Results 191 to 200 of about 30,293 (217)

The adenomatous polyposis coli protein 3o years on

2022
ABSTRACTMutations in the gene encoding the Adenomatous polyposis coli protein (APC) were discovered as driver mutations in colorectal cancers almost 30 years ago. Since then, the importance of APC in normal tissue homeostasis has been confirmed in a plethora of other (model) organisms spanning a large evolutionary space.
James Abbott, Inke S. Näthke
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A role for the Adenomatous Polyposis Coli protein in chromosome segregation

Nature Cell Biology, 2001
Mutations in the Adenomatous Polyposis Coli (APC) gene are responsible for familial colon cancer and also occur in the early stages of sporadic colon cancer. APC functions in the Wnt signalling pathway to regulate the degradation of beta-catenin (reviewed in refs 1-3).
Kaplan, Kenneth B., Burds, Aurora A., Swedlow, Jason R., Bekir, Songül S., Sorger, Peter K., Näthke, Inke S.   +5 more
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Adenomatous polyposis coli, protein kinases, protein tyrosine phosphatase: The effect of sulindac

Journal of Surgical Oncology, 1995
AbstractA putative explanation of the effect of sulindac on adenomatous colon and duodenal polyps from clinical observations and related in vitro experiments is presented. In cells with mutant APC genes, persistent high prostaglandin content of polyps leads to desensitization, downregulation of adenylate cyclase, uncoupling of cAMP synthesis from ...
W R, Waddell, R L, Miesfeld
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The adenomatous polyposis coli tumor suppressor protein and microtubule dynamics

Current Colorectal Cancer Reports, 2007
Colorectal cancer is closely associated with mutation of the gene encoding the adenomatous polyposis coli (APC) tumor suppressor protein. A role has been defined for APC in the Wnt signaling pathway, in which it is responsible for mediating the degradation of the protein β-catenin.
Anke Brüning-Richardson, Ewan E. Morrison   +1 more
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Truncated adenomatous polyposis coli (APC) tumour suppressor protein can undergo tyrosine phosphorylation

European Journal of Cancer, 2000
Numerous mutations in the adenomatous polyposis coli (APC) gene have been described in colorectal cancer. The vast majority introduce nonsense codons leading to the production of truncated N-terminal APC fragments. Mutations occurring before APC codon 158, have been associated with an attenuated form of familial adenomatous polyposis whereas those ...
A L, Norris, P M, Clissold, J M, Askham, E E, Morrison, P, Moncur, S H, McCall, P L, Coletta, D M, Meredith, A F, Markham   +8 more
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The adenomatous polyposis coli protein: in the limelight out at the edge

Trends in Cell Biology, 2001
Truncation mutations in the adenomatous polyposis coli protein (APC) are responsible for familial and sporadic colonic tumours. APC is best known for its role in regulating beta-catenin, an important mediator of cell adhesion and a transcriptional activator. However, recent studies indicate that APC has additional roles in cytoskeletal regulation.
D, Dikovskaya, J, Zumbrunn, G A, Penman, I S, Näthke   +3 more
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Adenomatous polyposis coli protein regulates the cellular response to DNA replication stress

The International Journal of Biochemistry & Cell Biology, 2011
The adenomatous polyposis coli (APC) tumor suppressor traffics between nucleus and cytoplasm to perform distinct functions. Here we identify a specific role for APC in the DNA replication stress response. The silencing of APC caused an accumulation of asynchronous cells in early S phase and delayed S phase progression in cells released from hydroxyurea-
Mariana G, Brocardo, James A, Borowiec, Beric R, Henderson   +2 more
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THE ADENOMATOUS POLYPOSIS COLI PROTEIN: The Achilles Heel of the Gut Epithelium

Annual Review of Cell and Developmental Biology, 2004
▪ Abstract  The Adenomatous Polyposis coli (APC) gene is mutated or lost in most colon cancers, and the APC protein has emerged as a multifunctional protein that is not only involved in the Wnt-regulated degradation of β-catenin, but also regulates cytoskeletal proteins and thus plays a role in cell migration, cell adhesion, and mitosis.
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Regulated nuclear import of the adenomatous polyposis coli protein.

2012
Mutation of the Adenomatous Polyposis Coli (APC) gene is an early step in the development of colorectal carcinomas. To provide clues for APC's role in tumor suppression, the subcellular distribution of APC was studied, and APC was found to localize to both the cytoplasm and the nucleus of normal human epithelial cells. The objectives of this study were
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Ca2+ regulates the subcellular localization of adenomatous polyposis coli tumor suppressor protein

Biochemical and Biophysical Research Communications, 2009
Microtubule (MT) plus-end tracking proteins (+TIPs) are involved in the regulation of MT plus-end dynamics and stabilization. It was reported previously that an increase in intracellular Ca(2+) concentration ([Ca(2+)](i)) induced by disruption of the plasma membrane stimulates rearrangement of MTs [T.
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