Results 141 to 150 of about 114,992 (358)

Histochemical indications for a chemically complex signal produced by the cervical gill slit gland of the pygmy sperm whale (Kogia breviceps)

The Anatomical Record, EarlyView.
Abstract The pygmy sperm whale (Kogia breviceps) possesses an exocrine gland associated with its false gill slit pigmentation pattern. The cervical gill slit gland is a compound tubuloalveolar gland that produces a holocrine secretion and displays maturational changes in size and secretory histology. While the morphology of the cervical gill slit gland
Tiffany F. Keenan, William A. McLellan, Sentiel A. Rommel, Alexander M. Costidis, Craig A. Harms, J. G. M. Thewissen, Susan J. Rehorek, David S. Rotstein, Mark D. Gay, Alison R. Taylor, Heather N. Koopman, Ying Wang, Stephanie Kamel, D. Ann Pabst   +13 more
wiley   +1 more source

Metformin Improves Mitochondrial Respiratory Activity through Activation of AMPK

Cell Reports, 2019
Summary: Impaired mitochondrial respiratory activity contributes to the development of insulin resistance in type 2 diabetes. Metformin, a first-line antidiabetic drug, functions mainly by improving patients’ hyperglycemia and insulin resistance. However,
Yu Wang, Hongying An, Ting Liu, Caolitao Qin, Hiromi Sesaki, Shaodong Guo, Sally Radovick, Mehboob Hussain, Akhil Maheshwari, Fredric E. Wondisford, Brian O’Rourke, Ling He   +11 more
doaj  

Dynamical Transition and Heterogeneous Hydration Dynamics in RNA [PDF]

J. Phys. Chem. B. (2014) vol. 118, 7910-7919, 2014
Enhanced dynamical fluctuations of RNAs, facilitated by a network of water molecules with strong interactions with RNA, are suspected to be critical in their ability to respond to a variety of cellular signals. Using atomically detailed molecular dynamics simulations at various temperatures of purine (adenine)- and preQ$_1$ sensing riboswitch aptamers,
arxiv  

Solanidine‐derived CYP2D6 phenotyping elucidates phenoconversion in multimedicated geriatric patients

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Phenoconversion, a genotype‐phenotype mismatch, challenges a successful implementation of personalized medicine. The aim of this study was to detect and determine phenoconversion using the solanidine metabolites 3,4‐seco‐solanidine‐3,4‐dioic acid (SSDA) and 4‐OH‐solanidine as diet‐derived cytochrome P450 2D6 (CYP2D6) biomarkers in a ...
Jens Andreas Sarömba, Julian Peter Müller, Jolanta Tupiec, Anjali Roeth, Berkan Kurt, Florian Kahles, Thea Laurentius, Cornelius Bollheimer, Julia C. Stingl, Katja S. Just   +9 more
wiley   +1 more source

A van der Waals density functional study of adenine on graphite: Single molecular adsorption and overlayer binding [PDF]

arXiv, 2010
The adsorption of an adenine molecule on graphene is studied using a first-principles van der Waals functional (vdW-DF) [Dion et al., Phys. Rev. Lett. 92, 246401 (2004)]. The cohesive energy of an ordered adenine overlayer is also estimated. For the adsorption of a single molecule, we determine the optimal binding configuration and adsorption energy by
arxiv  

Adenine Abundance in a Collapsing Molecular Cloud [PDF]

arXiv, 2000
A vital ingredient of DNA molecule named adenine may be produced by successive addition of HCN during molecular cloud collapse and star formation. We compute its abundance in a collapsing cloud as a function of the reaction rate and show that in much of the circumstances the resulting amount may be sufficient to contaminate planets, comets and ...
arxiv  

Cucurbit[7]uril‐Styryl Dye Complexes for Fluorescent Recognition of DNA and Cell Imaging

ChemBioChem, EarlyView.
Recognition properties in solution and in cancer cells: a two dicationic cyanine dyes with different functionalities were developed and studied for their fluorescent properties, cytotoxicity and cellular imaging. The effect of encapsulation was checked using synthetic molecular container of cucurbit[7]uril.
Ekaterina Y. Chernikova, Maria A. Ustimova, Yuri V. Fedorov, Polina A. Chernikova, Ivan A. Godovikov, Nelly S. Chmelyuk, Maxim A. Abakumov, Olga A. Fedorova   +7 more
wiley   +1 more source

Adenine nucleotide metabolism in human blood platelets: a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Clinical Biochemistry at Massey University [PDF]

, 1985
At present, a skeletal muscle biopsy provides the most specific test for susceptibility to Malignant Hyperthermia (MH). This procedure is unsuitable for large scale screening of individuals and a simpler, less invasive test to distinguish MR-susceptible (
Farndale, Bruce Mathew
core  

Direct Base-to-Base Transitions in ssDNA Revealed by Tip-Enhanced Raman Scattering [PDF]

arXiv, 2016
In the present contribution, specifically designed single-stranded DNA (ssDNA) sequences composed of adenine and cytosine were used as nanometric rulers to target the maximum achievable spatial resolution of tip-enhanced Raman spectroscopy (TERS) under ambient conditions.
arxiv  

Purine Chemistry in the Early RNA World at the Origins of Life: From RNA and Nucleobases Lesions to Current Key Metabolic Routes

ChemBioChem, EarlyView.
In the nascent processes of the beginnings and evolution of life, nucleobases and especially purines, ribonucleos(t)ides and primitive RNAs have been continuously modified. A RNA‐peptide world and key metabolic pathways probably have emerged from the corresponding chemical modifications resulting from adenine deamination, purine alkylation and ...
Jean‐Luc Décout, Marie‐Christine Maurel   +1 more
wiley   +1 more source