Results 181 to 190 of about 370,851 (253)

Recent Advances in Reversed‐Phase Liquid Chromatography for Therapeutic Oligonucleotide and Conjugate Characterization: From Ion‐Pairing to Green Analytical Approaches

Analytical Science Advances, Volume 7, Issue 2, December 2026.
ABSTRACT Therapeutic oligonucleotides (ONs) have rapidly emerged as a novel class of treatments in the pharmaceutical industry, with over 25 medicines approved in the past decade. Ion‐pair reversed‐phase liquid chromatography coupled with mass spectrometry (IP‐RPLC‐MS) is widely used method for ON characterization.
Quang‐Dong Bui, Weronika Hewelt‐Belka, Tiny Deschrijver, Martin Gilar, Sebastiaan Eeltink   +4 more
wiley   +1 more source

POTENTIATION OF ADENOSINE AND THE ADENINE NUCLEOTIDES BY DIPYRIDAMOLE [PDF]

British Journal of Pharmacology and Chemotherapy, 1966
openaire   +2 more sources

The Boron–Neuron Connection: The Potential of Boron‐Containing Molecules for Treating Incurable Amyotrophic Lateral Sclerosis

ChemMedChem, Volume 21, Issue 21, 12 November 2026.
Can a single element help address the multifactorial nature of ALS? Boron‐containing compounds combine responsiveness to reactive oxygen species (ROS), neuroprotective activity, and favorable pharmacological properties, offering a distinctive framework for disease modification in a complex disease like ALS.
Nitesh Sanghai, Billy Vuong, Muhammad Shaharyar K. Afridi, Sasha Leggett, Hemin Roghzai, Geoffrey K. Tranmer   +5 more
wiley   +1 more source

The PIEZO1/CISD1/IP3R Mechanotransduction Axis Drives Macrophage Mitochondrial Dysfunction and Inflammatory Activation in Pulmonary Fibrosis

MedComm, Volume 7, Issue 11, November 2026.
In the pulmonary fibrotic microenvironment, mechanical signals activate PIEZO1 to mediate Ca2+ entry into macrophages. Increased CISD1/IP3R activity promotes Ca2+ transfer from the endoplasmic reticulum to mitochondria, leading to mitochondrial Ca2+ overload and opening of the mitochondrial permeability transition pore (MPTP). Consequently, macrophages
Yungeng Wei, Chao Xie, Xiangsheng Yang, Xiao Xiao Tang   +3 more
wiley   +1 more source

RNA degradomics and proteomics reveal the mechanism of dsProsβ1‐mediated proteasome targeting in Psylliodes chrysocephala

Pest Management Science, Volume 82, Issue 11, Page 10604-10614, November 2026.
RNA degradomics revealed dsProsβ1‐derived siRNA‐mediated mRNA cleavage events, mainly at uracil‐guanine and adenine‐adenine pairs. Proteasome inhibition via dsProsβ1 increased mitochondrial and cytoskeletal proteins while reducing translation‐related and mRNA‐binding proteins.
Doga Cedden, Gözde Güney, Michael Rostás, Stefan Scholten   +3 more
wiley   +1 more source

Turning up the heat: Can thermal therapy really protect muscle health in older adults?

Experimental Physiology, EarlyView.
Franck Brocherie, Yohan Rousse, Grégoire P. Millet   +2 more
wiley   +1 more source

Combating Campylobacter Resistance in Moroccan Poultry Using Essential Oil–Ciprofloxacin Combination

Veterinary Medicine and Science, Volume 12, Issue 6, November 2026.
With an estimated prevalence of 15.52% in Moroccan poultry, Campylobacter species pose a significant food safety concern. We investigated whether essential oils (EOs) could restore the efficacy of ciprofloxacin against multidrug‐resistant (MDR) strains.
Zineb Soubai, Nadia Ziyate, Rim Rais, Hamza Elhrech, Oumayma Aguerd, Abdelhakim Bouyahya, Taoufiq Benali, Mohamed Akhazzane, Hiba Mahir, Siham Fellahi, Waleed Al Abdulmonem, Imane El Houssni, Benaissa Attarassi, Nabila Auajjar   +13 more
wiley   +1 more source

Legacy of Recurrent Gene Flow and Evidence of Independent Evolution of ALS Resistance Mutations in Weedy Rice

Evolutionary Applications, Volume 19, Issue 11, November 2026.
ABSTRACT Weedy rice (Oryza spp.) provides a unique model for studying adaptive evolution because herbicide resistance can arise through both crop‐to‐weed gene flow and independent mutational events. In Brazil, nearly two decades of cultivation of imidazolinone (IMI)‐resistant rice have imposed intense selection for acetolactate synthase (ALS ...
Guilherme Menegol Turra, Paula Sinigaglia Angonese, Eduardo Carlos Rudell, Vinícius Ferrari Tasca, Catarine Markus, Aldo Merotto Junior   +5 more
wiley   +1 more source

Metabolic Profiling of Circulating and Tumour‐Infiltrating T Cells Uncovers Bioenergetic Checkpoints Linked With Immune and Clinical Skewing in Melanoma Patients

Immunology, Volume 179, Issue 3, Page 486-515, November 2026.
In this study, we revealed the disturbed metabolic status of circulating and tumour‐infiltrating CD4+ and CD8+ T cells in melanoma patients through targeted metabolomic and lipidomic (on sorted subsets) and at single cell level using the SCENITH method.
Hugo Brouque, Kareem Mahdy, Stephane Mouret, Sylvain Henry, Camille Niveau, Mélanie Cettour‐Cave, Martin Pelosse, Florence de Fraipont, Julie Charles, Andrei Turtoi, Philippe Saas, Caroline Aspord   +11 more
wiley   +1 more source

MdPHYB2‐MdPIF1 Module Regulates Transcription Factors to Mediate Light‐Dependent ALA‐Induced Apple Anthocyanin Biosynthesis

Plant, Cell &Environment, Volume 49, Issue 11, Page 7808-7824, November 2026.
ABSTRACT Light is a primary environmental signal that induces plant anthocyanin accumulation. The plant growth regulator 5‐aminolevulinic acid (ALA) has also been proven to effectively promote anthocyanin accumulation in apple. However, the underlying regulatory mechanisms remain unknown.
Liuzi Zhang, Yuyan An, Jianting Zhang, Liangju Wang   +3 more
wiley   +1 more source