Results 201 to 210 of about 24,916 (232)
Some of the next articles are maybe not open access.
A role for the Adenomatous Polyposis Coli protein in chromosome segregation
Nature Cell Biology, 2001Mutations in the Adenomatous Polyposis Coli (APC) gene are responsible for familial colon cancer and also occur in the early stages of sporadic colon cancer. APC functions in the Wnt signalling pathway to regulate the degradation of beta-catenin (reviewed in refs 1-3).
Kaplan, Kenneth B. +5 more
openaire +4 more sources
The adenomatous polyposis coli protein: in the limelight out at the edge
Trends in Cell Biology, 2001Truncation mutations in the adenomatous polyposis coli protein (APC) are responsible for familial and sporadic colonic tumours. APC is best known for its role in regulating beta-catenin, an important mediator of cell adhesion and a transcriptional activator. However, recent studies indicate that APC has additional roles in cytoskeletal regulation.
D, Dikovskaya +3 more
openaire +3 more sources
Adenomatous polyposis coli proteins and cell adhesion
Current Opinion in Cell Biology, 2004Adenomatous polyposis coli (APC) is an important tumour suppressor in the mammalian intestinal epithelium. It binds to beta-catenin and its role as a tumour suppressor depends predominantly on its ability to downregulate soluble beta-catenin, a key effector of the Wnt signalling pathway.
Mariann Bienz, Fumihiko Hamada
exaly +3 more sources
Aspirin augments the expression of Adenomatous Polyposis Coli protein by suppression of IKKβ
Biochemical and Biophysical Research Communications, 2014Aspirin has been widely used as analgesic, antipyretic and anti-inflammatory medicine for long. In addition to these traditional effects, clinical studies suggest that aspirin can protect against cancer, but its mechanism has not been explored. To unveil it, we identified the proteins up- or down-regulated after incubation with aspirin by using ...
Noboru Ashida, Kaeko Kamei
exaly +3 more sources
Non-traditional roles for the Adenomatous Polyposis Coli (APC) tumor suppressor protein
Gene, 2005The Adenomatous Polyposis Coli (APC) tumor suppressor is a multifunctional protein that is mutated in a majority of colon cancers. The role of APC as an antagonist of the Wnt signaling pathway is well known and it is widely accepted that inappropriate activation of this pathway through loss of APC function contributes to the progression of colon ...
Caroline A, Hanson, Jeffrey R, Miller
exaly +3 more sources
Neuroscience, 1998
The adenomatous polyposis coli gene is mutated in familial adenomatous polyposis and in sporadic colorectal tumours. The adenomatous polyposis coli gene product is a 300,000 mol. wt cytoplasmic protein that binds to at least three other proteins; beta-catenin, a cytoplasmic E-cadherin-associated protein; hDLG, a human homologue of the Drosophila discs ...
Takao Senda +2 more
exaly +3 more sources
The adenomatous polyposis coli gene is mutated in familial adenomatous polyposis and in sporadic colorectal tumours. The adenomatous polyposis coli gene product is a 300,000 mol. wt cytoplasmic protein that binds to at least three other proteins; beta-catenin, a cytoplasmic E-cadherin-associated protein; hDLG, a human homologue of the Drosophila discs ...
Takao Senda +2 more
exaly +3 more sources
International Journal of Surgical Pathology, 2002
The aim of this study was to investigate protein expression of adenomatous polypois coli (APC) in primary and metastatic serous ovarian carcinoma. The expression of 3-catenin and E-cadherin was additionally analyzed. One hundred and thirteen priary (n=56) and metastatic (n=57) lesions were immunohistochemically stained for APC, E-cadherin, and f ...
Ben Davidson, Claes G Tropé
exaly +3 more sources
The aim of this study was to investigate protein expression of adenomatous polypois coli (APC) in primary and metastatic serous ovarian carcinoma. The expression of 3-catenin and E-cadherin was additionally analyzed. One hundred and thirteen priary (n=56) and metastatic (n=57) lesions were immunohistochemically stained for APC, E-cadherin, and f ...
Ben Davidson, Claes G Tropé
exaly +3 more sources
Adenomatous polyposis coli protein regulates the cellular response to DNA replication stress
The International Journal of Biochemistry & Cell Biology, 2011The adenomatous polyposis coli (APC) tumor suppressor traffics between nucleus and cytoplasm to perform distinct functions. Here we identify a specific role for APC in the DNA replication stress response. The silencing of APC caused an accumulation of asynchronous cells in early S phase and delayed S phase progression in cells released from hydroxyurea-
Mariana G, Brocardo +2 more
openaire +3 more sources
Biochemical and Biophysical Research Communications, 1995
The adenomatous polyposis coli (APC) gene is etiologically associated with familial adenomatous polyposis and gastrointestinal malignancies, but its cellular function and role in tumorigenesis are unclear. Recent reports indicate that wild-type, but not mutant, APC gene product (APC) is associated with and promotes the assembly of cytoskeletal ...
G, Bhattacharya, B M, Boman
openaire +3 more sources
The adenomatous polyposis coli (APC) gene is etiologically associated with familial adenomatous polyposis and gastrointestinal malignancies, but its cellular function and role in tumorigenesis are unclear. Recent reports indicate that wild-type, but not mutant, APC gene product (APC) is associated with and promotes the assembly of cytoskeletal ...
G, Bhattacharya, B M, Boman
openaire +3 more sources
Journal of Cell Biology, 1997 β-Catenin is essential for the function of cadherins, a family of Ca2+-dependent cell–cell adhesion molecules, by linking them to α-catenin and the actin cytoskeleton.
Angela I M Barth +2 more
exaly +2 more sources