Results 211 to 220 of about 24,916 (232)
Scandinavian Journal of Gastroenterology, 1996 Background: More than 100 different mutations in the adenomatous polyposis coli (APC) gene have been identified; virtually all lead to the production of a truncated protein.
Nicoletta Resta +2 more
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The adenomatous polyposis coli tumor suppressor protein localizes to plasma membrane sites involved in active cell migration. [PDF]
Journal of Cell Biology, 1996 Mutations in the adenomatous polyposis coli (APC) gene are linked to polyp formation in familial and sporadic colon cancer, but the functions of the protein are not known.
Inke Näthke +2 more
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Genotype-Phenotype Correlations in Attenuated Adenomatous Polyposis Coli
American Journal of Human Genetics, 1998 SummaryGerm-line mutations of the tumor suppressor APC are implicated in attenuated adenomatous polyposis coli (AAPC), a variant of familial adenomatous polyposis (FAP). AAPC is recognized by the occurrence of 40 years).
C Soravia, Terri Berk, Lisa Madlensky
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Adenomatous polyposis coli, protein kinases, protein tyrosine phosphatase: The effect of sulindac
Journal of Surgical Oncology, 1995AbstractA putative explanation of the effect of sulindac on adenomatous colon and duodenal polyps from clinical observations and related in vitro experiments is presented. In cells with mutant APC genes, persistent high prostaglandin content of polyps leads to desensitization, downregulation of adenylate cyclase, uncoupling of cAMP synthesis from ...
W R, Waddell, R L, Miesfeld
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The adenomatous polyposis coli tumor suppressor protein and microtubule dynamics
Current Colorectal Cancer Reports, 2007Colorectal cancer is closely associated with mutation of the gene encoding the adenomatous polyposis coli (APC) tumor suppressor protein. A role has been defined for APC in the Wnt signaling pathway, in which it is responsible for mediating the degradation of the protein β-catenin.
Anke Brüning-Richardson +1 more
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2008
The adenomatous polyposis coli (APC) tumour suppressor gene is mutated in the majority of colon cancers. APC is a multi-domain protein whose distribution at different subcellular locations correlates with unique cellular processes. Our laboratory has focused on the link between APC subcellular location and function, and has characterized pathways for ...
Mariana, Brocardo, Beric R, Henderson
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The adenomatous polyposis coli (APC) tumour suppressor gene is mutated in the majority of colon cancers. APC is a multi-domain protein whose distribution at different subcellular locations correlates with unique cellular processes. Our laboratory has focused on the link between APC subcellular location and function, and has characterized pathways for ...
Mariana, Brocardo, Beric R, Henderson
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Regulated nuclear import of the adenomatous polyposis coli protein.
2012Mutation of the Adenomatous Polyposis Coli (APC) gene is an early step in the development of colorectal carcinomas. To provide clues for APC's role in tumor suppression, the subcellular distribution of APC was studied, and APC was found to localize to both the cytoplasm and the nucleus of normal human epithelial cells. The objectives of this study were
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Expressions of two adenomatous polyposis coli and E-cadherin proteins on human colorectal cancers
Virchows Archiv, 2003Mutations in the adenomatous polyposis coli (APC) gene contribute to the progression of colorectal tumorigenesis. Despite the importance, few studies regarding the localization of this protein on surgically resected human colorectal cancer specimens using immunohistochemistry have been reported so far because of the unavailability of the antibodies for
Koh, Furuta +8 more
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APC GENE-MUTATIONS IN FAMILIAL ADENOMATOUS POLYPOSIS-COLI IDENTIFIED AT THE DNA AND PROTEIN LEVEL
International Journal of Oncology, 1993Peripheral blood cell DNA of patients suffering from Familial Adenomatous Polyposis coli (FAP) were subjected to SSCP screening analyses. Here, we report on a patient, who was diagnosed at the age of 31 years suffering from a severe form of adenomatous polyposis coli.
C, Kraus +3 more
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Ca2+ regulates the subcellular localization of adenomatous polyposis coli tumor suppressor protein
Biochemical and Biophysical Research Communications, 2009Microtubule (MT) plus-end tracking proteins (+TIPs) are involved in the regulation of MT plus-end dynamics and stabilization. It was reported previously that an increase in intracellular Ca(2+) concentration ([Ca(2+)](i)) induced by disruption of the plasma membrane stimulates rearrangement of MTs [T.
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