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Human Gene Therapy, 2009
Recombinant adeno-associated virus (rAAV) holds promise for applications in gene therapy. Advances in clinical studies of rAAV-based gene therapeutics have generated an encouraging momentum in the field of gene therapy; however, one of the major obstacles to the eventual clinical success of rAAV-mediated gene therapy is the need for large-scale ...
Hongwei, Zhang +4 more
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Recombinant adeno-associated virus (rAAV) holds promise for applications in gene therapy. Advances in clinical studies of rAAV-based gene therapeutics have generated an encouraging momentum in the field of gene therapy; however, one of the major obstacles to the eventual clinical success of rAAV-mediated gene therapy is the need for large-scale ...
Hongwei, Zhang +4 more
openaire +2 more sources
Multimodal Production of Adeno-Associated Virus
2019Adeno-associated virus (AAV) is an increasingly popular tool in the research laboratory, and use of this viral vector clinically is occurring at an accelerated pace. Nevertheless, despite its popularity, AAV is a relatively cumbersome virus to produce; however, significant efforts have been invested to develop, optimize, and simplify methodology that ...
Ivette M, Sandoval +2 more
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Generation of Recombinant Adeno-Associated Virus
2003Adeno-associated virus (AAV) was discovered about 30 yr ago as a contaminant of adenovirus preparations. Since its discovery, researchers have described many unique characteristics of AAV biology that have made it attractive as a potential vector for gene therapy.
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Adeno-Associated Virus (AAV) Vectors in the CNS
Current Gene Therapy, 2005Adeno-associated virus (AAV) vectors exhibit a number of properties that have made this vector system an excellent choice for both CNS gene therapy and basic neurobiological investigations. In vivo, the preponderance of AAV vector transduction occurs in neurons where it is possible to obtain long-term, stable gene expression with very little ...
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Optimizing Adeno-Associated Virus Serotype 9 for Studies of Cardiac Chamber–Specific Gene Regulation
Circulation, 2021Christopher C Glembotski +2 more
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The Oncologic Burden of Hepatitis C Virus Infection: A Clinical Perspective
Ca-A Cancer Journal for Clinicians, 2017Felipe Samaniego +2 more
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Targeted Integration by Adeno-Associated Virus
2003Matthew D, Weitzman +3 more
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A Precise Chemical Strategy to Alter the Receptor Specificity of the Adeno-Associated Virus
Angewandte Chemie - International Edition, 2016Raja Mukherjee +2 more
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