Results 111 to 120 of about 1,187,996 (336)

EGFR Mutation Detection in Whole Slide Images of Non‐Small Cell Lung Cancers Using a Two‐Stage Deep Transfer Learning Approach

Cancer Medicine
Background Lung cancer (LC) is the leading cause of cancer death worldwide. Non‐small cell lung cancer is the most frequent and includes adenocarcinoma and squamous cell carcinoma. Currently, LC treatment is based on tumor molecular profiling.
Michele Zanoletti, Filippo Ugolini, Laila El Bachiri, Valeria Pasini, Marco Laurino, Francesco De Logu, Eleonora Melissa, Carolina Marchi, Maria Colombino, Daniela Massi, Guido Rindi, Camilla Eva Comin, Giuseppe Palmieri, Antonio Cossu   +13 more
doaj   +1 more source

Widespread parainflammation in human cancer. [PDF]

, 2016
BackgroundChronic inflammation has been recognized as one of the hallmarks of cancer. We recently showed that parainflammation, a unique variant of inflammation between homeostasis and chronic inflammation, strongly promotes mouse gut tumorigenesis upon ...
Aran, Dvir, Ben-Neriah, Yinon, Biton, Moshe, Butte, Atul J, Hellman, Asaf, Lasry, Audrey, Pikarsky, Eli, Zinger, Adar   +7 more
core   +3 more sources

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Malignant Transformation in Tailgut Cyst Presenting as Retrorectal Adenosquamous Carcinoma: A Case Report [PDF]

Journal of Clinical and Diagnostic Research
Tailgut cysts are rare congenital retrorectal lesions that can rarely undergo malignant transformation. Occurring predominantly in middle-aged females, these lesions are mostly asymptomatic, with rare symptoms arising mostly in association with ...
Dipkana Das, Raya Banerjee, Durgaprasad Nanda, Namrata Maity   +3 more
doaj   +1 more source

Analysis of the Clinicopathologic Characteristics of Lung Adenocarcinoma With CTNNB1 Mutation

Frontiers in Genetics, 2020
IntroductionLung adenocarcinoma with CTNNB1 mutation is relatively uncommon, and its clinicopathologic characteristics, disease course, and prognosis have not been well-studied.MethodsA total of 564 lung adenocarcinoma patients were enrolled in this ...
Chao Zhou, Chao Zhou, Wentao Li, Jinchen Shao, Jikai Zhao, Chang Chen   +5 more
doaj   +1 more source

FGFR1 Cooperates with EGFR in Lung Cancer Oncogenesis, and Their Combined Inhibition Shows Improved Efficacy [PDF]

, 2019
Introduction: There is substantial evidence for the onco- genic effects of fi broblast growth factor receptor 1 (FGFR1) in many types of cancer, including lung cancer, but the role of this receptor has not been addressed speci fi cally in lung ...
Carnero Moya, Amancio, Cirauqui, Cristina, Conde, Esther, Enguita, Ana Belén, Ferrer, Irene, Marrugal, Ángela, Molina Pinelo, Sonia, Ojeda Márquez, Laura, Paz Ares, Luis, Ponce Aix, Santiago, Quintanal Villalonga, Álvaro Diego, Suárez, Rocío   +11 more
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Mutated TP53 is a marker of increased VEGF expression: analysis of 7,525 pan-cancer tissues. [PDF]

, 2020
Anti-angiogenic therapies are an important class of anti-cancer treatment drugs. However, their efficacy is limited to certain tumors and would benefit from identifying a biomarker predictive of therapeutic response.
Boichard, Amélie, Kurzrock, Razelle, Li, Alex M   +2 more
core  

Dual EGFR inhibition in combination with anti-VEGF treatment: a phase I clinical trial in non-small cell lung cancer. [PDF]

, 2013
BackgroundPreclinical data indicate EGFR signals through both kinase-dependent and independent pathways and that combining a small-molecule EGFR inhibitor, EGFR antibody, and/or anti-angiogenic agent is synergistic in animal models.MethodsWe conducted a ...
Bastida, Christel, Falchook, Gerald S, Fu, Siqing, Hong, David S, Jiang, Yunfang, Kurzrock, Razelle, Morgan-Linnell, Sonia K, Naing, Aung, Piha-Paul, Sarina A, Tsimberidou, Apostolia M, Wheler, Jennifer J, Zinner, Ralph   +11 more
core   +2 more sources

Mapping the hallmarks of lung adenocarcinoma with massively parallel sequencing.

Cell, 2012
Lung adenocarcinoma, the most common subtype of non-small cell lung cancer, is responsible for more than 500,000 deaths per year worldwide. Here, we report exome and genome sequences of 183 lung adenocarcinoma tumor/normal DNA pairs.
M. Imieliński, A. Berger, P. Hammerman, Bryan Hernandez, Trevor J Pugh, Eran Hodis, Jeonghee Cho, J. Suh, M. Capelletti, A. Sivachenko, C. Sougnez, D. Auclair, M. Lawrence, P. Stojanov, K. Cibulskis, Kyusam Choi, L. D. Waal, Tanaz Sharifnia, Angela N. Brooks, H. Greulich, S. Banerji, T. Zander, D. Seidel, F. Leenders, S. Ansén, C. Ludwig, W. Engel‐Riedel, E. Stoelben, J. Wolf, C. Goparju, K. Thompson, W. Winckler, D. Kwiatkowski, B. Johnson, P. Jänne, V. Miller, W. Pao, W. Travis, H. Pass, S. Gabriel, E. Lander, Roman K. Thomas, L. Garraway, G. Getz, M. Meyerson   +44 more
semanticscholar   +1 more source