Results 221 to 230 of about 214,719 (303)

Manufacture of adeno-associated virus vectors by a novel human-derived cell line HAT and comprehensive evaluation of the vectors. [PDF]

Mol Ther Adv
Tsunaka Y, Fukuhara M, Shimojo S, Matsushita A, Maruno T, Soth S, Nishiumi H, Vergara Rocafort MA, Kuwahara T, Matsumoto K, Shibata K, Nakatsuka R, Asahina R, Mizukado S, Fukai Y, Togashi T, Baatartsogt N, Takeda K, Kuno A, Kashiwakura Y, Yamaguchi Y, Nakamura K, Hirai Y, Hirai H, Ohmori T, Omasa T, Uchiyama S.   +26 more
europepmc   +1 more source

Cannabigerol reverses mechanical allodynia through α2A‐adrenergic modulation of thalamocortical signaling in chemotherapy‐induced neuropathy

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Chemotherapy‐induced peripheral neuropathy (CIPN) is a prevalent and treatment‐resistant side effect of platinum‐based chemotherapy, characterised by mechanical allodynia. Cannabigerol (CBG), a non‐psychoactive cannabinoid, has shown antinociceptive potential, but its site and mechanism of action remain unclear.
Quinn W. Wade, Nathan Morris, Diana E. Sepulveda, Alonso Cortez‐Resendiz, Christopher Brandl, Jennifer E. Lausch, Mariya Starostina, Nicholas M. Graziane   +7 more
wiley   +1 more source

Reply to a letter from Miesbach and Srivastava: response to hemophilia B gene therapy based on adeno-associated virus serotype 5 antibody status. [PDF]

Res Pract Thromb Haemost
Klamroth R, Monahan PE, Le Quellec S.
europepmc   +1 more source

CKLF‐like MARVEL transmembrane domain‐containing superfamily 8 (CMTM8) promotes Notch signalling to maintain CD8+ T cell‐ and NK cell‐dependent tumour immune escape

British Journal of Pharmacology, EarlyView.
Background and Purpose The CKLF‐like MARVEL transmembrane domain containing superfamily (CMTM) has an important role in tumour immunity. The role of CMTM8 in tumour immune microenvironment (TIME) remains unknown. The aim was to investigate the relationship between CMTM8 and antitumour immunity. Experimental Approach Lentiviral system was established to
Fanglin Li, Longhua Gu, Runqiu Chen, Zhiying Li, Rong Zhang, Chen Chen, Yi Liu, Xinhang Zheng, Yiting Wang, Shanna Wu, Jianhua Sun, Jing Chen, Bingshun Wang, Likun Gong, Yiru Long   +14 more
wiley   +1 more source

Adeno-Associated Virus-Based Gene Therapy for Lafora Disease in <i>Epm2b</i>-Deficient Mice. [PDF]

Int J Mol Sci
Zafra-Puerta L, Iglesias-Cabeza N, Sanz P, García-Gimeno MA, Sánchez-Martín G, Sánchez MP, Serratosa JM.   +6 more
europepmc   +1 more source

Contaminating plasmid sequences and disrupted vector genomes in the liver following adeno-associated virus gene therapy. [PDF]

Nat Med
Buddle S, Brown LK, Morfopoulou S, Torres Montaguth OE, Scoto M, Herder V, Dhawan A, Brown JR, Atkinson L, Kopec A, Davis D, Storey N, Campos L, Sebire N, Macpherson H, Lee J, Orton R, Baranello G, Asamaphan P, Ilia G, Karda R, Belfield H, ISARIC4C Investigators, Counsell J, Waddington SN, Thomson EC, Muntoni F, Breuer J.   +27 more
europepmc   +1 more source

Insights into Adeno-Associated Virus Capsid Charge Heterogeneity. [PDF]

Anal Chem
Wu J, Draper BE, Jarrold MF, Heger CD.
europepmc   +1 more source

Hypoxia Exacerbates Periapical Periodontitis‐Associated Pathological Bone Loss via the Hypoxia‐Inducible Factor‐2α‐Calmodulin‐Dependent Protein Kinase IV Axis

Cell Proliferation, EarlyView.
Hypoxia exposure activates HIF‐2α, which binds to the Camk4 promoter to enhance RANKL‐mediated osteoclast differentiation, leading to aggravated alveolar bone resorption in periapical periodontitis. ABSTRACT Periapical periodontitis is one of the most common inflammatory bone destructive diseases. Epidemiological evidence suggests that hypoxia exposure,
Kang Gao, Yifan Xu, Haoran Du, Zixiao Li, Xiaochen Fang, Minghui Wang, Jia Liu, Xu Zha, Xianglong Han, Weihua Guo, Xicheng Liu, Jian Zhou   +11 more
wiley   +1 more source

Tropism and Retinal Transduction Efficiency of Adeno-Associated Virus Serotypes in Mice. [PDF]

Invest Ophthalmol Vis Sci
Wu W, McRae J, Brown A, Agbaga MP.
europepmc   +1 more source