Results 11 to 20 of about 1,187,996 (336)
First-line nivolumab plus chemotherapy versus chemotherapy alone for advanced gastric, gastro-oesophageal junction, and oesophageal adenocarcinoma (CheckMate 649): a randomised, open-label, phase 3 trial.
The Lancet, 2021 BACKGROUND
First-line chemotherapy for advanced or metastatic human epidermal growth factor receptor 2 (HER2)-negative gastric or gastro-oesophageal junction adenocarcinoma has a median overall survival (OS) of less than 1 year.Y. Janjigian, K. Shitara, M. Moehler, M. Garrido, P. Salman, L. Shen, L. Wyrwicz, K. Yamaguchi, T. Skoczylas, Arinilda Silva Campos Bragagnoli, Tianshu Liu, M. Schenker, P. Yánez, M. Tehfé, R. Kowalyszyn, M. Karamouzis, R. Brugés, T. Zander, R. Pazo-Cid, E. Hitre, K. Feeney, J. Cleary, V. Poulart, D. Cullen, M. Lei, H. Xiao, K. Kondo, Mingshun Li, J. Ajani +28 moresemanticscholar +1 more sourceZolbetuximab plus CAPOX in CLDN18.2-positive gastric or gastroesophageal junction adenocarcinoma: the randomized, phase 3 GLOW trial
Nature Medicine, 2023 In the randomized, double-blind, phase 3 GLOW trial, capecitabine and oxaliplatin combined with zolbetuximab, a monoclonal antibody that targets CLDN18.2, significantly improved progression-free survival and overall survival in patients with CLDN18.2 ...M. Shah, K. Shitara, J. Ajani, Y. Bang, P. Enzinger, D. Ilson, F. Lordick, E. Van Cutsem, J. Gallego Plazas, Jing Huang, L. Shen, S. Oh, P. Sunpaweravong, Hwoei Fen Soo Hoo, H. Turk, Mok Oh, J. Park, Diarmuid Moran, Pranob P. Bhattacharya, A. Arozullah, Ruifeng Xu +20 moresemanticscholar +1 more sourceLung adenocarcinoma promotion by air pollutants
Nature, 2023 A complete understanding of how exposure to environmental substances promotes cancer formation is lacking. More than 70 years ago, tumorigenesis was proposed to occur in a two-step process: an initiating step that induces mutations in healthy cells ...William Hill, Emilia L. Lim, C. Weeden, Claudia Lee, M. Augustine, Kezhong Chen, F. Kuan, F. Marongiu, E. J. Evans, D. Moore, F. S. Rodrigues, O. Pich, B. Bakker, H. Cha, R. Myers, F. van Maldegem, J. Boumelha, S. Veeriah, A. Rowan, C. Naceur-Lombardelli, T. Karasaki, Monica Sivakumar, Swapnanil De, D. Caswell, Ai Nagano, James R. M. Black, Carlos Martínez-Ruiz, M. Ryu, Ryan D. Huff, Shijian Li, M. Favé, Alastair Magness, A. Suárez‐Bonnet, S. Priestnall, M. Lüchtenborg, K. Lavelle, Joanna Pethick, Steven I Hardy, F. McRonald, Meng-Hung Lin, Clara I. Troccoli, Moumita Ghosh, Y. Miller, D. Merrick, R. Keith, M. Al Bakir, Chris Bailey, M. Hill, L. Saal, Yilun Chen, A. George, C. Abbosh, N. Kanu, Se-Hoon Lee, N. Mcgranahan, C. Berg, P. Sasieni, R. Houlston, C. Turnbull, Stephen Lam, P. Awadalla, E. Grönroos, J. Downward, T. Jacks, C. Carlsten, I. Malanchi, A. Hackshaw, K. Litchfield, Jason F. Amrita Apostolos Azmina Keng Mohamad Mohammed F Lester Bajaj Nakas Sodha-Ramdeen Ang Tufail Chowdh, Jason Lester, A. Bajaj, A. Nakas, Azmina Sodha-Ramdeen, K. Ang, M. Tufail, M. F. Chowdhry, M. Scotland, R. Boyles, S. Rathinam, Claire Wilson, Domenic Marrone, S. Dulloo, D. Fennell, Gurdeep Matharu, J. Shaw, Joan Riley, L. Primrose, E. Boleti, Heather Cheyne, Mohammed Khalil, S. Richardson, Tracey Cruickshank, Gillian Price, K. Kerr, S. Benafif, Kayleigh Gilbert, B. Naidu, Akshay J. Patel, A. Osman, Christer Lacson, G. Langman, Helen Shackleford, M. Djearaman, S. Kadiri, Gary Middleton, Angela E. Leek, Jack Davies Hodgkinson, Nicola Totten, A. Montero, E. Smith, E. Fontaine, F. Granato, H. Doran, Juliette Novasio, K. Rammohan, L. Joseph, P. Bishop, R. Shah, Stuart Moss, Vijay Joshi, P. Crosbie, F. Gomes, Kate Brown, M. Carter, A. Chaturvedi, L. Priest, P. Oliveira, C. Lindsay, F. Blackhall, M. Krebs, Y. Summers, A. Clipson, J. Tugwood, Alastair Kerr, D. Rothwell, E. Kilgour, C. Dive, H. Aerts, R. Schwarz, Tom L. Kaufmann, G. Wilson, R. Rosenthal, P. van Loo, Nicolai J. Birkbak, Z. Szallasi, Judit Kisistók, M. Sokač, Roberto Salgado, M. Dióssy, J. Demeulemeester, Abigail Bunkum, A. Stewart, A. Frankell, Angeliki Karamani, A. Toncheva, A. Huebner, B. Chain, B. Campbell, Carla Castignani, C. Puttick, Corentin Richard, C. Hiley, D. Pearce, D. Karagianni, D. Biswas, D. Levi, Elena Hoxha, E. L. Cadieux, E. Colliver, E. Nye, F. Gálvez-Cancino, Foteini Athanasopoulou, F. Gimeno-Valiente, G. Kassiotis, Georgia Stavrou, Gerasimos Mastrokalos, Haoran Zhai, H. Lowe, Ignacio Matos, J. Goldman, J. Reading, Javier Herrero, J. Rane, J. Nicod, J. Lam, J. Hartley, K. Peggs, Katey S. S. Enfield, Kayalvizhi Selvaraju, K. Thol, K. Ng, K. Dijkstra, Kristiana Grigoriadis, Krupa J Thakkar, L. Ensell, Mansi Shah, Mar Durán, Maria Litovchenko, M. W. Sunderland, M. Dietzen, Michelle M. Leung, M. Escudero, Mihaela Angelova, M. Tanić, O. Chervova, Olivia Lucas, Othman Al-Sawaf, Paulina Prymas, P. Hobson, Piotr Pawlik, R. Stone, R. Bentham, R. Hynds, R. Vendramin, S. Saghafinia, Saioa López, Samuel Gamble, S. Ung, S. Quezada, Sharon P. Vanloo, Simone Zaccaria, S. Hessey, S. Ward, S. Boeing, Stephan Beck, S. Bola, Tamara Denner, T. Marafioti, Thanos P. Mourikis, T. Watkins, V. Spanswick, Vittorio Barbè, Wei-Ting Lu, Wing-Kin Liu, Yin Wu, Yutaka Naito, Zoe Ramsden, C. Veiga, G. Royle, C. Collins-Fekete, F. Fraioli, P. Ashford, T. Clark, Martin D. Forster, Siow-Ming Lee, E. Borg, M. Falzon, D. Papadatos-Pastos, James Wilson, T. Ahmad, A. Procter, Asia Ahmed, Magali N. Taylor, A. Nair, David S. Lawrence, D. Patrini, N. Navani, R. Thakrar, S. Janes, E. M. Hoogenboom, Fleur Monk, James W. Holding, Junaid Choudhary, Kunal Bhakhri, M. Scarci, M. Hayward, N. Panagiotopoulos, Pat Gorman, R. Khiroya, R. Stephens, Y. Wong, S. Bandula, A. Sharp, Sean Smith, N. Gower, H. Dhanda, Kitty Chan, Camilla Pilotti, R. Leslie, Anca-Ioana Grapa, Hanyun Zhang, K. AbdulJabbar, Xiaoxi Pan, Yinyin Yuan, David Chuter, M. Mackenzie, S. Chee, A. Alzetani, J. Cave, Lydia Scarlett, J. Richards, Papawadee Ingram, S. Austin, Eric Lim, P. De Sousa, S. Jordan, A. Rice, H. Raubenheimer, H. Bhayani, L. Ambrose, A. Devaraj, Hema Chavan, S. Begum, S. Buderi, Daniel Kaniu, Mpho Malima, S. Booth, A. Nicholson, Nádia Fernandes, P. Shah, C. Proli, M. Hewish, S. Danson, M. Shackcloth, Lily Robinson, P. Russell, K. Blyth, C. Dick, J. Le Quesne, A. Kirk, M. Asif, R. Bilancia, N. Kostoulas, Mathew Thomas, J. DeGregori, M. Jamal-Hanjani, C. Swanton +326 moresemanticscholar +1 more sourcePancreatic Adenocarcinoma, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology.
The Journal of the National Comprehensive Cancer Network, 2021 Pancreatic cancer is the fourth leading cause of cancer-related death among men and women in the United States. A major challenge in treatment remains patients' advanced disease at diagnosis.M. Tempero, M. Malafa, M. Al-Hawary, S. Behrman, A. Benson, D. Cardin, E. Chiorean, V. Chung, B. Czito, M. Del Chiaro, M. Dillhoff, T. Donahue, E. Dotan, C. Ferrone, C. Fountzilas, J. Hardacre, W. Hawkins, Kelsey A Klute, A. Ko, J. Kunstman, N. Loconte, A. Lowy, C. Moravek, E. Nakakura, A. Narang, Jorge V. Obando, Patricio M. Polanco, S. Reddy, M. Reyngold, C. Scaife, Jeanne Shen, C. Vollmer, R. Wolff, B. Wolpin, B. Lynn, Giby V. George +35 moresemanticscholar +1 more sourceProteogenomic characterization of pancreatic ductal adenocarcinoma.
Cell, 2021 Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer with poor patient survival. Toward understanding the underlying molecular alterations that drive PDAC oncogenesis, we conducted comprehensive proteogenomic analysis of 140 pancreatic ...L. Cao, Chen Huang, D. Zhou, Yingwei Hu, T. Lih, Sara R. Savage, Karsten Krug, D. Clark, M. Schnaubelt, Lijun Chen, F. Leprevost, R. V. Eguez, Weiming Yang, Jianbo Pan, Bo Wen, Yongchao Dou, Wen Jiang, Yuxing Liao, Zhiao Shi, N. Terekhanova, Song Cao, Rita Jui-Hsien Lu, Yize Li, Ruiyang Liu, Houxiang Zhu, Peter Ronning, Yige Wu, Matthew A. Wyczalkowski, H. Easwaran, Ludmila V. Danilova, A. Mer, S. Yoo, Joshua M Wang, Wenke Liu, B. Haibe-Kains, M. Thiagarajan, S. Jewell, G. Hostetter, Chelsea J. Newton, Q. K. Li, M. Roehrl, D. Fenyö, Pei Wang, A. Nesvizhskii, D. Mani, G. Omenn, Emily Boja, M. Mesri, A. Robles, H. Rodriguez, O. Bathe, D. Chan, R. Hruban, L. Ding, Bing Zhang, Hui Zhang, Mitual B. Amin, E. An, Christine Ayad, Thomas Bauer, Chet Birger, M. Birrer, S. Boca, William Bocik, M. Borucki, S. Cai, Steve Carr, Sandra R. Cerda, Huan Chen, Steven F. Chen, D. Chesla, A. Chinnaiyan, A. Colaprico, S. Cottingham, Magdalena Derejska, S. Dhanasekaran, M. Domagalski, B. Druker, Elizabeth Duffy, Maureen A. Dyer, Nathan J. Edwards, M. Ellis, J. Eschbacher, Alicia Francis, Jesse Francis, S. Gabriel, N. Gabrovski, J. Gardner, G. Getz, Michael A. Gillette, C. A. Goldthwaite, Pamela Grady, Shuai Guo, P. Hariharan, Tara Hiltke, B. Hindenach, K. Hoadley, Jasmine Huang, Corbin D. Jones, K. Ketchum, C. Kinsinger, J. Koziak, K. Kuśnierz, Tao Liu, J. Long, D. Mallery, S. Mareedu, R. Matteotti, Nicollette Maunganidze, P. McGarvey, P. Minoo, O. Paklina, A. Paulovich, S. Payne, O. Potapova, B. Pruetz, L. Qi, Nancy V. Roche, K. Rodland, D. Rohrer, E. Schadt, A. Shabunin, T. Shelton, Y. Shutack, Shilpi Singh, Michael V. Smith, Richard D. Smith, L. Sokoll, J. Suh, Ratna R. Thangudu, S. Tsang, K. S. Um, Dana R. Valley, Negin Vatanian, Wenyi Wang, G. Wilson, M. Wiznerowicz, Zhen Zhang, Grace Zhao +138 moresemanticscholar +1 more sourceMultiple Omics Analysis of the Role of RBM10 Gene Instability in Immune Regulation and Drug Sensitivity in Patients with Lung Adenocarcinoma (LUAD)
Biomedicines, 2023 Objective: The RNA-binding protein RBM10 can regulate apoptosis during the proliferation and migration of pancreatic cancer, endometrial cancer, and osteosarcoma cells; however, the molecular mechanism underlying lung adenocarcinoma is rarely reported ...Liusheng Wu, Qi Liu, X-J Ruan, Xinyu Luan, Yanfeng Zhong, Jixian Liu, Jun Yan, Xiaoqiang Li +7 moresemanticscholar +1 more sourceSingle-cell RNA sequencing demonstrates the molecular and cellular reprogramming of metastatic lung adenocarcinoma
Nature Communications, 2020 Advanced metastatic cancer poses utmost clinical challenges and may present molecular and cellular features distinct from an early-stage cancer. Herein, we present single-cell transcriptome profiling of metastatic lung adenocarcinoma, the most prevalent ...N. Kim, H. Kim, K. Lee, Yourae Hong, J. Cho, J. Choi, Jung-Il Lee, Y. Suh, B. Ku, Hye Hyeon Eum, Soyean Choi, Yoon-La Choi, Je-Gun Joung, W. Park, H. Jung, Jong-Mu Sun, Se-Hoon Lee, J. Ahn, Keunchil Park, M. Ahn, Hae-Ock Lee +20 moresemanticscholar +1 more sourceComprehensive molecular profiling of lung adenocarcinoma
Nature, 2014 Adenocarcinoma of the lung is the leading cause of cancer death worldwide. Here we report molecular profiling of 230 resected lung adenocarcinomas using messenger RNA, microRNA and DNA sequencing integrated with copy number, methylation and proteomic ...Eric A. Joshua D. Angela N. Alice H. William Juliann Da Collisson Campbell Brooks Berger Lee Chmielecki Be, Eric A. Joshua D. Angela N. Alice H. William Juliann Da Collisson Campbell Brooks Berger Lee Chmielecki Be, E. Collisson, Joshua D. Campbell, Angela N. Brooks, A. Berger, William Lee, J. Chmielecki, D. Beer, L. Cope, C. Creighton, Ludmila V. Danilova, L. Ding, G. Getz, P. Hammerman, D. Neil Hayes, Bryan Hernandez, J. Herman, J. Heymach, I. Jurisica, R. Kucherlapati, D. Kwiatkowski, M. Ladanyi, Gordon Robertson, N. Schultz, R. Shen, Rileen Sinha, C. Sougnez, M. Tsao, W. Travis, J. Weinstein, D. Wigle, M. Wilkerson, Andy Chu, A. Cherniack, Angela Hadjipanayis, Mara W Rosenberg, D. Weisenberger, P. 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Rabeno, Jennifer Brown, Thomas Bauer, Oleg Olga Daniil Olga Elena Konstantin V. Dolzhanskiy Potapova Rotin Voronina Nemirovich-Dan, O. Dolzhanskiy, O. Potapova, D. Rotin, Olga Voronina, Elena Nemirovich-Danchenko, K. Fedosenko, Anthony Madhusmita Suresh S. Gabriel Gal Behera Ramalingam Sica, A. Gal, M. Behera, S. Ramalingam, G. Sica, Douglas Jeff JoEllen Flieder Boyd Weaver, D. Flieder, J. Boyd, J. Weaver, Bernard Dang Kohl Huy Quoc Thinh, B. Kohl, Dang Huy Quoc Thinh, G. Sandusky, Hartmut Juhl, E. Duhig, Peter Edward James Beverly Kristen Dante Malcolm V. Illei Gabrielson Shin Lee Rodgers Trusty Brock, P. Illei, E. Gabrielson, James Shin, Beverly Lee, Kristen Rodgers, D. Trusty, M. Brock, Christina Eric Kimberly Antonia Travis Williamson Burks Rieger-Christ Holway Sullivan, C. Williamson, E. Burks, K. Rieger-Christ, A. Holway, T. Sullivan, Dennis A. Michael K. Farhad Wigle Asiedu Kosari, M. Asiedu, F. Kosari, William D. Natasha Maureen Valerie W. Travis Rekhtman Zakowski Rusch, N. Rekhtman, M. Zakowski, V. Rusch, Paul James Harvey Chandra Yvonne Zippile Suh Pass Goparaju Owusu-Sarpong, Paul Zippile, James Suh, H. Pass, C. Goparaju, Y. Owusu-Sarpong, John M. S. Sugy Jeremy Harmanjatinder Monique Bartlett Kodeeswaran Parfitt Sekhon Albert, John M. S. Bartlett, S. Kodeeswaran, J. Parfitt, H. Sekhon, Monique Albert, John Jerome B. Eckman Myers, J. Eckman, J. Myers, Richard Carl Carmelo Cheney Morrison Gaudioso, R. Cheney, Carl Morrison, Carmelo Gaudioso, Jeffrey A. Philip Mark Michael J. Borgia Bonomi Pool Liptay, J. Borgia, P. Bonomi, M. Pool, M. Liptay, Fedor Irina Moiseenko Zaytseva, F. Moiseenko, I. Zaytseva, Hendrik Michael Philipp A. Thomas R. Dienemann Meister Schnabel Muley, H. Dienemann, M. Meister, P. Schnabel, T. Muley, M. Peifer, Carmen Lynn Sophie Gomez-Fernandez Herbert Egea, C. Gomez-Fernandez, Lynn M. Herbert, Sophie C. Egea, Mei Leigh B. Lori Ashley William K. W. Huang Thorne Boice Hill Salazar Funkhouser Kimryn , Mei Huang, L. Thorne, L. Boice, Ashley Hill Salazar, W. Funkhouser, W. Kimryn Rathmell, Rajiv Samuel A. Sanja Frank Jill M. Dhir Yousem Dacic Schneider Siegfried, R. Dhir, S. Yousem, S. Dacic, F. Schneider, J. Siegfried, R. Hajek, Mark A. Sandra Bryan Watson McDonald Meyers, M. Watson, Sandra A. McDonald, B. Meyers, Belinda Ian A. Kwun M. Lindy Morgan Rayleen V. Clarke Yang Fong Hunter Windsor Bowman, B. Clarke, I. Yang, K. Fong, L. Hunter, M. Windsor, R. Bowman, Solange Igor Peters Letovanec, Solange Peters, I. Letovanec, K. Z. Khan, Mark A. Eric E. Deepak Ari B. Julien David A. Jensen Snyder Srinivasan Kahn Baboud Pot, M. Jensen, E. Snyder, D. Srinivasan, A. Kahn, J. Baboud, D. Pot, Kenna R. Margi Tanja John A. Liming Zhining Roy Jean Mills Shaw Sheth Davidsen Demchok Yang Wang Tarnuz, K. R. Mills Shaw, Margi Sheth, Tanja Davidsen, J. Demchok, Liming Yang, Zhining Wang, R. Tarnuzzer, Jean Claude Zenklusen, Bradley A. Heidi J. Ozenberger Sofia, B. Ozenberger, H. Sofia, William D. Richard Belinda Sanja Edwina William K. Peter C Travis Cheney Clarke Dacic Duhig Funkhouser Illei , E. Duhig +356 moresemanticscholar +1 more sourceProteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma.
Cell, 2020 To explore the biology of lung adenocarcinoma (LUAD) and identify new therapeutic opportunities, we performed comprehensive proteogenomic characterization of 110 tumors and 101 matched normal adjacent tissues (NATs) incorporating genomics, epigenomics ...Michael A. Gillette, S. Satpathy, Song Cao, S. Dhanasekaran, S. Vasaikar, Karsten Krug, F. Petralia, Y. Li, Wen-Wei Liang, B. Reva, R. Hong, Sara R. Savage, G. Getz, Q. Li, Bing Zhang, H. Rodriguez, K. Ruggles, A. Robles, K. Clauser, R. Govindan, Pei Wang, A. Nesvizhskii, L. Ding, D. Mani, S. Carr +24 moresemanticscholar +1 more source
