Results 31 to 40 of about 87,339 (215)

Corrigendum to "Quantitative UPLC-MS/MS assay of urinary 2,8-dihydroxyadenine for diagnosis and management of adenine phosphoribosyltransferase deficiency" [J. Chromatogr. B 1036-1037 (2016) 170-177]. [PDF]

J Chromatogr B Analyt Technol Biomed Life Sci, 2018
Thorsteinsdottir M, Thorsteinsdottir UA, Eiriksson FF, Runolfsdottir HL, Agustsdottir IMS, Oddsdottir S, Sigurdsson BB, Hardarson HK, Kamble NR, Sigurdsson ST, Edvardsson VO, Palsson R.   +11 more
europepmc   +3 more sources

Adenine Phosphoribosyltransferase from Monkey Liver

Journal of Biological Chemistry, 1969
T A Krenitsky, S M Neil, G B Elion, G H Hitchings   +3 more
openaire   +2 more sources

Enhanced mitochondrial activity reshapes a gut microbiota profile that delays NASH progression

Hepatology, EarlyView., 2022
Improved mitochondrial activity, due to the lack of methylation‐controlled J protein (MCJ), creates a specific microbiota signature that when transferred through cecal microbiota transplantation delays NASH progression by restoring the gut‐liver axis and enhancing hepatic fatty acid oxidation.
María Juárez‐Fernández, Naroa Goikoetxea‐Usandizaga, David Porras, María Victoria García‐Mediavilla, Miren Bravo, Marina Serrano‐Maciá, Jorge Simón, Teresa C. Delgado, Sofía Lachiondo‐Ortega, Susana Martínez‐Flórez, Óscar Lorenzo, Mercedes Rincón, Marta Varela‐Rey, Leticia Abecia, Héctor Rodríguez, Juan Anguita, Esther Nistal, María Luz Martínez‐Chantar, Sonia Sánchez‐Campos   +18 more
wiley   +1 more source

Synthesis of bis-Phosphate Iminoaltritol Enantiomers and Structural Characterization with Adenine Phosphoribosyltransferase. [PDF]

ACS Chem Biol, 2018
Harris LD, Harijan RK, Ducati RG, Evans GB, Hirsch BM, Schramm VL.   +5 more
europepmc   +2 more sources

Inhibition of nicotinamide phosphoribosyltransferase, the rate-limiting enzyme of the nicotinamide adenine dinucleotide salvage pathway, to target glioma heterogeneity through mitochondrial oxidative stress.

Neuro-Oncology, 2021
BACKGROUND Tumor-specific metabolic processes essential for cell survival are promising targets to potentially circumvent intratumoral heterogeneity, a major resistance factor in gliomas.
Pratibha Sharma, Jihong Xu, Katie E. Williams, Michelle Easley, J. Elder, R. Lonser, F. Lang, R. Lapalombella, D. Sampath, V. Puduvalli   +9 more
semanticscholar   +1 more source

2,8-Dihydroxyadenine nephrolithiasis with chronic kidney disease in children: A case report and review of literature

Urology Case Reports, 2023
The incidence of nephrolithiasis in children ranges from 5 to 10% in developing countries. Etiology of nephrolithiasis in children remains largely unknown, so metabolic evaluation is indicated in all case, because of potential morbidity and recurrence ...
Rizky Ramdhani, Akhmad Mustafa, Safendra Siregar, Jupiter Sibarani, Tjahjodjati Tjahjodjati, Ahmedz Widiasta, Rini Rossanti   +6 more
doaj   +1 more source

A Novel One-Pot Enzyme Cascade for the Biosynthesis of Cladribine Triphosphate

Biomolecules, 2021
Cladribine triphosphate is the active compound of the anti-cancer and multiple sclerosis drug Mavenclad (cladribine). Biosynthesis of such non-natural deoxyribonucleotides is challenging but important in order to study the pharmaceutical modes of action.
Julia Frisch, Tin Maršić, Christoph Loderer   +2 more
doaj   +1 more source

Recent Advances in NAMPT Inhibitors: A Novel Immunotherapic Strategy

Frontiers in Pharmacology, 2020
Nicotinamide adenine dinucleotide (NAD) is a cofactor of many enzymatic reactions as well as being a substrate for a number of NAD-consuming enzymes (e.g., PARPS, sirtuins, etc).
Ubaldina Galli, Giorgia Colombo, Cristina Travelli, Gian Cesare Tron, Armando A. Genazzani, Ambra A. Grolla   +5 more
doaj   +1 more source

Inflammation plays a critical role in 2,8-dihydroxyadenine nephropathy

Comptes Rendus. Chimie, 2021
Adenine phosphoribosyltransferase (APRT) deficiency is a genetic disease characterized by an increased production of 2,8 dihydroxyadenine (2,8-DHA) precipitating in urine, leading to a crystalline nephropathy and end-stage renal disease.
Bouderlique, Elise, Tang, Ellie, Perez, Joëlle, Ea, Hang-Korng, Renaudin, Felix, Coudert, Amélie, Vandermeersch, Sophie, Bazin, Dominique, Haymann, Jean-Philippe, Saint-Jacques, Camille, Frochot, Vincent, Daudon, Michel, Letavernier, Emmanuel   +12 more
doaj   +1 more source

Quantitative UPLC-MS/MS assay of urinary 2,8-dihydroxyadenine for diagnosis and management of adenine phosphoribosyltransferase deficiency. [PDF]

J Chromatogr B Analyt Technol Biomed Life Sci, 2016
Thorsteinsdottir M, Thorsteinsdottir UA, Eiriksson FF, Runolfsdottir HL, Agustsdottir IM, Oddsdottir S, Sigurdsson BB, Hardarson HK, Kamble NR, Sigurdsson ST, Edvardsson VO, Palsson R.   +11 more
europepmc   +2 more sources