Results 31 to 40 of about 63,943 (301)

Genetic predisposition to porto‐sinusoidal vascular disorder: A functional genomic‐based, multigenerational family study

Hepatology, EarlyView., 2022
A deleterious variant of FCHSD1 results in mTOR pathway overactivation and may cause porto‐sinusoidal vascular disorder (PSVD). The pedigree of the family demonstrated an autosomal dominant disease with variable expressivity. Whole‐genome sequencing and Sanger sequencing both validated the existence of the FCHSD1 variant and the heterozygosity of c ...
Jingxuan Shan, André Megarbane, Aziz Chouchane, Deepak Karthik, Ramzi Temanni, Atilio Reyes Romero, Huiying Hua, Chun Pan, Xixi Chen, Murugan Subramanian, Chadi Saad, Hamdi Mbarek, Cybel Mehawej, Eliane Chouery, Sirin W. Abuaqel, Alexander Dömling, Sami Remadi, Cesar Yaghi, Pu Li, Lotfi Chouchane   +19 more
wiley   +1 more source

The hypoxic tissue microenvironment as a driver of mucosal inflammatory resolution

Frontiers in Immunology, 2023
On the backdrop of all acute inflammatory processes lies the activation of the resolution response. Recent years have witnessed an emerging interest in defining molecular factors that influence the resolution of inflammation.
Ian M. Cartwright, Ian M. Cartwright, Ian M. Cartwright, Ian M. Cartwright, Sean P. Colgan, Sean P. Colgan, Sean P. Colgan, Sean P. Colgan   +7 more
doaj   +1 more source

The Suppressor of AAC2 Lethality SAL1 Modulates Sensitivity of Heterologously Expressed Artemia ADP/ATP Carrier to Bongkrekate in Yeast [PDF]

, 2013
The ADP/ATP carrier protein (AAC) expressed in Artemia franciscana is refractory to bongkrekate. We generated two strains of Saccharomyces cerevisiae where AAC1 and AAC3 were inactivated and the AAC2 isoform was replaced with Artemia AAC containing a ...
Adam-Vizi, Vera, Monika Wysocka-Kapcinska (368157), Christos Chinopoulos (317665), Roza Kucharczyk (141980), Christos Chinopoulos, Cynthia L David, Chinopoulos Christos, Hunt AM, Vekey, Karoly, Beata Torocsik (317661), Hunt Andrea M., Roza Kucharczyk, Karoly Vekey (5656285), Kucharczyk Roza, Wysocka-Kapcinska M, Cynthia L. David, Vera Adam-Vizi (317663), Vékey Károly, Cynthia L. David (461150), Törőcsik Beáta, Ádám Veronika, Monika Wysocka-Kapcinska, Andrea M. Hunt, Wysocka-Kapcinska, Monika, Lilla Turiak, Tsaprailis, George, David Cynthia L., Törőcsik, Beáta, Turiák, Lilla, Tsaprailis George, Andrea M. Hunt (461151), Wysocka-Kapcinska Monika, Beata Torocsik, Vera Adam-Vizi, George Tsaprailis (268492), Ádám, Veronika, Kucharczyk R, Andrea M Hunt, David CL, George Tsaprailis, Tsaprailis G, Chinopoulos, Christos, Turiák Lilla, Hunt, Andrea M., Lilla Turiak (5656282), Kucharczyk, Roza, David, Cynthia L., Karoly Vekey, Adam-Vizi Vera   +48 more
core   +1 more source

Brain injury alters ectonucleotidase activities and adenine nucleotide levels in rat serum [PDF]

Journal of Medical Biochemistry, 2015
Background: Cortical stab injury (CSI) induces changes in the activity, expression and cellular distribution of specific ectonucleotidases at the injury site.
Laketa Danijela, Savić Jasmina, Bjelobaba Ivana, Lavrnja Irena, Vasić Vesna, Stojiljković Mirjana, Nedeljković Nadežda   +6 more
doaj  

Multiple Mechanisms Regulate Eukaryotic Cytochrome C Oxidase

Cells, 2021
Cytochrome c oxidase (COX), the rate-limiting enzyme of mitochondrial respiration, is regulated by various mechanisms. Its regulation by ATP (adenosine triphosphate) appears of particular importance, since it evolved early during evolution and is still ...
Rabia Ramzan, Bernhard Kadenbach, Sebastian Vogt   +2 more
doaj   +1 more source

Differential sensitivity and specificity of Aedes aegypti and Anopheles gambiae to adenine nucleotide phagostimulants—an all-or-none response?

Parasites & Vectors
Background The decision to imbibe a blood meal is predominantly dependent on the sensitivity and specificity of haematophagous arthropods to blood-derived adenine nucleotides, in particular adenosine triphosphate (ATP).
Matthew Lukenge, Rickard Ignell, Sharon Rose Hill   +2 more
doaj   +1 more source

Effects of high glucose on adenine nucleotides.

, 2015
Data are means ± SEM (n = 4–5/group). Nucleotide values are expressed as nmol/mg muscle.Effects of high glucose on adenine nucleotides.
Gregory J. Cooney (183923), Edward W. Kraegen (183918), Vera Schultz (743022), Rudy J. Valentine (743020), Asish K. Saha (743024), Kimberly A. Coughlan (743018), Amanda Brandon (743023), Robert Petrocelli (743021), Neil B. Ruderman (172181), Thomas W. Balon (743019)   +9 more
core   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Editorial for the Special Issue Titled “Adenosine Metabolism: Key Targets in Cardiovascular Pharmacology”

Pharmaceuticals
Adenine nucleotides and adenosine maintain cardiovascular homeostasis, producing diverse effects by intracellular and extracellular mechanisms [...]
Barbara Kutryb-Zając
doaj   +1 more source

Intramitochondrial adenine nucleotides and energy-linked functions of heart mitochondria

, 1981
Isolated rabbit heart mitochondria were incubated with varying amounts of inorganic pyrophosphate in 250 mM sucrose to specifically decrease the pool size of endogenous adenine nucleotides.
L. A. Sordahl, G. K. Asimakis
core   +1 more source