Results 31 to 40 of about 6,350 (165)

Efficient one-pot synthesis, molecular docking and in silico ADME prediction of bis-(4-hydroxycoumarin-3-yl) methane derivatives as antileishmanial agents [PDF]

, 2015
Bis-(4-hydroxycoumarin-3-yl) methane derivatives 3(a-l) were synthesized from 4-hydroxycoumarin and substituted aromatic aldehydes using succinimide-N-sulfonic acid as catalyst and evaluated for their in vitro antileishmanial activity against ...
Khan, Firoz A. Kalam, Patil, Rajendra H., Sangshetti, Jaiprakash N., Zaheer, Zahid   +3 more
core   +1 more source

Trypanosoma brucei adenine-phosphoribosyltransferases mediate adenine salvage and aminopurinol susceptibility but not adenine toxicity [PDF]

International Journal for Parasitology: Drugs and Drug Resistance, 2014
African trypanosomes, like all obligate parasitic protozoa, cannot synthesize purines de novo and import purines from their hosts to build nucleic acids. The purine salvage pathways of Trypanosoma brucei being redundant, none of the involved enzymes is likely to be essential.
Lüscher, Alexandra, Lamprea-Burgunder, Estelle, Graf, Fabrice E., De Koning, Harry, Mäser, Pascal   +4 more
openaire   +4 more sources

Adenine phosphoribosyltransferase deficiency and 2, 8-dihydroxyadenine renal stones: A preventable cause of pediatric renal stones and kidney disease

Saudi Journal of Kidney Diseases and Transplantation, 2019
Adenine phosphoribosyltransferase deficiency is an inherited condition presenting from infancy to late adulthood. The common features are recurrent kidney and urinary tract stones and obstructive symptoms. The stones are characteristically radiolucent. 2,
Mital Dipakkkumar Parikh, Abhijit Konnur, Sishir Gang   +2 more
doaj   +1 more source

Thermophilic phosphoribosyltransferases Thermus thermophilus HB27 in nucleotide synthesis

Beilstein Journal of Organic Chemistry, 2018
Phosphoribosyltransferases are the tools that allow the synthesis of nucleotide analogues using multi-enzymatic cascades. The recombinant adenine phosphoribosyltransferase (TthAPRT) and hypoxanthine phosphoribosyltransferase (TthHPRT) from Thermus ...
Ilja V. Fateev, Ekaterina V. Sinitsina, Aiguzel U. Bikanasova, Maria A. Kostromina, Elena S. Tuzova, Larisa V. Esipova, Tatiana I. Muravyova, Alexei L. Kayushin, Irina D. Konstantinova, Roman S. Esipov   +9 more
doaj   +1 more source

Induction of adenine salvage in mouse cell lines deficient in adenine phosphoribosyltransferase. [PDF]

Molecular and Cellular Biology, 1985
Adenine phosphoribosyltransferase (APRT) (EC 2.4.2.7) pseudorevertant cell lines were isolated under selective conditions requiring adenine salvage for survival; yet they were found to be deficient in measurable APRT activity and resistant to the purine analog 2'6'-diaminopurine (DAP) (M.S. Turker, J. A. Tischfield, P. Rabinovitch, P.J. Stambrook, J.J.
George M. Martin, Mitchell S. Turker
openaire   +2 more sources

HPRTSardinia: a new point mutation causing HPRT deficiency without Lesch–Nyhan disease [PDF]

, 2006
Hypoxanthine-guanine phosphoribosyltransferase (HPRT) deficiency always causing hyperuricemia presents various degrees of neurological manifestations, the most severe which is Lesch–Nyhan syndrome.
Carcassi, Aldo, Carcassi, Carlo, Contu, Licinio, Corradi, Maria Rita, Cossu, Antonello, Jacomelli, Gabriella, Micheli, Vanna, Orrù, Sandro, Pompucci, Giuseppe, Sestini, Silvia   +9 more
core   +1 more source

Copper ions inhibit pentose phosphate pathway function in Staphylococcus aureus.

PLoS Pathogens, 2023
To gain a better insight of how Copper (Cu) ions toxify cells, metabolomic analyses were performed in S. aureus strains that lacks the described Cu ion detoxification systems (ΔcopBL ΔcopAZ; cop-).
Javiera Norambuena, Hassan Al-Tameemi, Hannah Bovermann, Jisun Kim, William N Beavers, Eric P Skaar, Dane Parker, Jeffrey M Boyd   +7 more
doaj   +1 more source

Quinolinate Phosphoribosyltransferase Promotes Invasiveness of Breast Cancer Through Myosin Light Chain Phosphorylation

Frontiers in Endocrinology, 2021
Perturbed Nicotinamide adenine dinucleotide (NAD+) homeostasis is involved in cancer progression and metastasis. Quinolinate phosphoribosyltransferase (QPRT) is the rate-limiting enzyme in the kynurenine pathway participating in NAD+ generation.
Chien-Liang Liu, Chien-Liang Liu, Chien-Liang Liu, Shih-Ping Cheng, Shih-Ping Cheng, Shih-Ping Cheng, Ming-Jen Chen, Ming-Jen Chen, Ming-Jen Chen, Chi-Hsin Lin, Chi-Hsin Lin, Shan-Na Chen, Yi-Hue Kuo, Yuan-Ching Chang, Yuan-Ching Chang, Yuan-Ching Chang   +15 more
doaj   +1 more source

MicroRNA410 Inhibits Pulmonary Vascular Remodeling via Regulation of Nicotinamide Phosphoribosyltransferase [PDF]

, 2019
Nicotinamide phosphoribosyltransferase (NAMPT) upregulation in human pulmonary artery endothelial cells (hPAECs) is associated with pulmonary arterial hypertension (PAH) progression and pulmonary vascular remodeling.
Chen, Jiwang, Chen, Tianji, Dong, Yangbasai, Gao, Hui, Machado, Roberto F., Song, Yang, Wang, Yifang, Zhao, Shuangping   +7 more
core   +1 more source

Recurrent 2,8-Dihydroxyadenine Crystalline Nephropathy in Renal Allograft

Annals of Internal Medicine: Clinical Cases
Adenine phosphoribosyltransferase deficiency is a rare cause of crystalline kidney disease. We present a case of end-stage kidney disease secondary to crystal deposition from adenine phosphoribosyltransferase deficiency with immediate recurrence of the ...
Farid Arman, Russell John Crew, Michael Barry Stokes, Jai Radhakrishnan   +3 more
doaj   +1 more source