Results 241 to 250 of about 110,545 (302)

Role of the UHRF1–KLHL6–CORO2B axis in obesity‐related insulin resistance

open access: yesJournal of Diabetes Investigation, EarlyView.
In high‐fat diet (HFD)‐induced obese mice with insulin resistance, overexpression of UHRF1 may recruit DNMT1 to promote DNA methylation of KLHL6, leading to its downregulation. Subsequently, suppression of KLHL6 may decrease the ubiquitination of CORO2B, resulting in elevated CORO2B protein levels.
Xu Deng   +5 more
wiley   +1 more source

Adeno-associated virus-miR-128-3p sponge regulates breast muscle growth and intramuscular fat content in chickens. [PDF]

open access: yesFood Chem (Oxf)
Zhu T   +15 more
europepmc   +1 more source

Recombinant Adeno-associated Virus Vectors

open access: yesJapanese Journal of Thrombosis and Hemostasis, 1998
openaire   +2 more sources

Techniques for subretinal injections in animals

open access: yesVeterinary Ophthalmology, Volume 28, Issue 2, Page 506-518, March 2025.
Abstract Subretinal injections are not commonly performed during clinical treatment of animals but are frequently used in laboratory animal models to assess therapeutic efficacy and safety of gene and cell therapy products. Veterinary ophthalmologists are often employed to perform the injections in the laboratory animal setting, due to knowledge of ...
Ryan F. Boyd, Simon M. Petersen‐Jones
wiley   +1 more source

Neuroprotective roles of klotho: Molecular pathways and therapeutic implications for cognitive health in neurological and psychiatric diseases

open access: yesExperimental Physiology, EarlyView.
Abstract Klotho, a pleiotropic protein initially identified for its role in kidney function, has garnered significant attention for its neuroprotective properties in various neurodegenerative diseases. It regulates key processes, such as oxidative stress, neuroinflammation, synaptic plasticity and myelination, all crucial for maintaining neuronal ...
Amir Arsalan Ghahari   +7 more
wiley   +1 more source

Impact of multiplicity of infection and baculovirus co-infection ratio on recombinant adeno-associated virus vector production in insect cells. [PDF]

open access: yesFront Bioeng Biotechnol
Schrama M   +8 more
europepmc   +1 more source

Development and implementation of an LC-MS-based multi-attribute method for adeno-associated virus. [PDF]

open access: yesMol Ther Methods Clin Dev
Powers TW   +5 more
europepmc   +1 more source

Chinese guidance for the clinical application of adeno-associated virus vector-based gene therapy for hemophilia B (2025). [PDF]

open access: yesBlood Sci
Xue F   +25 more
europepmc   +1 more source

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