Results 201 to 210 of about 30,293 (217)

Expressions of two adenomatous polyposis coli and E-cadherin proteins on human colorectal cancers

Virchows Archiv, 2003
Mutations in the adenomatous polyposis coli (APC) gene contribute to the progression of colorectal tumorigenesis. Despite the importance, few studies regarding the localization of this protein on surgically resected human colorectal cancer specimens using immunohistochemistry have been reported so far because of the unavailability of the antibodies for
Koh, Furuta, Shingo, Yoshioka, Satoko, Okabe, Masato, Ikeda, Mihoko, Oginosawa, Seiyo, Ikeda, Yoshifuku, Nakayama, Masahiro, Kikuchi, Stanley R, Hamilton   +8 more
openaire   +2 more sources

Phosphorylation of the Adenomatous Polyposis Coli Protein and Its Possible Regulatory Effects in Cells

Biochemical and Biophysical Research Communications, 1995
The adenomatous polyposis coli (APC) gene is etiologically associated with familial adenomatous polyposis and gastrointestinal malignancies, but its cellular function and role in tumorigenesis are unclear. Recent reports indicate that wild-type, but not mutant, APC gene product (APC) is associated with and promotes the assembly of cytoskeletal ...
G, Bhattacharya, B M, Boman
openaire   +2 more sources

Detection of Cytoplasmic and Nuclear Localization of Adenomatous Polyposis Coli (APC) Protein in Cells

2008
The adenomatous polyposis coli (APC) tumour suppressor gene is mutated in the majority of colon cancers. APC is a multi-domain protein whose distribution at different subcellular locations correlates with unique cellular processes. Our laboratory has focused on the link between APC subcellular location and function, and has characterized pathways for ...
Mariana, Brocardo, Beric R, Henderson
openaire   +2 more sources

Functional aspects of Adenomatous Polyposis Coli protein dimerization and posttranslational regulation

2012
The Adenomatous Polyposis Coli (APC) tumor suppressor gene is responsible for an inherited predisposition to colon cancer through the development of multiple colorectal adenomas. Mutations in APC are also found in the majority of sporadic colorectal cancers, indicating that APC function is critical to maintenance of cell growth and differentiation in ...
openaire   +1 more source

The adenomatous polyposis coli tumor suppressor protein localizes to plasma membrane sites involved in active cell migration.

Journal of Cell Biology, 1996
Inke S Näthke
exaly  

Adenomatous Polyposis Coli Tumor Suppressor Protein Has Signaling Activity in Xenopus laevis Embryos Resulting in the Induction of an Ectopic Dorsoanterior Axis

Journal of Cell Biology, 1997
Kris Vleminckx
exaly  

Structural basis of the Axin–adenomatous polyposis coli interaction

EMBO Journal, 2000
William I Weis
exaly  

Adenomatous Polyposis Coli (APC) Protein Moves along Microtubules and Concentrates at Their Growing Ends in Epithelial Cells

Journal of Cell Biology, 2000
Yuko Mimori-Kiyosue, Nobuyuki Shiina
exaly  

NH2-terminal Deletion of β-Catenin Results in Stable Colocalization of Mutant β-Catenin with Adenomatous Polyposis Coli Protein and Altered MDCK Cell Adhesion

Journal of Cell Biology, 1997
Keith E Mostov
exaly  

Molecular mechanisms of beta-catenin recognition by adenomatous polyposis coli revealed by the structure of an APC-beta-catenin complex

EMBO Journal, 2001
William I Weis
exaly