Results 221 to 230 of about 24,916 (232)

Functional aspects of Adenomatous Polyposis Coli protein dimerization and posttranslational regulation

2012
The Adenomatous Polyposis Coli (APC) tumor suppressor gene is responsible for an inherited predisposition to colon cancer through the development of multiple colorectal adenomas. Mutations in APC are also found in the majority of sporadic colorectal cancers, indicating that APC function is critical to maintenance of cell growth and differentiation in ...
openaire   +1 more source

A novel role for Adenomatous Polyposis Coli protein in the transport of mitochondria

2015
Adenomatous Polyposis Coli (APC) is a multifunctional tumour suppressor protein, contributing to pathways in normal cell growth and differentiation. APC gene mutation is one of the earliest events in the progression of colorectal cancer (CRC), and typically gives rise to a truncated protein lacking C-terminal sequences, initiating deregulation of key ...
openaire   +1 more source

Adenomatous Polyposis Coli Tumor Suppressor Protein Has Signaling Activity in Xenopus laevis Embryos Resulting in the Induction of an Ectopic Dorsoanterior Axis

Journal of Cell Biology, 1997
Kris Vleminckx, Bonnee Rubinfeld, Paul Polakis   +2 more
exaly  

Structural basis of the Axin–adenomatous polyposis coli interaction

EMBO Journal, 2000
Paul Polakis, William I Weis, P Polakis   +2 more
exaly  

Adenomatous Polyposis Coli (APC) Protein Moves along Microtubules and Concentrates at Their Growing Ends in Epithelial Cells

Journal of Cell Biology, 2000
Yuko Mimori-Kiyosue, Nobuyuki Shiina, Shoichiro Tsukita   +2 more
exaly  

Molecular mechanisms of beta-catenin recognition by adenomatous polyposis coli revealed by the structure of an APC-beta-catenin complex

EMBO Journal, 2001
William I Weis
exaly  

Apical Membrane Localization of the Adenomatous Polyposis Coli Tumor Suppressor Protein and Subcellular Distribution of the β-Catenin Destruction Complex in Polarized Epithelial Cells

Journal of Cell Biology, 2001
Barry M Gumbiner, Reinacher-Schick Anke, Gumbiner Barry M   +2 more
exaly  

Multiple products in the protein truncation test due to alternative splicing in the adenomatous polyposis coli (APC) gene

Human Genetics, 1996
Juul T Wijnen, P Meera Khan, Wolfgang G Ballhausen   +2 more
exaly  

Expression of Adenomatous Polyposis Coli Protein in Reactive Astrocytes in Hippocampus of Kainic Acid-Induced Rat

Neurochemical Research, 2009
Ha Na Lee, G. Jeon, D. Kim, I. Cho, S. Cho   +4 more
semanticscholar   +1 more source

Relationship between the role of the adenomatous polyposis coli protein in colon cancer and its contribution to cytoskeletal regulation.

Biochemical Society Transactions, 2005
I. Näthke
semanticscholar   +1 more source