Results 111 to 120 of about 123,381 (324)
Annals of Neurology, EarlyView.Objective Amyotrophic lateral sclerosis (ALS) has a very specific neuroimaging signature, but the molecular underpinnings of the strikingly selective anatomic involvement have not elucidated to date. Accordingly, a large neuroimaging study was conducted with 258 participants to evaluate associations between patterns of neurodegeneration and focal ...
Marlene Tahedl +10 more
wiley +1 more source
HIGH PRESSURE EFFECTS ON ENDOGENOUS ADENINE NUCLEOTIDE LEVELS IN SEA URCHIN EGGS PRIOR TO FIRST CLEAVAGE [PDF]
, 1966 J. V. Landau
openalex +1 more source
Adenine Nucleotide Metabolites in Uremic Erythrocytes as Metabolic Markers of Chronic Kidney Disease in Children [PDF]
, 2021 Joanna Piechowicz +3 more
openalex +1 more source
Antagonism of Morphine Analgesia by Adenine, Adenosine, and Adenine Nucleotides
Experimental Biology and Medicine, 1973 SummaryAntagonism of the antinociceptive action of morphine in mice by prior parenteral administration of cAMP has been confirmed using two additional analgesic testing procedures, the hot-plate test and the stretching test. The analgesia-antagonistic property, however, is not specific for cAMP because it also occurred after pretreatment with compounds
D R, Gourley, S K, Beckner
openaire +2 more sources
Phase Separation of Nucleic Acids: Mechanisms, Properties, and Applications
Angewandte Chemie International Edition, EarlyView.Recent discoveries have shown that single‐stranded long‐chain nucleic acids can undergo temperature‐induced phase separation, enabling formation of micrometer‐sized condensates. This Minireview discusses the current mechanistic understanding of this phenomenon, highlights strategies for controlling the physical and chemical properties of these ...
Weixiang Chen +2 more
wiley +1 more source
Scientific Argumentation as a Foundation for the Design of Inquiry-Based Science Instruction [PDF]
, 2013 Despite the attention that inquiry has received in science education research and policy, a coherent means for implementing inquiry in the classroom has been missing [1].
Brodsky, L., Falk, A.
core +1 more source
BMEMat, EarlyView.Ultrasound‐responsive nanoplatforms reprogram the tumor immune microenvironment by targeting tumor cells, immune cells, and non‐immune stromal cells to enhance the efficacy of cancer immunotherapy. Abstract Cancer immunotherapy represents a significant advancement in cancer treatment by enhancing the specific recognition and elimination of cancer cells.
Shilong Zhao +4 more
wiley +1 more source
Energy Metabolism of Rickettsia typhi : Pools of Adenine Nucleotides and Energy Charge in the Presence and Absence of Glutamate [PDF]
, 1978 Jim C. Williams, Emilio Weiss
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Chemistry – A European Journal, EarlyView.Here we report a synthesis of the dinucleotide 4 for a projected future total synthesis of the m7G cap 1. Highlights of the route include: 1) a 3ʹ‐H‐phosphonate/5ʹ‐selenocyanate Michaelis‐Arbuzov coupling to forge the 3ʹ,5ʹ‐phosphoroselenolate; 2) an Amosova reductive selenomethylation to install the 2ʹ‐SeMe; 3) a solid CPR II 5ʹ‐O‐phosphitylation; and
K. Lawrence E. Hale +2 more
wiley +1 more source
Nature CommunicationsThe ryanodine receptor (RyR) is a critical drug target, yet dantrolene (DAN) remains the only FDA-approved inhibitor, limited by hepatotoxicity and unsuitable for chronic use.
Hadiatullah Hadiatullah +15 more
doaj +1 more source