Results 51 to 60 of about 87,339 (215)

Properly Substituted Benzimidazoles as a New Promising Class of Nicotinate Phosphoribosyltransferase (NAPRT) Modulators

Pharmaceuticals, 2023
The prevention of nicotinamide adenine dinucleotide (NAD) biosynthesis is considered an attractive therapeutic approach against cancer, considering that tumor cells are characterized by an increased need for NAD to fuel their reprogrammed metabolism.
Cecilia Baldassarri, Gianfabio Giorgioni, Alessandro Piergentili, Wilma Quaglia, Stefano Fontana, Valerio Mammoli, Gabriele Minazzato, Elisa Marangoni, Massimiliano Gasparrini, Leonardo Sorci, Nadia Raffaelli, Loredana Cappellacci, Riccardo Petrelli, Fabio Del Bello   +13 more
doaj   +1 more source

NAD+ metabolism controls inflammation during senescence

Molecular & Cellular Oncology, 2019
We have recently discovered that nicotinamide adenine dinucleotide metabolism controls the pro-inflammatory senescence-associated secretory phenotype during cellular senescence.
Timothy Nacarelli, Rugang Zhang
doaj   +1 more source

Unusual cause of crystalline nephropathy

Saudi Journal of Kidney Diseases and Transplantation, 2018
Adenine phosphoribosyltransferase deficiency is a rare, inherited autosomal recessive disease presenting with 2,8-dihydroxyadenine (DHA) urolithiasis, DHA nephropathy, and chronic kidney disease.
Natarajan Gopalakrishnan, Dhanasekaran Rajasekar, Jeyachandran Dhanapriya, Thanigachalam Dineshkumar, Ramanathan Sakthirajan, T Balasubramaniyan, V Murugesan   +6 more
doaj   +1 more source

Ability of metformin to deplete NAD+ contributes to cancer cell susceptibility to metformin cytotoxicity and is dependent on NAMPT expression

Frontiers in Oncology, 2023
BackgroundNicotinamide adenine dinucleotide (NAD+) is vital for not only energy metabolism but also signaling pathways. A major source of NAD+ depletion is the activation of poly (ADP-ribose) polymerase (PARP) in response to DNA damage.
Yongxian Zhuang, Allison B. Haugrud, Meg A. Schaefer, Meg A. Schaefer, Shanta M. Messerli, W. Keith Miskimins   +5 more
doaj   +1 more source

Nicotinamide Phosphoribosyltransferase (Nampt)/Nicotinamide Adenine Dinucleotide (NAD) Axis Suppresses Atrial Fibrillation by Modulating the Calcium Handling Pathway

International Journal of Molecular Sciences, 2020
Aging and obesity are the most prominent risk factors for onset of atrial fibrillation (AF). Nicotinamide phosphoribosyltransferase (Nampt) is the rate-limiting enzyme that catalyzes nicotinamide adenine dinucleotide (NAD) activity.
D. Feng, DongZhu Xu, N. Murakoshi, K. Tajiri, Rujie Qin, Saori Yonebayashi, Yuta Okabe, Siqi Li, Zixun Yuan, K. Aonuma, M. Ieda   +10 more
semanticscholar   +1 more source

Thermophilic phosphoribosyltransferases Thermus thermophilus HB27 in nucleotide synthesis

Beilstein Journal of Organic Chemistry, 2018
Phosphoribosyltransferases are the tools that allow the synthesis of nucleotide analogues using multi-enzymatic cascades. The recombinant adenine phosphoribosyltransferase (TthAPRT) and hypoxanthine phosphoribosyltransferase (TthHPRT) from Thermus ...
Ilja V. Fateev, Ekaterina V. Sinitsina, Aiguzel U. Bikanasova, Maria A. Kostromina, Elena S. Tuzova, Larisa V. Esipova, Tatiana I. Muravyova, Alexei L. Kayushin, Irina D. Konstantinova, Roman S. Esipov   +9 more
doaj   +1 more source

Copper ions inhibit pentose phosphate pathway function in Staphylococcus aureus.

PLoS Pathogens, 2023
To gain a better insight of how Copper (Cu) ions toxify cells, metabolomic analyses were performed in S. aureus strains that lacks the described Cu ion detoxification systems (ΔcopBL ΔcopAZ; cop-).
Javiera Norambuena, Hassan Al-Tameemi, Hannah Bovermann, Jisun Kim, William N Beavers, Eric P Skaar, Dane Parker, Jeffrey M Boyd   +7 more
doaj   +1 more source

Recurrent 2,8-Dihydroxyadenine Crystalline Nephropathy in Renal Allograft

Annals of Internal Medicine: Clinical Cases
Adenine phosphoribosyltransferase deficiency is a rare cause of crystalline kidney disease. We present a case of end-stage kidney disease secondary to crystal deposition from adenine phosphoribosyltransferase deficiency with immediate recurrence of the ...
Farid Arman, Russell John Crew, Michael Barry Stokes, Jai Radhakrishnan   +3 more
doaj   +1 more source

Quinolinate Phosphoribosyltransferase Promotes Invasiveness of Breast Cancer Through Myosin Light Chain Phosphorylation

Frontiers in Endocrinology, 2021
Perturbed Nicotinamide adenine dinucleotide (NAD+) homeostasis is involved in cancer progression and metastasis. Quinolinate phosphoribosyltransferase (QPRT) is the rate-limiting enzyme in the kynurenine pathway participating in NAD+ generation.
Chien-Liang Liu, Chien-Liang Liu, Chien-Liang Liu, Shih-Ping Cheng, Shih-Ping Cheng, Shih-Ping Cheng, Ming-Jen Chen, Ming-Jen Chen, Ming-Jen Chen, Chi-Hsin Lin, Chi-Hsin Lin, Shan-Na Chen, Yi-Hue Kuo, Yuan-Ching Chang, Yuan-Ching Chang, Yuan-Ching Chang   +15 more
doaj   +1 more source

Dihydroxyadenine crystal-induced nephropathy presenting with rapidly progressive renal failure

Kidney Research and Clinical Practice, 2018
Adenine phosphoribosyltransferase enzyme deficiency is a rare, autosomal recessive disorder. It is a disease limited to the renal system and usually presents with urolithiasis.
Ritu Verma, Manickam Niraimathi, Pallavi Prasad, Vinita Agrawal   +3 more
doaj   +1 more source