Results 261 to 270 of about 110,545 (302)
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Human Gene Therapy, 2009
Recombinant adeno-associated virus (rAAV) holds promise for applications in gene therapy. Advances in clinical studies of rAAV-based gene therapeutics have generated an encouraging momentum in the field of gene therapy; however, one of the major obstacles to the eventual clinical success of rAAV-mediated gene therapy is the need for large-scale ...
Hongwei, Zhang +4 more
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Recombinant adeno-associated virus (rAAV) holds promise for applications in gene therapy. Advances in clinical studies of rAAV-based gene therapeutics have generated an encouraging momentum in the field of gene therapy; however, one of the major obstacles to the eventual clinical success of rAAV-mediated gene therapy is the need for large-scale ...
Hongwei, Zhang +4 more
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Hematology/Oncology Clinics of North America, 2022
Although the number of market-approved gene therapies is still low, this new class of therapeutics has become an integral part of modern medicine. The success and safety of gene therapy depend on the vectors used to deliver the therapeutic material. Adeno-associated virus (AAV) vectors have emerged as the most frequently used delivery system for in ...
Nico, Jäschke, Hildegard, Büning
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Although the number of market-approved gene therapies is still low, this new class of therapeutics has become an integral part of modern medicine. The success and safety of gene therapy depend on the vectors used to deliver the therapeutic material. Adeno-associated virus (AAV) vectors have emerged as the most frequently used delivery system for in ...
Nico, Jäschke, Hildegard, Büning
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Biology of Adeno-associated Virus
1996Adeno-associated Virus (AAV) is classified as a member of the family Parvoviridae (Siegl et al. 1985; Berns 1990a). Members are small, nonenveloped, icosahedral viruses (diameter ca. 20–26 nm) with linear, single-stranded DNA genomes of 4.7–6 kb. Parvoviridae have been isolated from many species ranging from insects to humans.
K I, Berns, C, Giraud
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Adenovirus and Adeno-Associated Virus Vectors
DNA and Cell Biology, 2002Recombinant adenovirus (rAd) and recombinant adeno-associated virus (rAAV) are among the most extensively used vectors in gene therapy studies to date. These two vectors share some similar features such as a broad host range and ability to infect both proliferating and quiescent cells.
Chooi May, Lai +2 more
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Processing of adeno-associated virus RNA
Frontiers in Bioscience, 2008Adeno-associated viruses (AAVs), members of the Dependovirus genus of the subfamily Parvovirinae, family Parvoviridae, have single-stranded DNA genomes that replicate via a double-stranded DNA intermediate which serves as the transcription template. They exhibit a highly compact, overlapping genetic organization which is surprisingly variable amongst ...
Jianming, Qiu, David, Pintel
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1984
Adeno-associated virus (AAV) was discovered as a contaminant of purified adenovirus preparations. Although the small icosahedral particles (diameter 18–28 nm) were initially considered to be either precursors to the mature adenovirus particle or breakdown products of the virion, they were rapidly demonstrated to represent a distinct virus that was ...
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Adeno-associated virus (AAV) was discovered as a contaminant of purified adenovirus preparations. Although the small icosahedral particles (diameter 18–28 nm) were initially considered to be either precursors to the mature adenovirus particle or breakdown products of the virion, they were rapidly demonstrated to represent a distinct virus that was ...
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The Genetics of Adeno-Associated Virus
1984Adeno-associated virus (AAV) is a defective parvovirus which is absolutely dependent on coinfection with a helper virus for a productive lytic cycle (for a review, see ref. 1). Either adenoviruses or herpes viruses can act as helpers (2–5) . In the absence of a helper virus, AAV efficiently integrates into host cell chromosomes via its inverted ...
N, Muzyczka +4 more
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Multimodal Production of Adeno-Associated Virus
2019Adeno-associated virus (AAV) is an increasingly popular tool in the research laboratory, and use of this viral vector clinically is occurring at an accelerated pace. Nevertheless, despite its popularity, AAV is a relatively cumbersome virus to produce; however, significant efforts have been invested to develop, optimize, and simplify methodology that ...
Ivette M, Sandoval +2 more
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Generation of Recombinant Adeno-Associated Virus
2003Adeno-associated virus (AAV) was discovered about 30 yr ago as a contaminant of adenovirus preparations. Since its discovery, researchers have described many unique characteristics of AAV biology that have made it attractive as a potential vector for gene therapy.
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Recombinant adeno-associated virus vectors.
IDrugs : the investigational drugs journal, 2011Recombinant adeno-associated virus (rAAV) is a promising vector for somatic gene therapy due to the ability to transduce terminally-differentiated and non-dividing cells, the lack of any apparent pathogenicity, a low immunogenicity, a relatively high stability of transgene expression, and the potential for targeted integration. Improved methods of rAAV
M, Hallek +5 more
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