Results 91 to 100 of about 3,117,738 (383)

Microbiome profile associated with malignant pleural effusion. [PDF]

, 2020
INTRODUCTION:There is ongoing research into the development of novel molecular markers that may complement fluid cytology malignant pleural effusion (MPE) diagnosis.
Gilbert, Jack A, Gottel, Neil, Rahman, Najib M, Sanchez, Trinidad, Sharma, Anukriti, Shojaee, Samira   +5 more
core   +1 more source

Cellular liquid biopsy provides unique chances for disease monitoring, preclinical model generation and therapy adjustment in rare salivary gland cancer patients

Molecular Oncology, EarlyView.
We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić, Florian Lüke, Steffi Treitschke, Andrea Coluccio, Martin Hoffmann, Giancarlo Feliciello, Adithi Ravikumar Varadarajan, Xin Lu, Kathrin Weidele, Catherine Botteron, Silvia Materna–Reichelt, Felix Keil, Katja Evert, Florian Weber, Thomas Schamberger, Michael Althammer, Jirka Grosse, Dirk Hellwig, Christian Schulz, Stephan Seitz, Peter Ugocsai, Anke Schlenska‐Lange, Roman Mayr, Ulrich Kaiser, Wolfgang Dietmaier, Bernhard Polzer, Jens Warfsmann, Kamran Honarnejad, Tobias Pukrop, Daniel Heudobler, Christoph A. Klein, Christian Werno   +31 more
wiley   +1 more source

Mechanism of DERL3 Affecting the Proliferation, Invasion and Metastasis of Lung Adenocarcinoma A549 Cells

Chinese Journal of Lung Cancer, 2020
Background and objective Derlin 3 (DERL3) is downregulated in colorectal cancer (CRC) samples. Its level is closely linked to lymphatic metastasis or distant metastasis rate in CRC patients.
Dandan ZHOU, Jiemin WANG, Ke YANG, Liping ZHANG, Quan ZHENG, Jun BAI, Yaqiong HU, Qingjie MU, Chonggao YIN, Hongli LI   +9 more
doaj   +1 more source

Lung adenocarcinoma with giant cyst formation showing a variety of histologic patterns: a case report [PDF]

, 2010
Introduction Lung cancer with large cyst formation is relatively rare. This is a case report of a patient with lung cystic adenocarcinoma with multiple histologic patterns.
H Matsushima, N Singh, O Alpan, S Ohi, T Iwasaki, Takeshi Kondo, YN Bakri   +6 more
core   +3 more sources

Integration of single‐cell and bulk RNA‐sequencing data reveals the prognostic potential of epithelial gene markers for prostate cancer

Molecular Oncology, EarlyView.
Prostate cancer is a leading malignancy with significant clinical heterogeneity in men. An 11‐gene signature derived from dysregulated epithelial cell markers effectively predicted biochemical recurrence‐free survival in patients who underwent radical surgery or radiotherapy.
Zhuofan Mou, Lorna W. Harries
wiley   +1 more source

Widespread rash in lung adenocarcinoma

ESMO Open, 2018
A 68-year-old man is being treated with cisplatin-pemetrexed in the first line for bone metastatic lung adenocarcinoma. There is partial response and very good tolerance with no grade 3–4 toxicities. After six cycles of doublet therapy, the patient follows on pemetrexed maintenance. Six months later, he develops a hot and itchy rash with …
José Miguel Jurado, Fernando Gálvez-Montosa, Francisco Almazan   +2 more
openaire   +2 more sources

Molecular biomarkers for lung adenocarcinoma [PDF]

European Respiratory Journal, 2017
The identification of oncogenic driver alterations that underlie sensitivity to small inhibitors has led to growing interest in identifying additional targetable oncogenes in nonsmall cell lung cancer. Although the therapeutic impact of the discovery of these alterations has now been widely demonstrated, the epidemiological data associated with each of
Anne Pradines, Julien Mazieres, Olivier Calvayrac, Elvire Pons, Nicolas Guibert, Nicolas Guibert   +5 more
openaire   +3 more sources

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source

Pathologist-level classification of histologic patterns on resected lung adenocarcinoma slides with deep neural networks [PDF]

arXiv, 2019
Classification of histologic patterns in lung adenocarcinoma is critical for determining tumor grade and treatment for patients. However, this task is often challenging due to the heterogeneous nature of lung adenocarcinoma and the subjective criteria for evaluation.
arxiv  

OTUB1 triggers lung cancer development by inhibiting RAS monoubiquitination [PDF]

, 2016
Activation of the RAS oncogenic pathway, frequently ensuing from mutations in RAS genes, is a common event in human cancer. Recent reports demonstrate that reversible ubiquitination of RAS GTPases dramatically affects their activity, suggesting that ...
Asbagh, Layka Abbasi, Aushev, Vasily N, Baietti, Maria Francesca, Crowther, Jonathan, Lievens, Sam, Martínez García, David, Radaelli, Enrico, Sablina, Anna A, Simicek, Michal, Steklov, Mikhail, Tavernier, Jan   +10 more
core   +1 more source