Results 11 to 20 of about 426,766 (100)

Zolbetuximab plus CAPOX in CLDN18.2-positive gastric or gastroesophageal junction adenocarcinoma: the randomized, phase 3 GLOW trial

open access: yesNature Network Boston, 2023
In the randomized, double-blind, phase 3 GLOW trial, capecitabine and oxaliplatin combined with zolbetuximab, a monoclonal antibody that targets CLDN18.2, significantly improved progression-free survival and overall survival in patients with CLDN18.2 ...
Manish A. Shah   +20 more
semanticscholar   +1 more source

Lung adenocarcinoma promotion by air pollutants

open access: yesNature, 2023
A complete understanding of how exposure to environmental substances promotes cancer formation is lacking. More than 70 years ago, tumorigenesis was proposed to occur in a two-step process: an initiating step that induces mutations in healthy cells ...
William Hill   +326 more
semanticscholar   +1 more source

Pancreatic Adenocarcinoma, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology.

open access: yesThe Journal of the National Comprehensive Cancer Network, 2021
Pancreatic cancer is the fourth leading cause of cancer-related death among men and women in the United States. A major challenge in treatment remains patients' advanced disease at diagnosis.
M. Tempero   +35 more
semanticscholar   +1 more source

Single-cell RNA sequencing demonstrates the molecular and cellular reprogramming of metastatic lung adenocarcinoma

open access: yesNature Communications, 2020
Advanced metastatic cancer poses utmost clinical challenges and may present molecular and cellular features distinct from an early-stage cancer. Herein, we present single-cell transcriptome profiling of metastatic lung adenocarcinoma, the most prevalent ...
N. Kim   +20 more
semanticscholar   +1 more source

Comprehensive molecular profiling of lung adenocarcinoma

open access: yesNature, 2014
Adenocarcinoma of the lung is the leading cause of cancer death worldwide. Here we report molecular profiling of 230 resected lung adenocarcinomas using messenger RNA, microRNA and DNA sequencing integrated with copy number, methylation and proteomic ...
Eric A. Joshua D. Angela N. Alice H. William Juliann Da Collisson Campbell Brooks Berger Lee Chmielecki Be   +356 more
semanticscholar   +1 more source

Comprehensive molecular characterization of gastric adenocarcinoma

open access: yesNature, 2014
Gastric cancer is a leading cause of cancer deaths, but analysis of its molecular and clinical characteristics has been complicated by histological and aetiological heterogeneity.
A. Bass   +259 more
semanticscholar   +1 more source

International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society International Multidisciplinary Classification of Lung Adenocarcinoma

open access: yesJournal of Thoracic Oncology, 2011
Introduction: Adenocarcinoma is the most common histologic type of lung cancer. To address advances in oncology, molecular biology, pathology, radiology, and surgery of lung adenocarcinoma, an international multidisciplinary classification was sponsored ...
W. Travis   +47 more
semanticscholar   +1 more source

Phase III study of afatinib or cisplatin plus pemetrexed in patients with metastatic lung adenocarcinoma with EGFR mutations.

open access: yesJournal of Clinical Oncology, 2013
PURPOSE The LUX-Lung 3 study investigated the efficacy of chemotherapy compared with afatinib, a selective, orally bioavailable ErbB family blocker that irreversibly blocks signaling from epidermal growth factor receptor (EGFR/ErbB1), human epidermal ...
L. Sequist   +19 more
semanticscholar   +1 more source

Pathologist-level classification of histologic patterns on resected lung adenocarcinoma slides with deep neural networks [PDF]

open access: yesScientific Reports, 2019
Classification of histologic patterns in lung adenocarcinoma is critical for determining tumor grade and treatment for patients. However, this task is often challenging due to the heterogeneous nature of lung adenocarcinoma and the subjective criteria ...
Jason Wei   +5 more
semanticscholar   +1 more source

Virtual microdissection identifies distinct tumor- and stroma-specific subtypes of pancreatic ductal adenocarcinoma

open access: yesNature Genetics, 2015
Pancreatic ductal adenocarcinoma (PDAC) remains a lethal disease with a 5-year survival rate of 4%. A key hallmark of PDAC is extensive stromal involvement, which makes capturing precise tumor-specific molecular information difficult.
Richard A. Moffitt   +17 more
semanticscholar   +1 more source

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