The Role of Adenine Nucleotide Translocase in the Mitochondrial Permeability Transition [PDF]
Cells, 2020 The mitochondrial permeability transition, a Ca2+-induced significant increase in permeability of the inner mitochondrial membrane, plays an important role in various pathologies.
Nickolay Brustovetsky
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CFAP45 deficiency causes situs abnormalities and asthenospermia by disrupting an axonemal adenine nucleotide homeostasis module [PDF]
Nature Communications, 2020 The mechanism by which adenosine monophosphate modulates dynein ATPase-mediated ciliary and flagellar beating remains obscure. Here the authors identify an axonemal module including cilia and flagella associated protein 45 that supports adenine ...
Gerard W. Dougherty +50 more
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Increased Adenine Nucleotide Degradation in Skeletal Muscle Atrophy. [PDF]
Int J Mol Sci, 2019 Adenine nucleotides (AdNs: ATP, ADP, AMP) are essential biological compounds that facilitate many necessary cellular processes by providing chemical energy, mediating intracellular signaling, and regulating protein metabolism and solubilization.
Miller SG, Hafen PS, Brault JJ.
europepmc +4 more sources
Regulation of Adenine Nucleotide Metabolism by Adenylate Kinase Isozymes: Physiological Roles and Diseases. [PDF]
Int J Mol Sci, 2023 Adenylate kinase (AK) regulates adenine nucleotide metabolism and catalyzes the ATP + AMP ⇌ 2ADP reaction in a wide range of organisms and bacteria.
Fujisawa K.
europepmc +2 more sources
Effect of guanidinoacetic acid on the growth performance, myofiber, and adenine nucleotide of meat-type rabbits [PDF]
Animal Bioscience, 2023 Objective This study aimed to investigate the effect of dietary guanidinoacetic acid (GAA) on the growth performance, slaughter traits, myofiber, and adenine nucleotide of meat-type rabbits.
Yuanxiao Li +3 more
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Adenine Nucleotide and Nicotinamide Adenine Dinucleotide Measurements in Plants [PDF]
Current Protocols in Plant Biology, 2020 AbstractAs the principal co‐factors of many metabolic pathways, the measurement of both adenine nucleotides and nicotinamide adenine dinucleotide provides important information about cellular energy metabolism. However, given their rapid and reversible conversion as well as their relatively low concentration ranges, it is difficult to measure these ...
Zhang, Youjun +4 more
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Nicotinamide Adenine Nucleotide—The Fountain of Youth to Prevent Oocyte Aging? [PDF]
Cells, 2021 According to the U.S. Special Operations Command (SOCOM), new clinical trials of an anti-aging oral treatment using nicotinamide adenine nucleotide are planned for 2022.
Paweł Kordowitzki +2 more
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Depletion of Toxoplasma adenine nucleotide translocator leads to defects in mitochondrial morphology [PDF]
Parasites & Vectors, 2022 Background Adenine nucleotide translocase (ANT) is a protein that catalyzes the exchange of ADP/ATP across the inner mitochondrial membrane. Beyond this, ANT is closely associated with cell death pathways and mitochondrial dysfunction.
Yihan Wu +5 more
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Ribose Supplementation Alone or with Elevated Creatine Does Not Preserve High Energy Nucleotides or Cardiac Function in the Failing Mouse Heart. [PDF]
PLoS ONE, 2013 BackgroundReduced levels of creatine and total adenine nucleotides (sum of ATP, ADP and AMP) are hallmarks of chronic heart failure and restoring these pools is predicted to be beneficial by maintaining the diseased heart in a more favourable energy ...
Kiterie M E Faller +6 more
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Interaction of Agaric Acid with the Adenine Nucleotide Translocase Induces Mitochondrial Oxidative Stress [PDF]
Biochemistry Research International, 2020 Mitochondrial permeability transition is characterized by the opening of a transmembranal pore that switches membrane permeability from specific to nonspecific.
Edmundo Chávez +5 more
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