Results 51 to 60 of about 6,350 (165)

Exercise training upregulates intracellular nicotinamide phosphoribosyltransferase expression in humans: a systematic review with meta-analysis

Frontiers in Public Health, 2023
ObjectiveAging is associated with decreased nicotinamide adenine dinucleotide (NAD) levels, which in turn cause dysfunctional mitochondria and indirectly affect a myriad of diseases. Intracellular nicotinamide phosphoribosyltransferase (iNAMPT) serves as
Xu Sun, Lide Su, Lide Su, Te Bu, Te Bu, Yang Zhang   +5 more
doaj   +1 more source

NAMPT and NAPRT, Key Enzymes in NAD Salvage Synthesis Pathway, Are of Negative Prognostic Value in Colorectal Cancer

Frontiers in Oncology, 2019
Nicotinamide adenine dinucleotide (NAD) is a profoundly important cofactor in redox reactions. Nicotinamide phosphoribosyltransferase (NAMPT) and nicotinate phosphoribosyltransferase (NAPRT) are key enzymes for NAD salvage biosynthesis pathway, which ...
Xiao-qin Li, Jing Lei, Lin-hong Mao, Qing-liang Wang, Feng Xu, Tao Ran, Zhi-hang Zhou, Song He   +7 more
doaj   +1 more source

Investigating the role of SARM1 in central nervous system

Ibrain, EarlyView.
Sterile‐α and Toll/interleukin 1 receptor (TIR) motif‐containing protein 1 (SARM1) is a pivotal molecule that has garnered extensive attention in neuroscience. As an intracellular molecule, SARM1 possesses various crucial biological functions in the nervous system.
Junjie Wang, Yuhang Shi, Jinglei Tian, Liming Tang, Fang Cao   +4 more
wiley   +1 more source

Target enzyme mutations are the molecular basis for resistance towards pharmacological inhibition of nicotinamide phosphoribosyltransferase [PDF]

, 2010
Background Inhibitors of nicotinamide phosphoribosyltransferase (NAMPT) are promising cancer drugs currently in clinical trials in oncology, including APO866, CHS-828 and the CHS-828 prodrug EB1627/GMX1777, but cancer cell resistance to these drugs has ...
A Formentini, A Garten, A Nahimana, A Ravaud, AA Sauve, Annemette V Thougaard, Antje Garten, C Lengauer, C Mattos, C Schou, F Nomura, Fredrik Björkling, G Kroemer, GB Kang, GC Elliott, GJ Hageman, GJ Peters, J Diefenbach, J Gullbo, JA Khan, JA Khan, Jakob G Petersen, JB Clark, JR Revollo, JR Revollo, JR Revollo, Jun Yoshino, K Holen, LR Saunders, LS Olsen, M Hasmann, M Pishvaian, M Watson, M Ziegler, Maxwell Sehested, MD Jackson, ME Gorre, ME Gorre, Mette K Christensen, MK Kim, P Hovstadius, P Hovstadius, P Martinsson, PA Janne, PB Jensen, Peter B Jensen, Peter Fristrup, PJ Hjarnaa, SB Hassan, Shin-Ichiro Imai, Søren J Nielsen, T O'Hare, T Wang, U Galli, Uffe H Olesen, UH Olesen, UH Olesen, Wieland Kiess   +57 more
core   +5 more sources

Harmonizing NAD+ metabolism with CeMOF nanozyme to orchestrate intraocular pressure modulation for glaucoma treatment

VIEW, EarlyView.
Our findings demonstrate that NAD+ metabolism dysregulation contributes to elevated intraocular pressure in glaucoma. Supplementation with NAD+ precursors reduces IOP by alleviating oxidative stress, cellular senescence, and extracellular matrix deposition.
Youjia Zhang, Ming Chen, Yi Tian, Bo Qin, Xiaoxiao Chen, Yiwen Zhou, Jinhai Huang, Mei Yang, Xinghuai Sun, Yuan Lei, Yuhong Chen   +10 more
wiley   +1 more source

In-silico gene essentiality analysis of polyamine biosynthesis reveals APRT as a potential target in cancer

, 2017
Constraint-based modeling for genome-scale metabolic networks has emerged in the last years as a promising approach to elucidate drug targets in cancer.
Agirre, Xabier, Apaolaza, Iñigo, Atauri, Pedro de, Carracedo, Arkaitz, Cascante i Serratosa, Marta, Cendoya, Xabier, Garate, Leire, Miranda, Estíbaliz, Ochoa, María Carmen, Pey, Jon, Planes, Francisco J., Prosper, Felipe, Rubio, Angel, San José-Eneriz, Edurne   +13 more
core   +3 more sources

Improved cytotoxic effects of Salmonella-producing cytosine deaminase in tumour cells [PDF]

, 2016
This is an open access article under the terms of the Creative Commons Attribution License.In order to increase the cytotoxic activity of a Salmonella strain carrying a salicylate-inducible expression system that controls cytosine deaminase production ...
Camacho, Eva María, Flores, Amando, Medina, Carlos, Mesa-Pereira, Beatriz, Santero, Eduardo   +4 more
core   +1 more source

Chronic Cellular NAD Depletion Activates a Viral Infection‐Like Interferon Response Through Mitochondrial DNA Leakage

Aging Cell, EarlyView.
Chronic NAD depletion in fibroblasts lowers NAD levels, increases mitochondrial mass, and triggers an interferon‐dependent inflammatory response via mtDNA leakage through VDAC1, activating the cGAS‐STING pathway. This links NAD deficiency to metabolic and inflammatory processes, with implications for diseases associated with NAD decline.
Claudia C. S. Chini, Laura Colman, Eduardo Palmieri, Jessica L. Strange, Sonu Kashyap, Bing Han, Andres Benitez‐Rosendo, Gina L. Ciccio Lopez, Sara Peixoto Rabelo, Shreyartha Mukherjee, Gustavo H. de Souza, John Varga, Ralph G. Meyer, Mirella L. Meyer‐Ficca, Eduardo N. Chini   +14 more
wiley   +1 more source

Pharmacology and clinical drug candidates in redox medicine [PDF]

, 2015
SIGNIFICANCE Oxidative stress is suggested to be a disease mechanism common to a wide range of disorders affecting human health. However, so far, the pharmacotherapeutic exploitation of this, for example, based on chemical scavenging of pro-oxidant ...
Casas, Ana I, Cuadrado, Antonio, Dao, V Thao-Vi, Di Lisa, Fabio, Ghezzi, Pietro, Jaquet, Vincent, Kaludercic, Nina, Maghzal, Ghassan J, Robledinos-Anton, Natalia, Schmidt, Harald H H W, Seredenina, Tamara, Stocker, Roland   +11 more
core   +2 more sources

The NAMPT Inhibitor FK866 in Combination with Cisplatin Reduces Cholangiocarcinoma Cells Growth

Cells, 2023
It is well established that Cholangiocarcioma (CCA) drug resistance plays a crucial role in the spread and survival of cancer cells.
Kishor Pant, Seth Richard, Estanislao Peixoto, Jun Yin, Davis M. Seelig, Pietro Carotenuto, Massimiliano Salati, Brunella Franco, Lewis R. Roberts, Sergio A. Gradilone   +9 more
doaj   +1 more source