Alu Overexpression Leads to an Increased Double‐Stranded RNA Signature in Dermatomyositis
Arthritis &Rheumatology, EarlyView.Objective Dermatomyositis is an autoimmune condition characterized by a high interferon signature of unknown etiology. Because coding sequences constitute <1.2% of our genomes, there is a need to explore the role of the noncoding genome in disease pathogenesis.
Rayan Najjar +2 more
wiley +1 more source
Frontiers in MicrobiologyA single nucleotide polymorphism (SNP) in the 126 bp untranslated region (UTR) directly upstream of Campylobacter jejuni’s cysM (cysteine synthase) results in significant effects on gene transcription.
Nereus W. Gunther IV +6 more
doaj +1 more source
Metal-ion binding and metal-ion induced folding of the adenine-sensing riboswitch aptamer domain [PDF]
, 2010 Divalent cations are important in the folding and stabilization of complex RNA structures. The adenine-sensing riboswitch controls the expression of mRNAs for proteins involved in purine metabolism by directly sensing intracellular adenine levels ...
Noeske, Jonas +2 more
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The Potential of Phytochemicals to Overcome Multidrug Resistance in Metastatic Melanoma
Chemistry &Biodiversity, EarlyView.ABSTRACT Metastatic melanoma is the most lethal form of skin cancer, accounting for most skin cancer‐related deaths. Immunotherapies and targeted therapies have improved overall and progression‐free survival rates in metastatic melanoma patients. The effectiveness of these therapies decreases due to multidrug resistance (MDR).
Jacqueline Maphutha +4 more
wiley +1 more source
Two-pore channel regulators - Who is in control?
Frontiers in PhysiologyTwo-pore channels (TPCs) are adenine nucleotide and phosphoinositide regulated cation channels. NAADP activates and ATP blocks TPCs, while the endolysosomal phosphoinositide PI(3,5)P2 activates TPCs.
Rebecca Deutsch +5 more
doaj +1 more source
Catalog of 434 single-nucleotide polymorphisms (SNPs) in genes of the alcohol dehydrogenase, glutathione S-transferase, and nicotinamide adenine dinucleotide, reduced (NADH) ubiquinone oxidoreductase families [PDF]
, 2001 Aritoshi Iida +9 more
openalex +1 more source
[Adenine nucleotides in migraine].
Neurologia (Barcelona, Spain), 1991 Several studies have shown that migraine is associated with an abnormal platelet activation state, characterized by increased plasma levels of platelet BTG and PF4 proteins. Adenine nucleotides are contained in platelets as a part of the dense granules released during platelet activation.
R, Leira +5 more
openaire +1 more source
Exploring RNA G‐Quadruplex Stability in the Gas Phase: Insights from Native Mass Spectrometry
ChemPlusChem, EarlyView.This study explores RNA G‐quadruplex structures using native mass spectrometry to better understand their stability during desolvation and in the gas phase. Although increasing net charge reduces quadruplex stability due to Coulombic repulsion, even highly charged quadruplex ions do not spontaneously dissociate. Notably, for quadruplexes with lower net
Anna Ploner +2 more
wiley +1 more source
Possible Participation of Adenine Nucleotide Translocase ANT1 in the Cytotoxic Action of Progestins, Glucocorticoids, and Diclofenac on Tumor Cells. [PDF]
Pharmaceutics, 2023 Ulchenko D +4 more
europepmc +1 more source
Metabolic changes during cardiac regeneration in the axolotl
Developmental Dynamics, EarlyView.Abstract Background The axolotl is a prominent model organism of heart regeneration due to its ability to anatomically and functionally repair the heart after an injury that mimics human myocardial infarction. In humans, such an injury leads to permanent scarring. Cardiac regeneration has been linked to metabolism and the oxygenation state, but so far,
Anita Dittrich +10 more
wiley +1 more source