Results 31 to 40 of about 772,486 (361)
Balkan Medical Journal, 2017 Background: Atopic dermatitis is the most common chronic inflammatory skin disease. A complex interaction of both genetic and environmental factors is thought to contribute to the disease. Aims: To evaluate whether single nucleotide polymorphisms in the
Ceren Can +5 more
doaj +1 more source
Deconvoluting AMP-activated protein kinase (AMPK) adenine nucleotide binding and sensing
Journal of Biological Chemistry, 2017 AMP-activated protein kinase (AMPK) is a central cellular energy sensor that adapts metabolism and growth to the energy state of the cell. AMPK senses the ratio of adenine nucleotides (adenylate energy charge) by competitive binding of AMP, ADP, and ATP ...
X. Gu +13 more
semanticscholar +1 more source
Structure and stereochemistry of the base excision repair glycosylase MutY reveal a mechanism similar to retaining glycosidases. [PDF]
, 2015 MutY adenine glycosylases prevent DNA mutations by excising adenine from promutagenic 8-oxo-7,8-dihydroguanine (OG):A mismatches. Here, we describe structural features of the MutY active site bound to an azaribose transition state analog which indicate a
Cao, Sheng +6 more
core +2 more sources
Human adenine nucleotide translocases physically and functionally interact with respirasomes
Molecular Biology of the Cell, 2017 A network of interactions for human adenine nucleotide translocases, required for oxidative phosphorylation, is reported. Of particular interest is an evolutionarily conserved and functionally important association with respiratory supercomplexes, which ...
Ya-Wen Lu +7 more
semanticscholar +1 more source
Conformationally Restricted Adenine Nucleotide Analogs in Mitochondrial Adenine Nucleotide Transport
Zeitschrift für Naturforschung C, 1978 Abstract The conformationally restricted adenine nucleotide analogs 8,3′anhydro-8-oxy-9-(β-ᴅ-xylofurano-syl) adenine-5′-O-tri (di) -phosphate (I) , and 8,2′-anhydro-8-oxy-9-(β-ᴅ-arabinofuranosyl) adenine-5′-O-tri (di)-phosphate (II), were prepared chemically as their α-32P-labelled compounds and compared with syn-structured 8-bromo AT(D)
K S, Boos, E, Schlimme, M, Ikehara
openaire +2 more sources
Biochemistry, 2014 Proteomics techniques have revealed that lysine acetylation is abundant in mitochondrial proteins. This study was undertaken (1) to determine the relationship between mitochondrial protein acetylation and insulin sensitivity in human skeletal muscle ...
Clinton J. Mielke +10 more
semanticscholar +1 more source
Nucleotide specificity of the enzymatic and motile activities of dynein, kinesin, and heavy meromyosin. [PDF]
, 1991 The substrate specificities of dynein, kinesin, and myosin substrate turnover activity and cytoskeletal filament-driven translocation were examined using 15 ATP analogues.
Furusawa, K +6 more
core +2 more sources
Cytosine, but not adenine, base editors induce genome-wide off-target mutations in rice
Science, 2019 Spotting off-targets from gene editing Unintended genomic modifications limit the potential therapeutic use of gene-editing tools. Available methods to find off-targets generally do not work in vivo or detect single-nucleotide changes.
Shuai Jin +10 more
semanticscholar +1 more source
Nucleotides: Structure and Properties [PDF]
, 2005 Nucleotides consist of a nitrogen-containing base, a five-carbon sugar, and one or more phosphate groups. Cells contain many types of nucleotides, which play a central role in a wide variety of cellular processes, including metabolic regulation and the ...
Bowater, RP
core +1 more source
Improving cytidine and adenine base editors by expression optimization and ancestral reconstruction
Nature Biotechnology, 2018 Base editors enable targeted single-nucleotide conversions in genomic DNA. Here we show that expression levels are a bottleneck in base-editing efficiency.
Luke W. Koblan +8 more
semanticscholar +1 more source