Results 201 to 210 of about 70,372 (263)

S100A9 promotes pulmonary arterial hypertension by regulating mitochondria–endoplasmic reticulum interaction‐mediated inflammatory injury of endothelial cells

Interdisciplinary Medicine, EarlyView.
Macrophage‐derived S100 calcium‐binding protein A9 (S100A9) promotes the pathological progression of pulmonary arterial hypertension (PAH). S100A9 upregulates the interaction between signal‐transducing adaptor protein 2 and leucine‐rich repeat kinase 2, thereby regulating mitochondria–endoplasmic reticulum (ER) contact.
Chen Gong, Long Chen, Yiting Zhao, Xiaohe Wang, Qiang Yuan, Xiaofeng Fang, Liuyi Li, Yinbo Xu, Shumei Jiang, Guangwen Xu, Ke Meng, Delong Wang, Kangli Cao, Jianlong Sheng, Liling Guo, Shichun Shen   +15 more
wiley   +1 more source

CapBuild: a cloud-native tool for adeno-associated virus capsid engineering. [PDF]

Nucleic Acids Res
Klein AH, Kuiper MJ, Burgess M, Wickramarachchi A, Jain Y, Bauer DC, Wilson L.   +6 more
europepmc   +1 more source

GSK3β drives early diabetic tubulopathy via TFEB‐mediated mitochondrial dysfunction

Interdisciplinary Medicine, EarlyView.
Mitochondrial dysfunction, including mitochondrial biogenesis, mitophagy, dynamics and oxidative stress, occurs in the early stages of diabetic tubulopathy, which precede proteinuria and renal histological changes. GSK3β is a potential novel biomarker for the prediction of diabetic tubulopathy.
Lan Yao, Xianhui Liang, Bingyu Li, Bohan Chen, Xiaoyang Wang, Mei Hong, Qi Feng, Yingjin Qiao, Zhangsuo Liu, Kai Wang, Pei Wang   +10 more
wiley   +1 more source

Unveiling Small Non-Coding RNA Dynamics During Recombinant Adeno-Associated Virus Production. [PDF]

Biotechnol J
Burkhart M, Langenbach K, Holzmann K, Hornung N, Baiz JA, Otte K.   +5 more
europepmc   +1 more source

pH-dependent DNA degradation pathways for adeno-associated virus gene therapy. [PDF]

Mol Ther Methods Clin Dev
Plegaria JS, Malecka KA, Lin Q, Vogt A, Ausman K, Lopez De Leon A, Petroff M, Barbacci D.   +7 more
europepmc   +1 more source

Role of viral protein ratio in the structure and separation of empty and full adeno-associated virus capsids: A molecular dynamics study. [PDF]

Mol Ther Adv
Valiya Parambathu A, Kumar V, Khanal O, Lenhoff AM.   +3 more
europepmc   +1 more source

Development of an adeno-associated virus vector for gene replacement therapy of NF1-related tumors. [PDF]

Nat Commun
Bai RY, Shi J, Liu J, Sun N, Lu Y, Chen X, Xu M, Lim H, Li Y, Xu H, Weisgerber K, Ren Z, Pratilas CA, Blakeley JO, Fishel ML, Carrió M, Serra E, Staedtke V.   +17 more
europepmc   +1 more source

Novel Human Heart-Derived Natural Adeno-Associated Virus Capsid Combines Cardiospecificity With Cardiotropism In Vivo. [PDF]

Circulation
Zeissler D, Busch M, Grieskamp S, Meinhardt E, Wurzer H, Kulkarni SR, Schrattel AK, Molter S, Kehr D, Qatato M, Rummel C, Hansen A, Loos M, Wrona KM, Völkers M, Kmietczyk V, Wingert J, Dao Thi VL, Hu J, Schlegel P, Dieterich C, Katus HA, Frey N, Jungmann A, Ritterhoff J, Most P.   +25 more
europepmc   +1 more source

A rapid, visual, ultrasensitive and highly specific method for detecting adeno-associated virus 2020 based on the LAMP-CRISPR/Cas12a system. [PDF]

Poult Sci
Gong P, Tao D, Chen Q, Yang Y, Xie S, Chen X, Shi S, Wang Y, Wang L, Qian Y, Ye S.   +10 more
europepmc   +1 more source

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Adeno-associated virus vectors

Current Opinion in Biotechnology, 1992
Adeno-associated virus is a human parvovirus that integrates its DNA genome into host cell chromosomes with very high efficiency. This suggests that adeno-associated virus may be a useful vector for human gene therapy. Interest in adeno-associated virus vectors increased greatly in the last year following reports that adeno-associated virus genome ...
Barrie J Carter, B J Carter
exaly   +3 more sources