov, Andrey Y. Abramov, Angelova, Bartolome, Bobba, Brand, Brown, Charles Arber, Ding, Edri, Elisavet Preza, Eva Carro, Fernando Bartolome, Ganote, Henry Houlden, Imamura, Johnson, Kokoszka, Krauss, Ludtmann, Macarena de Vicente, Marthe H.R. Ludtmann, Meyer, Muqit, Nalbandian, Nalbandian, Nalbandian, Okita, Papkovskaia, Plun-Favreau, Schirris, Selina Wray, Shi, Shi, Sonia Gandhi, Sposito, Vallier, Vieira, Weihl, Weinbach, Weydt, Wray, Yin, Zhivotovsky   +43 more
core   +2 more sources

Infrared Spectral Signatures of Nucleobases in Interstellar Ices I: Purines

Life, 2023
The purine nucleobases adenine and guanine are complex organic molecules that are essential for life. Despite their ubiquitous presence on Earth, purines have yet to be detected in observations of astronomical environments.
Caroline Antunes Rosa, Alexandre Bergantini, Péter Herczku, Duncan V. Mifsud, Gergő Lakatos, Sándor T. S. Kovács, Béla Sulik, Zoltán Juhász, Sergio Ioppolo, Heidy M. Quitián-Lara, Nigel J. Mason, Claudia Lage   +11 more
doaj   +1 more source

RETRACTED: Adenine Combined with Cisplatin Promotes Anticancer Activity against Hepatocellular Cancer Cells through AMPK-Mediated p53/p21 and p38 MAPK Cascades

Pharmaceuticals, 2022
Cisplatin has been widely used in cancer treatments. Recent evidence indicates that adenine has potential anticancer activities against various types of cancers. However, the effects of the combination of adenine and cisplatin on hepatocellular carcinoma
Jhen-Yu Huang, You-Cian Lin, Han-Min Chen, Jiun-Tsai Lin, Shao-Hsuan Kao   +4 more
doaj   +1 more source

The Role of Organic Peroxides in the Induction of Mutations [PDF]

, 1949
The discovery by Wyss, Stone, and Clark' that bacteria grown on a substrate recently exposed to ultra-violet light are subject to high mutation rates shows clearly that some meta-stable chemical substance, probably of no great complexity, is an ...
Cleland, George H., Dickey, Frank H., Lotz, Carol   +2 more
core   +1 more source