Results 221 to 230 of about 8,933,868 (252)

Quantitative Analysis and Predictive Modeling of Nonspecific Adsorption of Recombinant Adeno-Associated Virus onto Solid Surfaces. [PDF]

Langmuir
Ueda Y, Shibuya R, Shibata K, Murai A, Tsunaka Y, Fukuhara M, Uchiyama S.   +6 more
europepmc   +1 more source

Purification and concentration of model viruses using single‐pass tangential flow filtration

Biotechnology Progress, EarlyView.
Single‐pass TFF was developed for an enveloped and non‐enveloped virus for use in continuous downstream purification processes. Enveloped virus was concentrated and purified. Abstract The vaccine and viral vector industry is growing at an accelerated rate.
Luis Alberto Mejía‐Manzano, Lynn Manchester, Grace Wallis, Kan Wang, Bruce P. Lee, Michael Betenbaugh, Caryn L. Heldt   +6 more
wiley   +1 more source

Pervasive horizontal transfer of adeno-associated virus capsid genes. [PDF]

Proc Natl Acad Sci U S A
Gifford RJ.
europepmc   +1 more source

Status and future of recombinant adeno‐associated virus vector manufacturing

Biotechnology Progress, EarlyView.
Abstract Sixty years of adeno‐associated virus (AAV) research illustrates a trajectory marked by basic science exploration, iterative innovation, persistent challenges, a number of clinical setbacks, as well as commercial therapeutic triumphs. This continual evolution has led to recombinant AAV (rAAV) becoming a cornerstone of modern gene therapy ...
Frank Agbogbo, David Dismuke
wiley   +1 more source

Demonstration of nanofiltration‐based virus safety for AAV manufacturing using model viruses

Biotechnology Progress, EarlyView.
Abstract Virus safety for biopharmaceutical products has been a well‐established concern for several decades. While various virus reduction steps have been identified and implemented for traditional plasma‐derived and monoclonal antibody products, there are various challenges to achieving the same virus safety in emerging gene therapy products.
Brian Buesing, Tomoki Igi, Daniel Strauss   +2 more
wiley   +1 more source

A self-complementary recombinant adeno-associated virus vector coding for an anchorless prion protein carrying the G127V mutation extends survival in a rodent prion disease model. [PDF]

PLoS Pathog
Zerbes T, Verkuyl C, Zhang C, Grunnesjoe S, Eid S, Arshad H, Zhao W, Nasser Z, O'Shea T, Bel A, Lamoureux L, Frost KL, Myskiw J, Li LY, Stuart E, Wille H, Booth S, Watts JC, Schmitt-Ulms G.   +18 more
europepmc   +1 more source

Adeno-associated virus delivery of anti-alpha toxin monoclonal antibodies confers protection against Staphylococcus aureus infections. [PDF]

PLoS Pathog
Hommes JW, Hughes ME, Cheung D, Petri B, Orthner LM, van der Linden TJ, Bardoel BW, Deo SK, Patel DT, Flannagan RS, Heinrichs DE, Wootton SK, Surewaard BGJ.   +12 more
europepmc   +1 more source

Intranasal Vaccination with a Recombinant Adeno-Associated Virus Type 6 Encoding SapM Confers Protection Against Tuberculosis. [PDF]

Vaccines (Basel)
Xing C, Wang W, Yang J, Feng S, Xiao J, Cai N, Mo S, Cai Y, Chen X, Shi C.   +9 more
europepmc   +1 more source

Classification and quantification of full vs. empty adeno-associated virus reference capsids via infrared attenuated total reflection spectroscopy. [PDF]

Anal Bioanal Chem
Lehner S, Stach R, Nilson R, Kochanek S, Kritzinger A, Sobek H, Kokoric V, Mizaikoff B.   +7 more
europepmc   +1 more source

Insights into Adeno-Associated Virus Capsid Charge Heterogeneity. [PDF]

Anal Chem
Wu J, Draper BE, Jarrold MF, Heger CD.
europepmc   +1 more source