Results 91 to 100 of about 478,988 (359)

Clinical and molecular characterization of HER2 amplified-pancreatic cancer [PDF]

, 2013
<p>Background: Pancreatic cancer is one of the most lethal and molecularly diverse malignancies. Repurposing of therapeutics that target specific molecular mechanisms in different disease types offers potential for rapid improvements in outcome ...
Biankin, A.V., Chang, D.K., Chantrill, L., Chin, V., Chou, A., Cowley, M.J., Gill, A.J., Goldstein, D., Grimmond, S.M., Humphris, J., Johns, A.L., Kassahn, K.S., Mead, R., Miller, D.K., Morey, A.L., Musgrove, E.A., Nagrial, A.M., Nones, K., Pajic, M., Patch, A.M., Pearson, J.V., Pinese, M., Rooman, I., Samra, J.S., Toon, C.W., Waddell, N., Wasan, H., Wu, J.   +27 more
core   +3 more sources

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Expression and clinical role of in lung adenocarcinoma

Journal of International Medical Research
Objective To explore the levels of expression and clinical role of peroxiredoxin 6 ( PRDX6 ) in lung adenocarcinoma. Methods This retrospective study used a series of bioinformatics methods to detect the levels of expression of and mutations in the PRDX6
Zixin Chen, Junjun Lin, Huifang Wang, Jing Wang, Zhou Zhang   +4 more
doaj   +1 more source

GSAE: an autoencoder with embedded gene-set nodes for genomics functional characterization

, 2018
Bioinformatics tools have been developed to interpret gene expression data at the gene set level, and these gene set based analyses improve the biologists' capability to discover functional relevance of their experiment design. While elucidating gene set
Chen, Hung-I Harry, Chen, Yidong, Chiu, Yu-Chiao, Huang, Yufei, Zhang, Songyao, Zhang, Tinghe   +5 more
core   +3 more sources

Isolated splenic metastasis of lung adenocarcinoma

Thoracic Cancer, 2011
AbstractSplenic metastasis from lung cancer is uncommon, and isolated metastasis to the spleen is extremely rare event. Most often they are part of widespread metastatic disease and usually reported at autopsy. We report an exceedingly rare case of metastatic involvement of the spleen in an operated case of lung adenocarcinoma in a 58‐year‐old man ...
Ihsan, Alloubi, Zouhour, Bourhaleb, Tijani, Harroudi   +2 more
openaire   +2 more sources

Lactoferrin treatment activates acetylcholinesterase, decreasing acetylcholine levels in non‐small cell lung cancer (NSCLC) cell culture supernatants, inhibiting cell survival

FEBS Open Bio, EarlyView.
Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel, Caroline Wozniak, Aya Sabri, Ben Haddad, Brooke Lopo, Alvaro Cobos, Sarah Sarofim, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evans   +9 more
wiley   +1 more source

Expression of OPN3 in lung adenocarcinoma promotes epithelial‐mesenchymal transition and tumor metastasis

Thoracic Cancer, 2020
Background Lung adenocarcinoma is the most common pathological lung cancer and an important cause of cancer‐related death. Metastasis is a major underlying reason for poor prognosis of lung adenocarcinoma.
Chao Xu, Ruixia Wang, Yanfang Yang, Tongyi Xu, Yan Li, Jie Xu, Zhansheng Jiang   +6 more
doaj   +1 more source

Multiple cystic adenocarcinoma of the lung.

Nihon Naika Gakkai Zasshi, 2001
症例は39歳,女性.主訴は乾性咳漱.胸部X線およびcomputed tomographic scanにて多発性〓胞性陰影が認められた.感染症の合併を繰り返すうちに次第に〓胞の増大が認められたため,確定診断のため胸腔鏡下肺生検を施行し肺腺癌と診断された.化学療法を行うも効果なく〓胞の増大に伴う呼吸不全にて死亡した.多発性〓胞性陰影を呈する肺癌症例は極めて稀であり,〓胞形成の機序について考察を加え報告した.
K, Kunisada, R, Komoto, Y, Tanimoto, K, Kiura, H, Ueoka, M, Kataoka, M, Harada, M, Aoe, N, Shimizu, T, Shibayama   +9 more
openaire   +3 more sources

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Impact of histopathological subtypes on invasive lung adenocarcinoma: from epidemiology to tumour microenvironment to therapeutic strategies

World Journal of Surgical Oncology
Lung adenocarcinoma is the most prevalent type of lung cancer, with invasive lung adenocarcinoma being the most common subtype. Screening and early treatment of high-risk individuals have improved survival; however, significant differences in prognosis ...
Shaowei Xin, Miaomiao Wen, Yahui Tian, Honghong Dong, Zitong Wan, Suxin Jiang, Fancheng Meng, Yanlu Xiong, Yong Han   +8 more
doaj   +1 more source