Results 131 to 140 of about 63,943 (301)

Inhibition of protein synthesis induced by adenine nucleotides requires their metabolism into adenosine.

, 1995
Adenine nucleotides and adenosine inhibit the incorporation of radiolabelled leucine into proteins of isolated hepatocytes. Impairment occurred with nucleotides which can be converted into 9-beta-D-ribofuranosyladenine (adenosine) but was not observed ...
Tinton, S, Buc Calderon, Pedro
core   +1 more source

Mass Spectrometry Insights Into Post‐Translational Modifications in Extracellular Vesicles

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are membrane‐enclosed structures secreted by virtually all living cells, serving as essential mediators of intercellular communication in both physiological and pathological processes. There is growing interest in their potential applications as biomarkers, therapeutic targets, and drug delivery systems, which ...
Dávid Virág, Krisztián Márk Karvaly, Alexandra Molnár, Mirjam Balbisi, Júlia Németh, Lilla Turiák   +5 more
wiley   +1 more source

Characterization of the N⁶-etheno-bridge method to assess extracellular metabolism of adenine nucleotides: detection of a possible role for purine nucleoside phosphorylase in adenosine metabolism. [PDF]

Purinergic Signal, 2020
Jackson EK, Gillespie DG, Cheng D, Mi Z, Menshikova EV.   +4 more
europepmc   +1 more source

Biosynthesis of adenine nucleotides in Hevea brasiliensis latex

, 1997
Two keys enzymes in adenine nucleotides synthesis are located in the cytosol of #hevea# latex. The demonstration of their functioning in a paraphysiological medium and their biochimical characteristics make it possible to better understand their ...
Clément, Anne, Prévôt, Jean-Claude, Jacob, Jean-Louis, Gallois, Richard   +3 more
core  

Potent agonist action of 2-thioether derivatives of adenine nucleotides at adenylyl cyclase-linked P2y-purinoceptors

, 1995
1. Analogues of adenine nucleotides inhibited beta-adrenoceptor-stimulated cyclic AMP accumulation in C6 rat glioma cells with a pharmacological selectivity consistent with that for involvement of a P2Y-purinoceptor. 2.
Jacobson, Kenneth A., John W. O'Tuel, T. Kendall Harden, José L. Boyer, Fischer, Bilha, Kenneth A. Jacobson, Boyer, José L., O'Tuel, John W., Harden, T. Kendall, Bilha Fischer   +9 more
core   +1 more source

Metabolic and Volumetric Alterations in the Basal Ganglia and the Cerebellum in Dopa‐Responsive Dystonia in Symptomatic and Asymptomatic GCH1 Mutation Carriers

Movement Disorders, EarlyView.
ABSTRACT Background Dopa‐responsive dystonia is caused by pathogenic variants in the GCH1 gene. Although its clinical features and reduced penetrance are known, in vivo metabolic and structural alterations in symptomatic (sMC) and asymptomatic mutation carriers (aMC) remain poorly understood.
Jannik Prasuhn, Leon van Well, Marta M. Pokotylo, Feline Hamami, Joke‐Lina Aßmann, Katja Lohmann, Maximilian G. Ködderitzsch‐Mertins, Julia Henkel, Jan Uter, Alexander Münchau, Christine Klein, Anne Weissbach, Norbert Brüggemann   +12 more
wiley   +1 more source

Plasma Concentration of Irisin and Brain-Derived-Neurotrophic Factor and Their Association With the Level of Erythrocyte Adenine Nucleotides in Response to Long-Term Endurance Training at Rest and After a Single Bout of Exercise. [PDF]

Front Physiol, 2020
Rodziewicz E, Król-Zielińska M, Zieliński J, Kusy K, Ziemann E.   +4 more
europepmc   +1 more source

Review of Congenital Myasthenic Syndrome Caused by Pathogenic Variants in GFPT1

Muscle &Nerve, EarlyView.
ABSTRACT Glutamine:fructose‐6‐phosphate transaminase 1 (GFPT1) catalyzes the first and rate‐limiting step of the hexosamine biosynthetic pathway (HBP) to generate UDP‐GlcNAc. GFPT1 exon 9 is specifically spliced in in striated muscles, which makes a long isoform of GFPT1 (GFPT1‐L).
Kinji Ohno, Mohammad Nazim, Ruchen Zhang, Paniz Farshadyeganeh, Mikako Ito, Bisei Ohkawara   +5 more
wiley   +1 more source

Synthesis and Preliminary Evaluation of an ASGPr-Targeted Polycationic β-Cyclodextrin Carrier for Nucleosides and Nucleotides

Pharmaceutics
Most antiviral and anticancer nucleosides are prodrugs that require stepwise phosphorylation to their triphosphate nucleotide form for biological activity.
Jang-Ha Ryu, Weizhong Zheng, Xiao-Hong Yang, Hassan Elsaidi, Jim Diakur, Leonard I. Wiebe   +5 more
doaj   +1 more source

Adenosine hypodiphosphate ester, an analogue of ADP: analysis of the adenine–hypodiphosphate interaction mode in hypodiphosphate nucleotides and adenine salts

, 2018
Adenosine diphosphate (ADP) plays a crucial role in cell biochemistry, especially in metabolic pathways and energy storage. ADP itself, as well as many of its analogues, such as adenosine hypodiphosphate (AhDP), has been studied extensively, in ...
Marta Otręba, Katarzyna A. Ślepokura, Daria Budzikur, Łukasz Górecki   +3 more
core   +1 more source