Results 151 to 160 of about 370,851 (253)

Protective effects of extracellular vesicle‐like nanoparticles derived from Cannabis sativa adventitious roots against UVB‐induced damage in human keratinocytes

open access: yesInternational Journal of Cosmetic Science, EarlyView.
Cannabis sativa root‐derived extracellular vesicle‐like nanoparticles (CA‐NPs) were isolated from adventitious root cultures and subjected to physicochemical characterization. Upon UVB exposure, keratinocytes exhibited increased ROS generation, apoptosis and MAPK activation, leading to oxidative stress and skin damage.
Dong Ho Bak   +5 more
wiley   +1 more source

Mitochondrial Acyl-CoA, adenine nucleotide translocase activity and oxidative phosphorylation in myocardial ischaemia

open access: yes, 1981
The hypothesis that inhibition of mitochondrial adenine nucleotide translocase activity by accumulation of long chain acyl-CoA esters might be responsible for the depression in mitochondrial energy metabolism in myocardial ischaemia was reinvestigated ...
Kotze J.C.N., Van Niekerk I., Lochner A.
core  

Epigenetic and Metabolic Changes That Drive Trained Immunity in Response to Microbes and Vaccines

open access: yesImmunology, EarlyView.
This graphical abstract illustrates how microbial products, vaccines and microbial metabolites activate pattern‐recognition receptor signalling, inducing metabolic rewiring and epigenetic remodelling. These changes establish long‐lasting trained immunity through the functional reprogramming of haematopoietic progenitors and innate immune cells, thereby
Desalegn Abebaw   +10 more
wiley   +1 more source

Expression of corticoid‐regulatory genes in the gills of Atlantic salmon (Salmo salar) parr and smolt and during salinity acclimation

open access: yesJournal of Fish Biology, EarlyView.
Abstract In teleost fishes, cortisol is the major corticoid and has both glucocorticoid and mineralocorticoid actions. However, how fish tissues discriminate between these distinct corticosteroid actions is unclear. In mammals, the major factors responsible for intracellular corticosteroid regulation are glucocorticoid receptors (grs) and the ...
Makoto Kusakabe   +4 more
wiley   +1 more source

Genomic variation drives plant flavor diversification

open access: yesJournal of Integrative Plant Biology, EarlyView.
This review explains how genomic variation shapes plant flavor by altering the biosynthetic and regulatory pathways of key attributes like sweetness, acidity, bitterness, piquancy, astringency, and aroma. It also discusses how multi‐omics, AI‐assisted breeding, and gene editing can translate this knowledge into plants with improved flavor, nutrition ...
Huimin Hu   +5 more
wiley   +1 more source

Plant cis‐regulatory grammar: Decoding the multidimensional code of transcriptional regulation for programmable crop engineering

open access: yesJournal of Integrative Plant Biology, EarlyView.
This review decodes the grammar of plant cis‐regulatory elements, revealing that their function emerges from sequence, chromatin accessibility, 3D topology, and cell type context. It highlights how single‐cell omics, CRISPR dissection, and AI‐driven design converge to enable predictive engineering and crop improvement. ABSTRACT Cis‐regulatory elements (
Libin Zhang, Maoteng Li
wiley   +1 more source

A NAC–MYB–cysteine regulatory module enhances drought and salt tolerance in soybean

open access: yesJournal of Integrative Plant Biology, EarlyView.
In the GmNAC3—GmMYB60—GmCYS20 module, GmNAC3 represses the transcription factor gene GmMYB60 and GmMYB60 suppresses the cysteine biosynthetic gene GmCYS20. GmCYS20‐mediated cysteine metabolism feeds back to limit GmMYB60 activity. This transcription—metabolism circuit enhances stress tolerance and offers breeding targets for resilient soybean ...
Nannan Zhang   +15 more
wiley   +1 more source

Genome‐scale insights into metabolic streamlining and photosynthetic energy balance in the extremophile green alga Picocystis salinarum (Picocystophyceae, Chlorophyta)

open access: yesJournal of Phycology, EarlyView.
Abstract Picocystis salinarum is an early‐diverging chlorophyte and the sole described member of the Picocystophyceae, frequently dominating hypersaline and alkaline lakes despite extreme physicochemical constraints. To elucidate the genomic foundations of its ecological success, we generated a fully annotated, chromosome‐scale nuclear genome assembly ...
Claude Lemieux   +2 more
wiley   +1 more source

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