Results 31 to 40 of about 123,381 (324)

Structural Basis of SARS-CoV-2 Polymerase Inhibition by Favipiravir

The Innovation, 2021
Summary: The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has developed into an unprecedented global pandemic. Nucleoside analogs, such as Remdesivir and Favipiravir, can serve as the first-line broad-spectrum antiviral drugs ...
Qi Peng, Ruchao Peng, Bin Yuan, Min Wang, Jingru Zhao, Lifeng Fu, Jianxun Qi, Yi Shi   +7 more
doaj   +1 more source

CapZyme-Seq: A 5′-RNA-Seq Method for Differential Detection and Quantitation of NAD-Capped and Uncapped 5′-Triphosphate RNA

STAR Protocols, 2020
Summary: Nucleoside-containing metabolites such as the oxidized and reduced forms of nicotinamide adenine dinucleotide (NAD+ and NADH), 3′-desphospho-coenzyme A (dpCoA), and flavin adenine dinucleotide (FAD) can be incorporated as RNA 5′ end caps by ...
Irina O. Vvedenskaya, Bryce E. Nickels
doaj   +1 more source

Substrate Nucleotide-Determined Non-Templated Addition of Adenine by Taq DNA Polymerase: Implications for PCR-Based Genotyping and Cloning

BioTechniques, 1996
The Applied Biosystems PRISMTM fluorescence-based genotyping system as well as the Invitrogen TA Cloning® vector system are influenced by the tendency of Taq DNA polymerase to add an adenine nucleotide to the 3′ end of PCR products after extension ...
V.L. Magnuson, D.S. Ally, S.J. Nylund, Z.E. Karanjawala, J.B. Rayman, J.I. Knapp, A.L. Lowe, S. Ghosh, F.S. Collins   +8 more
doaj   +1 more source

Determination of total potentially available nucleosides in bovine milk [PDF]

, 2010
Bovine colostrum and milk samples were collected from two herds over the course of the first month post-partum, pooled for each herd by stage of lactation and total potentially available nucleosides were determined.
Gill, Brendon D., Indyk, Harvey E., Manley-Harris, Merilyn   +2 more
core   +2 more sources

The hypoxic tissue microenvironment as a driver of mucosal inflammatory resolution

Frontiers in Immunology, 2023
On the backdrop of all acute inflammatory processes lies the activation of the resolution response. Recent years have witnessed an emerging interest in defining molecular factors that influence the resolution of inflammation.
Ian M. Cartwright, Ian M. Cartwright, Ian M. Cartwright, Ian M. Cartwright, Sean P. Colgan, Sean P. Colgan, Sean P. Colgan, Sean P. Colgan   +7 more
doaj   +1 more source

Gastroprotective effects of oral nucleotide administration [PDF]

, 2006
BACKGROUND AND AIMS: Nucleotides form the building blocks of DNA and are marketed as dietary supplements, alone or in combination with other ingredients, to promote general health.
Belo, A, Fitzgerald, A, Ghosh, S, Marchbank, T, Playford, RJ   +4 more
core   +2 more sources

Sulfonylation sites for adenine and its nucleosides/nucleotides

Journal of Pharmaceutical Analysis
Sulfonylation is extensively used to label DNA and RNA, assess their interactions, and quantify components including nucleobases and nucleosides/nucleotides although the sulfonylation sites remain controversial.
Xiaoyue Cheng, Pengcheng Li, Li Xu, Congcong Zhang, Qi Wang, Huiru Tang   +5 more
doaj   +1 more source

Brain injury alters ectonucleotidase activities and adenine nucleotide levels in rat serum [PDF]

Journal of Medical Biochemistry, 2015
Background: Cortical stab injury (CSI) induces changes in the activity, expression and cellular distribution of specific ectonucleotidases at the injury site.
Laketa Danijela, Savić Jasmina, Bjelobaba Ivana, Lavrnja Irena, Vasić Vesna, Stojiljković Mirjana, Nedeljković Nadežda   +6 more
doaj  

Multiple Mechanisms Regulate Eukaryotic Cytochrome C Oxidase

Cells, 2021
Cytochrome c oxidase (COX), the rate-limiting enzyme of mitochondrial respiration, is regulated by various mechanisms. Its regulation by ATP (adenosine triphosphate) appears of particular importance, since it evolved early during evolution and is still ...
Rabia Ramzan, Bernhard Kadenbach, Sebastian Vogt   +2 more
doaj   +1 more source

Absence of Ca2+-induced mitochondrial permeability transition but presence of bongkrekate-sensitive nucleotide exchange in C. crangon and P. serratus. [PDF]

PLoS ONE, 2012
Mitochondria from the embryos of brine shrimp (Artemia franciscana) do not undergo Ca(2+)-induced permeability transition in the presence of a profound Ca(2+) uptake capacity. Furthermore, this crustacean is the only organism known to exhibit bongkrekate-
Csaba Konrad, Gergely Kiss, Beata Torocsik, Vera Adam-Vizi, Christos Chinopoulos   +4 more
doaj   +1 more source