Adenine base editor–mediated splicing remodeling activates noncanonical splice sites [PDF]
Journal of Biological Chemistry, 2023 Qing Li
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Engineering an adenine base editor in human embryonic stem cells with minimal DNA and RNA off-target activities [PDF]
Molecular Therapy - Nucleic Acids, 2022 Zhenwu Zhang +2 more
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Phage-assisted evolution of an adenine base editor with improved Cas domain compatibility and activity [PDF]
Nat Biotechnol, 2020 Michelle F. Richter +11 more
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Examination of the Cell Cycle Dependence of Cytosine and Adenine Base Editors
Frontiers in Genome Editing, 2022 Base editors (BEs) are genome editing agents that install point mutations with high efficiency and specificity. Due to their reliance on uracil and inosine DNA damage intermediates (rather than double-strand DNA breaks, or DSBs), it has been hypothesized that BEs rely on more ubiquitous DNA repair pathways than DSB-reliant genome editing methods, which
Cameron A. Burnett +5 more
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An adenine base editor with expanded targeting scope using SpCas9‐
Plant Biotechnol J, 2019 Katsuya Negishi +5 more
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Functional restoration of a CFTR splicing mutation through RNA delivery of CRISPR adenine base editor [PDF]
Molecular Therapy, 2023 Giulia Mäule, Anna Cereseto
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Ribose supplementation alone or with elevated creatine does not preserve high energy nucleotides or cardiac function in the failing mouse heart [PDF]
, 2013 Background: Reduced levels of creatine and total adenine nucleotides (sum of ATP, ADP and AMP) are hallmarks of chronic heart failure and restoring these pools is predicted to be beneficial by maintaining the diseased heart in a more favourable energy ...
Aksentijevic, Dunja +6 more
core +14 more sources
PhieABEs: a PAM‐less/free high‐efficiency adenine base editor toolbox with wide target scope in plants [PDF]
Plant Biotechnology Journal, 2022 Dongchang Zeng, Taoli Liu, Yang Xue
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Human cell based directed evolution of adenine base editors with improved efficiency [PDF]
Nature Communications, 2021 Abstract Adenine base editors (ABE) are genome-editing tools that have been harnessed to introduce precise A•T to G•C conversion. However, the low activity of ABE at certain sites remains a major bottleneck that precludes efficacious applications.
Junhao Fu +11 more
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Elimination of Cas9-dependent off-targeting of adenine base editor by using TALE to separately guide deaminase to target sites [PDF]
Cell Discov, 2022 Yang Liu +13 more
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