Results 111 to 120 of about 892,163 (354)

Endogenous adenosine maintains cartilage homeostasis and exogenous adenosine inhibits osteoarthritis progression

Nature Communications, 2017
Osteoarthritis (OA) is characterized by cartilage destruction and chondrocytes have a central role in this process. With age and inflammation chondrocytes have reduced capacity to synthesize and maintain ATP, a molecule important for cartilage ...
Carmen Corciulo, M. Lendhey, T. Wilder, Hanna Schoen, Alexander Samuel Cornelissen, Gregory Chang, O. Kennedy, B. Cronstein   +7 more
semanticscholar   +1 more source

MALAT1’s m6A Modification by METTL3 Promotes Pyroptosis and Inflammation in Sepsis-Induced Acute Kidney Injury in Mice

Journal of Inflammation Research
Pengwei Guo,1,* Gao Deng,1,* Lingling Li,1 Haidong Wei,1 Yunxia Gong,1 Yanhong Tan,1 Yanfei Ma2 1Department of Nephrology, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise City, Guangxi Zhuang Autonomous Region,
Guo P, Deng G, Li L, Wei H, Gong Y, Tan Y, Ma Y   +6 more
doaj  

Lung Injury Pathways: Adenosine Receptor 2B Signaling Limits Development of Ischemic Bronchiolitis Obliterans Organizing Pneumonia [PDF]

, 2017
Purpose/Aim of the Study: Adenosine signaling was studied in bronchiolitis obliterans organizing pneumonia (BOOP) resulting from unilateral lung ischemia. Materials and Methods: Ischemia was achieved by either left main pulmonary artery or complete hilar
Auchampach, John, Audi, Said H., Densmore, John C., Dwinell, Melinda R., Geurts, Aron M., Jacobs, Elizabeth R., Jeziorczak, Paul M., Medhora, Meetha, Nayak, Shraddha, Schaid, Terry R.   +9 more
core   +1 more source

Oxygenation inhibits the physiological tissue-protecting mechanism and thereby exacerbates acute inflammatory lung injury [PDF]

, 2005
Acute respiratory distress syndrome (ARDS) usually requires symptomatic supportive therapy by intubation and mechanical ventilation with the supplemental use of high oxygen concentrations.
, Agorreta, Ahmad, Akio Ohta, Alexander Chouker, Andonegui, Apasov, Bell, Bosco, Brown, Carvalho, Charles Caldwell, Chen, Chris Haslett, Decking, Derevianko, Dharmana, Dmitry Lukashev, Edward Jackson, Eltzschig, Estenssoro, Freeman, Gardinali, Goss, Guida, Hasko, Headley, Iris Bittmann, Ishida, Khoa, Kotani, Lachmann, Lahat, LeClaire, Leeper-Woodford, Linden, Lukashev, Madjdpour, Malbouisson, Manfred Thiel, Martin, Matuschak, Michail V Sitkovsky, Nader-Djalal, Ndengele, Ohta, Patrick Smith, Pietersma, Pinhu, Pizov, Regel, Simms, Sitkovsky, Sue, Sullivan, Tateda, Thiel, Thiel, Tremblay, Tsan, Uchiba, Ward, Wieland   +62 more
core   +5 more sources

The Diverse Neuromuscular Spectrum of VPS13A Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective VPS13A disease (chorea‐acanthocytosis) is a rare neurodegenerative disorder caused by biallelic variants in VPS13A, typically presenting with hyperkinetic movement disorders, while neuromuscular signs are often mild. The aim of the project was to investigate the frequency and severity of neuromuscular impairment in VPS13A disease ...
Anne Buchberger, Evamaria Riedel, Marie Hackenberg, Alexander Mensch, Stefanie Beck‐Woedl, Joohyun Park, Tobias B. Haack, Bernhard Haslinger, Jan Kirschke, Holger Prokisch, Andreas Hermann, Christian Mawrin, Adrian Danek, Benedikt Schoser, Kevin Peikert, Marcus Deschauer, Isabell Cordts   +16 more
wiley   +1 more source

Clinico-genetic Analysis of Adenosine Signaling Pathway in Drug-Resistant Epilepsy

Annals of Indian Academy of Neurology
Background and Objectives: The adenosine pathway in drug-resistant epilepsy (DRE) due to hippocampal sclerosis (HS) is largely unexplored. The present study aims to provide new insights into the role of adenosine pathway in patients with DRE associated ...
Vikas Dhiman, Kalpita Karan, Parthasarathy Satischandra, Anita Mahadevan, Arivazhagan Arimappamagan, Rose D Bharath, Dharma Raj, Kandavel Thennarasu, Lakshminarayanpuram G Viswanathan, Ravindranadh Mundlamuri, Raghavendra Kenchaiah, Ajay Asranna, Jitender Saini, Jamuna R Rajeswaran, Keshav Kumar, Malla Bhaskara Rao, Anuranjan Anand, Sanjib Sinha   +17 more
doaj   +1 more source

SNUPN‐Related Muscular Dystrophy: Novel Phenotypic, Pathological and Functional Protein Insights

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SNUPN‐related muscular dystrophy or LGMDR29 is a new entity that covers from a congenital or childhood onset pure muscular dystrophy to more complex phenotypes combining neurodevelopmental features, cataracts, or spinocerebellar ataxia. So far, 12 different variants have been described.
Nuria Muelas, Pablo Iruzubieta, Alberto Damborenea, Laura Pérez‐Fernández, Inmaculada Azorín, Juan Carlos Jiménez García, Ana Töpf, Pilar Martí, Lorena Fores‐Toribio, María Manterola, Rosana Blanco‐Mañez, Oihane Pikatza‐Menoio, Sonia Alonso‐Martín, Volker Straub, Aitziber L. Cortajarena, Adolfo López de Munain, David De Sancho, Lorea Blázquez, Juan J. Vilchez   +18 more
wiley   +1 more source

Metal Nanoclusters for Cancer Imaging and Treatment

Advanced Functional Materials, EarlyView.
This review aims to provide a comprehensive summary and discussion of the core–shell design capabilities of metal nanoclusters (NCs) at the atomic level for cancer imaging and treatment. It offers essential insights into the design principles of metal NCs while also encouraging the exploration of other nanomaterials and their potential theranostic ...
Haiguang Zhu, Ziping Wang, Qiaofeng Yao, Ping Zhang, Jianping Xie, Xun Yuan   +5 more
wiley   +1 more source

Editorial: Adenosine pathways in cancer immunity and immunotherapy

Frontiers in Immunology, 2023
Junjiang Fu, Luca Antonioli, Ali H. El-Far   +2 more
doaj   +1 more source

Ischemic preconditioning attenuates portal venous plasma concentrations of purines following warm liver ischemia in man [PDF]

, 2005
Background/Aims: Degradation of adenine nucleotides to adenosine has been suggested to play a critical role in ischemic preconditioning (IPC). Thus, we questioned in patients undergoing partial hepatectomy whether (i) IPC will increase plasma purine ...
Chouker, A., Dugas, Martin, Heizmann, O., Martignoni, A., Messmer, K., Peter, K., Rau, H. G., Schauer, R. J., Thiel, M., Volk, A.   +9 more
core   +1 more source