Results 11 to 20 of about 118,017 (284)

A liquid chromatography-tandem mass spectrometry based method for the quantification of adenosine nucleotides and NAD precursors and products in various biological samples

open access: yesFrontiers in Immunology, 2023
Adenine nucleotides (AN) are ubiquitous metabolites that regulate cellular energy metabolism and modulate cell communication and inflammation. To understand how disturbances in AN balance arise and affect cellular function, robust quantification ...
Johanna Hiefner   +5 more
doaj   +1 more source

Insight into an Oxidative DNA-Cleaving DNAzyme: Multiple Cofactors, the Catalytic Core Map and a Highly Efficient Variant

open access: yesiScience, 2020
Summary: An oxidative DNA-cleaving DNAzyme (PL) employs a double-cofactor model “X/Cu2+” for catalysis. Herein, we verified that reduced nicotinamide adenine dinucleotide (NADH), flavin mononucleotide, cysteine, dithiothreitol, catechol, resorcinol ...
Wenqian Yu   +9 more
doaj   +1 more source

Substrate binding in the mitochondrial ADP/ATP carrier is a step-wise process guiding the structural changes in the transport cycle

open access: yesNature Communications, 2022
The mitochondrial ADP/ATP carrier transports adenine nucleotides. Here, authors identify the residues involved in substrate binding. One set forms the central substrate binding site and two asparagine/arginine pairs help to guide the substrates during ...
Vasiliki Mavridou   +5 more
doaj   +1 more source

Interplay of 'induced fit' and preorganization in the ligand induced folding of the aptamer domain of the guanine binding riboswitch [PDF]

open access: yes, 2006
Riboswitches are highly structured elements in the 50-untranslated regions (50-UTRs) of messenger RNA that control gene expression by specifically binding to small metabolite molecules. They consist of an aptamer domain responsible for ligand binding and
Noeske, Jonas   +5 more
core   +1 more source

Adenine Nucleotide and Nicotinamide Adenine Dinucleotide Measurements in Plants [PDF]

open access: yesCurrent Protocols in Plant Biology, 2020
AbstractAs the principal co‐factors of many metabolic pathways, the measurement of both adenine nucleotides and nicotinamide adenine dinucleotide provides important information about cellular energy metabolism. However, given their rapid and reversible conversion as well as their relatively low concentration ranges, it is difficult to measure these ...
Zhang, Youjun   +4 more
openaire   +4 more sources

The evolution of purinergic receptors involved in recognition of a blood meal by hematophagous insects

open access: yesMemorias do Instituto Oswaldo Cruz, 1987
Many blood feeders use adenine nucleotides as cues for locating blood meal. Structure-activity relationship of adenine nucleotides as phagostimulants varies between closely-related species of blood feeders. It is suggested that a preexisting diverse pool
Rachel Galun
doaj   +1 more source

Development and application of LC/HRPS for quantification of adenine nucleotides, creatine phosphate, and creatine in sturgeon spermatozoa

open access: yesCzech Journal of Animal Science, 2017
The objective of this study was to investigate the applicability of liquid chromatography coupled with high resolution product scan (LC/HRPS) mass spectrometry for simultaneous quantification of adenine nucleotides, creatine phosphate, and creatine ...
Pavlo Fedorov   +5 more
doaj   +1 more source

Interaction of low-energy electrons with the purine bases, nucleosides, and nucleotides of DNA [PDF]

open access: yes, 2006
The authors report results from computational studies of the interaction of low-energy electrons with the purine bases of DNA, adenine and guanine, as well as with the associated nucleosides, deoxyadenosine and deoxyguanosine, and the nucleotide ...
McKoy, Vincent, Winstead, Carl
core   +1 more source

DGR mutagenic transposition occurs via hypermutagenic reverse transcription primed by nicked template RNA. [PDF]

open access: yes, 2017
Diversity-generating retroelements (DGRs) are molecular evolution machines that facilitate microbial adaptation to environmental changes. Hypervariation occurs via a mutagenic retrotransposition process from a template repeat (TR) to a variable repeat ...
Guo, Huatao   +6 more
core   +3 more sources

H+ transport is an integral function of the mitochondrial ADP/ATP carrier. [PDF]

open access: yes, 2019
The mitochondrial ADP/ATP carrier (AAC) is a major transport protein of the inner mitochondrial membrane. It exchanges mitochondrial ATP for cytosolic ADP and controls cellular production of ATP.
Angelin, Alessia   +12 more
core   +1 more source

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