Results 81 to 90 of about 6,350 (165)

Diagnosis of Inherited Metabolic Disease in Older Patients: A Systematic Literature Review

Journal of Inherited Metabolic Disease, Volume 48, Issue 3, May 2025.
ABSTRACT Inherited metabolic diseases (IMDs) are genetic disorders that disrupt biochemical processes in the human body, due to pathogenic variants in genes encoding enzymes or transporters. While IMDs are mostly diagnosed in infancy or childhood, there is an increasing number of diagnoses in adult patients.
Maria‐Rita Moio, Julia Cordeiro Milke, Yannick Moutapam‐Ngamby‐Adriaansen, Arthur Minas Alberti, Marie Gernay, Eduardo Schütz, Ida Vanessa Doederlein Schwartz, François Maillot   +7 more
wiley   +1 more source

NAD+ Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus [PDF]

, 2015
NAD+ has emerged as a vital cofactor that can rewire metabolism, activate sirtuins, and maintain mitochondrial fitness through mechanisms such as the mitochondrial unfolded protein response. This improved understanding of NAD+ metabolism revived interest
Auwerx, Johan, Cantó, Carles, Menzies, Keir J.   +2 more
core   +1 more source

Reconstitution of Methionine Cycle With ATP Regeneration for Whole‐Cell Catalysis of Creatine Production in Engineered Escherichia coli

Microbial Biotechnology, Volume 18, Issue 5, May 2025.
In this study, we constructed a CR biosynthesis pathway in E. coli by introducing exogenous AGAT and GAMT. We integrated the reconstitution methionine cycle with a polyphosphate kinase‐based ATP regeneration system, achieving a CR titre of 5.27 g/L with a productivity of 0.22 g/L/h.
Yuhua Sheng, Yaokang Wu, Linpei Zhang, Xueqin Lv, Jianghua Li, Long Liu, Guocheng Du, Jian Chen, Yanfeng Liu   +8 more
wiley   +1 more source

Association of circulating levels of nicotinamide phosphoribosyltransferase (NAMPT/Visfatin) and of a frequent polymorphism in the promoter of the NAMPT gene with coronary artery disease in diabetic and non-diabetic subjects [PDF]

, 2013
Background: Nicotinamide phosphoribosyltransferase (NAMPT) is the limiting enzyme in one of pathways of synthesis of Nicotinamide Adenine Dinucleotide, a redox coenzyme.
Crispim, Felipe, Doria, Alessandro, Giuffrida, Fernando de Mello Almada, Lima, Valter Correia de, Oliveira, Carolina Soares, Reis, Andre Fernandes, Saddi-Rosa, Pedro, Velho, Gilberto, Vieira, Jose Gilberto   +8 more
core   +4 more sources

Harnessing nucleotide metabolism and immunity in cancer: a tumour microenvironment perspective

The FEBS Journal, Volume 292, Issue 9, Page 2155-2172, May 2025.
This review explores how changes in nucleotide metabolism affect the tumour microenvironment and immune responses in cancer. Here, we discuss the dual role of nucleotide metabolism in promoting cancer cell growth and shaping immune suppression. We highlight how therapies targeting nucleotide pathways can enhance immunotherapy efficacy, offering new ...
Hadil Suleiman, Alexandra Emerson, Peter M. Wilson, Karl A. Mulligan, Robert D. Ladner, Melissa J. LaBonte   +5 more
wiley   +1 more source

Development and implementation of rapid metabolic engineering tools for chemical and fuel production in Geobacillus thermoglucosidasius NCIMB 11955 [PDF]

, 2017
Background The thermophile Geobacillus thermoglucosidasius has considerable attraction as a chassis for the production of chemicals and fuels. It utilises a wide range of sugars and oligosaccharides typical of those derived from lignocellulose and ...
AH Förster, AH Hussein, AJ Barczak, AJ Wolfe, B Reeve, CM Cooksley, D Mattanovich, DG Olson, E Denamur, EF Bosma, G Bitan-Banin, G Solar Del, G Unden, H Suzuki, I Sastalla, IE Maciag, J Bartosiak-Jentys, J Groom, J Liu, J Zhou, JL Fortman, Josef Altenbuchner, JT Heap, JT Heap, K Zhang, Katalin Kovács, Klaus Winzer, L Boe, L Deng, L González-Segura, L Sheng, Lili Sheng, M Ehsaan, M Matsumura, M Wellington, MP Taylor, MP Taylor, N Knipfer, Nigel Peter Minton, NP Minton, P Gay, P Harris, R Kiewiet, RE Cripps, RE Cripps, RW O’Brien, S Austin, S Bron, S Chang, SA Tripathi, SD Ehrlich, SR Maloy, ST Cartman, ST Cartman, T Sato, T Tanaka, T Yano, V Khetrapal, VI Bashkirov, Ying Zhang, YJ Choi, YK Ng   +61 more
core   +2 more sources

Imeglimin and DPP‐4 inhibitors: A promising therapeutic strategy for type 2 diabetes individuals with reduced insulin secretion

Diabetes, Obesity and Metabolism, Volume 27, Issue 7, Page 4034-4036, July 2025.
Yoshiyuki Hamamoto, Ryota Usui
wiley   +1 more source

NAD+ Metabolism Reprogramming Drives SIRT1‐Dependent Deacetylation Inducing PD‐L1 Nuclear Localization in Cervical Cancer

Advanced Science, Volume 12, Issue 15, April 17, 2025.
The identification of PD‐L1 localization may be a key factor in the resistance to immunotherapy observed in patients. The discovery that PD‐L1 over expression is regulated by both transcriptional and post‐transcriptional processes. The acetyl‐proteomic analysis that identified SIRT1 as a key player in the deacetylation of histone H3 at lysines 27 and ...
Xinyi Lu, Pingping Jin, Qianyun Tang, Min Zhou, Hanjie Xu, Chen Su, Lei Wang, Feng Xu, Min Zhao, Yongxiang Yin, Jinqiu Zhang, Zhen Jia, Xinrui Peng, Jie Zhou, Lu Wang, Yan Chen, Min Wang, Min Yang, Daozhen Chen, Yu Chen   +19 more
wiley   +1 more source

Studies of the Binding of Phosphoribosyl Pyrophosphate to Adenine Phosphoribosyltransferase

Journal of Biological Chemistry, 1970
Abstract The groups on magnesium phosphoribosyl pyrophosphate and on adenine phosphoribosyltransferase which are involved in their binding were investigated by comparing the inhibition constant of magnesium phosphoribosyl pyrophosphate with those of its analogues, by determining the effect of pH on the Michaelis constant of this substrate, and by ...
R.E.A. Gadd, J F Henderson
openaire   +3 more sources

Small Extracellular Vesicle‐Derived Nicotinamide Phosphoribosyltransferase (NAMPT) Induces Acyl‐Coenzyme A Synthetase SLC27A4‐Mediated Glycolysis to Promote Hepatocellular Carcinoma

Journal of Extracellular Vesicles, Volume 14, Issue 4, April 2025.
NAMPT delivered by metastatic HCC cells‐derived sEV upregulates SLC27A4 expression via TLR4/NF‐кB dependent pathway. SLC27A4 acts as an acyl‐CoA synthetase and increases the level of intracellular TG, leading to DHAP‐mediated transition between lipogenesis and glycolysis.
Cherlie Lot Sum Yeung, Tung Him Ng, Charlotte Jiaqi Lai, Tingmao Xue, Xiaowen Mao, Sze Keong Tey, Regina Cheuk Lam Lo, Chun‐Fung Sin, Kwan Ming Ng, Danny Ka Ho Wong, Lung‐Yi Mak, Man‐Fung Yuen, Irene Oi‐Lin Ng, Peihua Cao, Yi Gao, Jing Ping Yun, Judy Wai Ping Yam   +16 more
wiley   +1 more source