Results 191 to 200 of about 24,916 (232)

Impact of MiRNAs on Wnt-related gene activity in breast cancer. [PDF]

Sci Rep
Sirek T, Sirek A, Zmarzły N, Opławski M, Król-Jatręga K, Boroń D, Chalcarz M, Ossowski P, Dziobek K, Strojny D, Szymańska J, Gajdeczka J, Borawski P, Boroń K, Grabarek BO.   +14 more
europepmc   +1 more source

Diagnostic and Clinical Significance of the Special AT-Rich Sequence-Binding Protein 2 Deregulation in Gastrointestinal Malignancies. [PDF]

Maedica (Bucur)
Davris D, Falidas E, Adamopoulou M, Tsiambas E, Metaxas IE, Poultsidi A, Tzovaras G, Zacharoulis D.   +7 more
europepmc   +1 more source

Low Yield of Genetic Testing in Serrated Polyposis Syndrome. [PDF]

Clin Transl Gastroenterol
Upadhye I, Al Maliki H, Cuthill V, Latchford A, Monahan K.   +4 more
europepmc   +1 more source

Suppressor protein plasma levels and inflammatory indices in colorectal cancer patients. [PDF]

BMC Cancer
Chigvinadze N, Pantsulaia I, Lejava T, Aladashvili A, Atamashvili T, Khvichia N, Rekhviashvili K.   +6 more
europepmc   +1 more source

Integrated perspectives on colorectal carcinogenesis: molecular pathogenesis, genomic alterations, diagnostic paradigms, therapeutic interventions and AI-driven directions in precision oncology. [PDF]

Front Oncol
N SK, S SK, Ramasamy M.
europepmc   +1 more source

Development of Primary Colon and Duodenal Tumor Cultures from the Apc-mutant Pirc Rat for Screening Preventive Agents. [PDF]

J Cancer Prev
Muhsin A, Neja S, Mohan N, Kapoor S, Perez JET, Dashwood WM, Rashid A, Dashwood R, Rajendran P.   +8 more
europepmc   +1 more source

Advances in research on congenital and hereditary intestinal diseases: From molecular mechanisms to precision medicine. [PDF]

Intractable Rare Dis Res
Yang L, Wang Y, Yuan L, Tang W.
europepmc   +1 more source

The adenomatous polyposis coli protein 3o years on [PDF]

bioRxiv, 2022
ABSTRACT Mutations in the gene encoding the Adenomatous polyposis coli protein (APC) were discovered as driver mutations in colorectal cancers almost 30 years ago. Since then, the importance of APC in normal tissue homeostasis has been confirmed in a plethora of other (model) organisms spanning a large evolutionary space.
James Abbott, Inke S. Näthke
semanticscholar   +3 more sources

THE ADENOMATOUS POLYPOSIS COLI PROTEIN: The Achilles Heel of the Gut Epithelium

Annual Review of Cell and Developmental Biology, 2004
▪ Abstract  The Adenomatous Polyposis coli (APC) gene is mutated or lost in most colon cancers, and the APC protein has emerged as a multifunctional protein that is not only involved in the Wnt-regulated degradation of β-catenin, but also regulates cytoskeletal proteins and thus plays a role in cell migration, cell adhesion, and mitosis.
I. Näthke
semanticscholar   +5 more sources

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Adenomatous Polyposis Coli Protein is Expressed in Alternate Stages of the Ameloblast Life Cycle

Journal of Dental Research, 1998
Mutations of the adenomatous polyposis coli gene protein (APC) are associated with familial polyposis and also sporadic colon adenomas, both preconditions to cancer formation. Some familial polyposis patients also develop Gardner's syndrome, a condition characterized by supernumerary teeth, mandibular osteomas, and other maladies.
Barbara C Sorkin, Z Skobe
exaly   +4 more sources