Results 291 to 300 of about 115,653 (351)

PHGDH Orchestrates Cell Cycle Progression to Drive Cardiomyocyte Proliferation and Myocardial Regeneration via TGF‐β/Smad Signalling Pathway

Cell Proliferation, EarlyView.
PHGDH promoted cardiomyocyte proliferation and myocardial regeneration via cell cycle and TGF‐β/Smad signalling pathways during cardiac repair. Moreover, PHGDH benefits cardiac repair and cardiomyocyte proliferation in mammalian mice following MI. ABSTRACT The mature mammalian heart has limited ability for self‐repair and regeneration.
Han Zhang, Li Zhang, Zehao Feng, Xing Li, Zhaohui Qiu, Xingyun Wang, Lingmei Qian   +6 more
wiley   +1 more source

Overexpression of interleukin-4 using adeno-associated virus is a potential strategy to enhance bone regeneration. [PDF]

JBMR Plus
Kim H, Kim KH, Kang L, Seol YJ, Chung SH, Park SY.   +5 more
europepmc   +1 more source

Identification and Phylogenetic Characterisation of Novel Adeno‐Associated Virus Capsids in Non‐Human Primate Tissues

Cell Proliferation, EarlyView.
AAV's widespread application is currently confronting critical challenges. This study established a systematic framework of ‘natural discovery–evolutionary analysis–functional optimization’, providing a new paradigm for the development of next‐generation AAV vectors with clinical‐grade tissue specificity, low immunogenicity, and cross‐species ...
Liyu Zhu, Kai Xu, Yali Ding, Kailun Liu, Jing Liu, Zongren Hou, Rui Niu, Ning Yang, Hualing Qin, Baoyang Hu, Ying Zhang, Wei Li   +11 more
wiley   +1 more source

Pulmonary Vascular Endothelial Cells in Lung Diseases: Mechanisms, Therapeutic Strategies, and Future Directions

Cell Proliferation, EarlyView.
The pathogenic mechanisms of pulmonary vascular endothelial cells (VECs) in lung diseases and their multimodal therapeutic strategies. ABSTRACT Pulmonary vascular endothelial cells (VECs) are essential for the normal function of the lung, through maintaining vascular barrier integrity, regulating blood flow, and participating in inflammatory responses ...
Qianyue Liu, Hongshuai Zheng, Jing Liu, Ming Gao, Faquan Lin, Lin Liao   +5 more
wiley   +1 more source

Hypoxia Exacerbates Periapical Periodontitis‐Associated Pathological Bone Loss via the Hypoxia‐Inducible Factor‐2α‐Calmodulin‐Dependent Protein Kinase IV Axis

Cell Proliferation, EarlyView.
Hypoxia exposure activates HIF‐2α, which binds to the Camk4 promoter to enhance RANKL‐mediated osteoclast differentiation, leading to aggravated alveolar bone resorption in periapical periodontitis. ABSTRACT Periapical periodontitis is one of the most common inflammatory bone destructive diseases. Epidemiological evidence suggests that hypoxia exposure,
Kang Gao, Yifan Xu, Haoran Du, Zixiao Li, Xiaochen Fang, Minghui Wang, Jia Liu, Xu Zha, Xianglong Han, Weihua Guo, Xicheng Liu, Jian Zhou   +11 more
wiley   +1 more source

Real-time genome imaging of host interactions in adeno-associated virus genome release. [PDF]

iScience
Bustamante-Jaramillo LF, Yue L, Fingal J, Rydell G, Johansson M, Edreira T, Müller OJ, Hille S, Müller M, Gallardo F, Chen Q, Blondot ML, Kann M.   +12 more
europepmc   +1 more source

The Role of SAMHD1 in Viral Resistance and Transduction Efficiency Challenges in Pediatric Hematological Malignancies: Mechanistic Insights and Clinical Perspectives

European Journal of Haematology, EarlyView.
SAMHD1 regulates intracellular dNTP pools, influencing lentiviral transduction, gene therapy efficiency, and disease progression in pediatric hematological malignancies. Integrated bioinformatics and targeted strategies, including CRISPR and pharmacological inhibition, highlight its therapeutic potential.
Waseem Alzamzami
wiley   +1 more source

Adeno-Associated Virus 2 (AAV2) - Induced RPA exhaustion generates cellular DNA damage and restricts viral gene expression. [PDF]

PLoS Pathog
Summers MF, Haubold MK, Morgenstern M, Shepherd P, Larsen CIS, Bartz AE, Thirumoorthy G, Kirchdoerfer RN, Coon JJ, Mehta KPM, Majumder K.   +10 more
europepmc   +1 more source

Advancing adeno-associated virus for Duchenne muscular dystrophy treatment: Moving beyond rodent models. [PDF]

Mol Ther Methods Clin Dev
Ikotun OF, McNally EM, Spencer MJ.
europepmc   +1 more source

A synthetic platform for developing recombinant adeno-associated virus type 8 producer cell lines. [PDF]

Biotechnol Prog
Lin YC, Kuo HJ, Lu M, Mahl T, Aslanidi G, Hu WS.   +5 more
europepmc   +1 more source