Results 81 to 90 of about 87,339 (215)

Metabolomics analysis of metabolic effects of nicotinamide phosphoribosyltransferase (NAMPT) inhibition on human cancer cells. [PDF]

PLoS ONE, 2014
Nicotinamide phosphoribosyltransferase (NAMPT) plays an important role in cellular bioenergetics. It is responsible for converting nicotinamide to nicotinamide adenine dinucleotide, an essential molecule in cellular metabolism. NAMPT has been extensively
Vladimir Tolstikov, Alexander Nikolayev, Sucai Dong, Genshi Zhao, Ming-Shang Kuo   +4 more
doaj   +1 more source

Disruption of Gut Microbiota‐Mediated De Novo NAD+ Synthesis Contributes to the Development of Polycystic Ovary Syndrome

Advanced Science, Volume 12, Issue 45, December 4, 2025.
This study demonstrates that patients with PCOS exhibit altered gut microbial profiles, and FMT from PCOS patients induces PCOS‐like symptoms in mice. Specifically, gut dysbiosis reduces 3‐HAA levels in the context of PCOS. Administration of 3‐HAA to mice alleviates PCOS by promoting de novo NAD+ synthesis.
Ke Chen, Huafeng Geng, Yang Zheng, Hongyang Xie, Rui Qin, Junyang Chen, Cong Ye   +6 more
wiley   +1 more source

Adenine Phosphoribosyltransferase Is a Universal Counterselectable Marker for DNA-Free Genome Editing in Oomycetes

Molecular Plant-Microbe Interactions
CRISPR-Cas genome editing is a powerful tool for understanding the pathogenicity of oomycetes, a group that includes several destructive plant parasites.
Laurent Camborde, Chalisa Jaturapaktrarak, Jérôme Gouzy, Céline Lopez-Roques, Theerapong Krajaejun, Elodie Gaulin, Yacine Badis   +6 more
doaj   +1 more source

Supplementation of Nicotinic Acid with NAMPT Inhibitors Results in Loss of In Vivo Efficacy in NAPRT1-Deficient Tumor Models

Neoplasia: An International Journal for Oncology Research, 2013
Nicotinamide adenine dinucleotide (NAD) is a metabolite essential for cell survival and generated de novo from tryptophan or recycled from nicotinamide (NAM) through the nicotinamide phosphoribosyltransferase (NAMPT)-dependent salvage pathway ...
Thomas O'Brien, Jason Oeh, Yang Xiao, Xiaorong Liang, Alexander Vanderbilt, Ann Qin, Lulu Yang, Leslie B. Lee, Justin Ly, Ely Cosino, Jennifer A. LaCap, Annie Ogasawara, Simon Williams, Michelle Nannini, Bianca M. Liederer, Peter Jackson, Peter S. Dragovich, Deepak Sampath   +17 more
doaj   +1 more source

The Influence of Schwann Cell Metabolism and Dysfunction on Axon Maintenance

Glia, Volume 73, Issue 12, Page 2338-2352, December 2025.
Main Points Sensory neurons depend on Schwann cells for survival. Schwann cells provide energy for axons dunng rapid firing or after injury. Dysregulated metabolism in Schwann cells can lead to the production of neurotoxic and axon degeneration. ABSTRACT Schwann cells are the glial cells in the peripheral nervous system responsible for the production ...
Rose Follis, Vishwanath V. Prabhu, Bruce D. Carter   +2 more
wiley   +1 more source

Trypanosoma brucei adenine-phosphoribosyltransferases mediate adenine salvage and aminopurinol susceptibility but not adenine toxicity [PDF]

International Journal for Parasitology: Drugs and Drug Resistance, 2014
African trypanosomes, like all obligate parasitic protozoa, cannot synthesize purines de novo and import purines from their hosts to build nucleic acids. The purine salvage pathways of Trypanosoma brucei being redundant, none of the involved enzymes is likely to be essential.
Lüscher, Alexandra, Lamprea-Burgunder, Estelle, Graf, Fabrice E., De Koning, Harry, Mäser, Pascal   +4 more
openaire   +3 more sources

Risk Factors for Cardiovascular and Metabolic Disease: Integrating Traditional and Novel Paradigms

iNew Medicine, Volume 1, Issue 1, December 2025.
ABSTRACT Cardiovascular and metabolic diseases (CVMD), encompassing atherosclerotic cardiovascular disease (ASCVD), heart failure, obesity, type 2 diabetes mellitus (T2DM), and metabolic dysfunction‐associated steatotic liver disease (MASLD), remain the leading global cause of morbidity and mortality.
Zhihua Wang, Shuo Chen, Suowen Xu, Jianping Weng   +3 more
wiley   +1 more source

NAD+ Enhanced Mesenchymal Stromal Cells Effect on Muscle Atrophy by Improving SIRT1‐Mediated Mitochondrial Function via NAMPT

Journal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 6, December 2025.
ABSTRACT Background Sarcopenia contributes to all‐cause mortality in the elderly; however, there is no specific treatment. Mesenchymal stromal cells (MSCs) ameliorate age‐related muscle loss and dysfunction and are potential therapeutic candidates for sarcopenia.
Jia Song, Yuting Sun, Nan Zang, Xue Liu, Jiamu Chen, Kewei Wang, Longqing Xia, Jun Chen, Ruxing Zhao, Fuqiang Liu, Xinguo Hou, Li Chen, Jun Cheng, Wenjian Zhang   +13 more
wiley   +1 more source

Synthesizing and salvaging NAD: lessons learned from Chlamydomonas reinhardtii.

PLoS Genetics, 2010
The essential coenzyme nicotinamide adenine dinucleotide (NAD+) plays important roles in metabolic reactions and cell regulation in all organisms. Bacteria, fungi, plants, and animals use different pathways to synthesize NAD+.
Huawen Lin, Alan L Kwan, Susan K Dutcher
doaj   +1 more source

High‐Efficiency Genome Editing of Chlorella sp. by CRISPR/Cas9

Plant Biotechnology Journal, EarlyView.
Xinyu Cui, Yi Xin, Yuan Xiao, Bixin Zhang, Qinhua Gan, Yandu Lu   +5 more
wiley   +1 more source