Results 41 to 50 of about 87,339 (215)

Research Advances in Purine Phosphoribosyltransferases of Protozoan Parasites

Guangdong nongye kexue, 2023
Parasitic protozoa are single-celled organisms that have adapted to live in cells of humans and animals. The protozoan parasites include Leishmania spp., Trypanosoma spp., Plasmodium spp., Toxoplasma gondii, Cryptosporidium spp., and Eimeria spp., which ...
Zhihui YU, Siyun FANG, Mingfei SUN, Nanshan QI, Wenjun LIU, Juan LI, Junjing HU, Shenquan LIAO   +7 more
doaj   +1 more source

Use of LightCycler mutation analysis to detect type II adenine phosphoribosyltransferase deficiency in two patients with 2,8-dihydroxyadeninuria. [PDF]

CEN Case Rep, 2016
Ikeda H, Watanabe T, Toyama D, Isoyama K.   +3 more
europepmc   +3 more sources

From Rate-Limiting Enzyme to Therapeutic Target: The Promise of NAMPT in Neurodegenerative Diseases

Frontiers in Pharmacology, 2022
Nicotinamide phosphoribosyltransferase (NAMPT) is the rate-limiting enzyme in the nicotinamide adenine dinucleotide (NAD) salvage pathway in mammals. It is of great significance in the metabolic homeostasis and cell survival via synthesizing nicotinamide
Yumeng Zhu, Ping Xu, Xuan Huang, Wen Shuai, Li Liu, Shuai Zhang, Rui Zhao, Xiuying Hu, Guan Wang   +8 more
doaj   +1 more source

Inhibition of nicotinamide phosphoribosyltransferase and depletion of nicotinamide adenine dinucleotide contribute to arsenic trioxide suppression of oral squamous cell carcinoma

Toxicology and Applied Pharmacology, 2017
Cecilia Wang, Jin Zhi Wang, Lu Gao, Fu Yin Zhang, Qi Wang, Ke Jian Liu, Bin Xiang   +6 more
openalex   +3 more sources

Molecular docking investigation of the amantadine binding to the enzymes upregulated or downregulated in Parkinson’s disease

ADMET and DMPK, 2020
Parkinson’s disease (PD) is a progressive neurodegenerative disease. Levodopa in combination with amantadine has a demonstrated efficacy in motility impairment. An extensive investigation of some enzymes described to be upregulated or downregulated in PD
Mihaela Ileana Ionescu
doaj   +1 more source

Huangqi-Danshen decoction protects against cisplatin-induced acute kidney injury in mice

Frontiers in Pharmacology, 2023
Background: Acute kidney injury (AKI) induced by cisplatin remains a major impediment to the clinical application of cisplatin, necessitating urgent exploration for promising solutions.
Xinhui Liu, Liwen Gao, Xi Huang, Ruyu Deng, Shanshan Wu, Yu Peng, Jiandong Lu   +6 more
doaj   +1 more source

Rare forms of nephrolithiasis

Pediatria i Medycyna Rodzinna, 2019
Inborn errors of metabolism that may lead to calculus formation within the urinary tract include: adenine phosphoribosyltransferase deficiency, xanthine oxidase deficiency, orotic aciduria (acidosis) type I and alkaptonuria.
Piotr Skrzypczyk, Małgorzata Pańczyk-Tomaszewska   +1 more
doaj   +1 more source

Genome Analysis of Nicotinamide Adenine Dinucleotide-Independent Mycoplasma synoviae Isolates From Korea

Pathogens, 2021
Mycoplasma synoviae (MS) is an avian pathogen that causes respiratory disease, infectious synovitis, and eggshell apex abnormalities in chickens. Nicotinamide adenine dinucleotide (NAD)-independent MS was first reported in 1975.
Yongjun Song, Tae-Min La, Taesoo Kim, Gyuhee Ahn, Won Hur, Hong-Jae Lee, Hyunjin Shin, Seung-un Song, Eunjin Park, Joong-Bok Lee, Seung-Yong Park, In-Soo Choi, Sang-Won Lee   +12 more
doaj   +1 more source

Selective killing of tumors deficient in methylthioadenosine phosphorylase: a novel strategy. [PDF]

PLoS ONE, 2009
BACKGROUND:The gene for methylthioadenosine phosphorylase (MTAP) lies on 9p21, close to the gene CDKN2A that encodes the tumor suppressor proteins p16 and p14ARF.
Martin Lubin, Adam Lubin
doaj   +1 more source

Maintenance of NAD+ Homeostasis in Skeletal Muscle during Aging and Exercise

Cells, 2022
Nicotinamide adenine dinucleotide (NAD) is a versatile chemical compound serving as a coenzyme in metabolic pathways and as a substrate to support the enzymatic functions of sirtuins (SIRTs), poly (ADP-ribose) polymerase-1 (PARP-1), and cyclic ADP ribose
Li Li Ji, Dongwook Yeo
doaj   +1 more source