Results 221 to 230 of about 617,017 (357)

Immunomodulatory Fibrous Scaffold with Dual Enzyme‐Mimic Activities Prevents Postsurgical Tumor Recurrence

Advanced Science, EarlyView.
A MnOx nanozyme‐functionalized electrospun fibrous scaffold is developed for postoperative therapy by leveraging its intrinsic physicochemical and immunomodulatory properties. Integrating POD‐ and CAT‐like activities, the scaffold induces immunogenic cell death, alleviates hypoxia, and reverses immunosuppression, while simultaneously recruiting and ...
Xiaoyi Zhao, Zhuolong Jiao, Yue Wang, Huimeng Gu, Longfei Li, Jian Song, Chen Xu, Jiajia Xue, Fu‐Jian Xu, Nana Zhao   +9 more
wiley   +1 more source

The agonist affinity state of A1 adenosine receptors is influenced byprotonation

, 1990
Edmund Hoppe, Martin Reddington
openalex   +1 more source

Purinergic signaling and cholangiocyte regeneration: a new frontier in ischemic liver injury. [PDF]

Front Transplant
Nwaduru C, Anyagwa OE, Fenlon M, Buff M, Selim M, Botha J, Kastenberg Z, Zimmerman M.   +7 more
europepmc   +1 more source

Adenosine as a Multi-Signalling Guardian Angel in Human Diseases: When, Where and How Does it Exert its Protective Effects?

TIPS - Trends in Pharmacological Sciences, 2016
P. Borea, S. Gessi, S. Merighi, K. Varani   +3 more
semanticscholar   +1 more source

Cellular Identity Crisis: RD3 Loss Fuels Plasticity and Immune Silence in Progressive Neuroblastoma

Advanced Science, EarlyView.
Researchers discovered that therapy‐induced loss of RD3 protein in neuroblastoma triggers a dangerous shift: cancer cells become more stem‐like, invasive, and resistant to treatment while evading immune detection. RD3 loss suppresses antigen presentation and boosts immune checkpoints, creating an immune‐silent environment.
Poorvi Subramanian, Sreenidhi Mohanvelu, Sheeja Aravindan, Afsana Parveen Jahir Hussain, Sivasubramani Narayanan, Sabir Salim, Loganayaki Periyasamy, Natarajan Aravindan   +7 more
wiley   +1 more source

Intestinal epithelial Smad7 drives purine metabolic dysregulation and ileal inflammation. [PDF]

J Biomed Sci
Laudisi F, Serra MA, Tomassini L, Fantini MC, Monasterio G, He N, Sommella EM, Ortenzi A, Sica GS, Zorzi F, Pacifico T, Melaiu O, De Stefanis C, D'Oria V, Stolfi C, Monteleone I, Villablanca EJ, Monteleone G.   +17 more
europepmc   +1 more source

IGFBP5 Restores Endometrial Receptivity and Rescues Implantation Failure in Polycystic Ovary Syndrome

Advanced Science, EarlyView.
Impaired endometrial receptivity contributes to the poor pregnancy outcomes in women with PCOS. The authors found that decreased endometrial IL‐22 levels and disrupted STAT3‐IGFBP5 signaling pathway contributed to impaired endometrial receptivity. Supplementation with IL‐22 or IGFBP5 exerts a protective effect on implantation failure in PCOS‐like mice,
Baoying Liao, Chuyu Yun, Hongying Shan, Yuqian Wang, Xiunan Chen, Weisi Lian, Tianliu Peng, Min Zhao, Xunsi Qin, Kailun Hu, Ping Zhou, Yue Wang, Yanli Pang, Rong Li   +13 more
wiley   +1 more source

Selective sinoatrial suppression during post-ablation adenosine testing without atrioventricular block. [PDF]

Eur Heart J Case Rep
Mondal S, Muslim NA.
europepmc   +1 more source

Pathological overproduction: the bad side of adenosine

British Journal of Pharmacology, 2017
P. Borea, S. Gessi, S. Merighi, F. Vincenzi, K. Varani   +4 more
semanticscholar   +1 more source

Genetic Control of Tissue Remodeling by a Non‐Coding SNP in ITGA8 Explains Carotenoid‐Based Color Polymorphism in Marine Mollusks

Advanced Science, EarlyView.
In this study, the orange‐muscle giant abalone (Haliotis gigantea) is used as a model to identify a non‐coding SNP that disrupts the interaction between ITGA8 pre‐mRNA and the splicing factor ILF2, leading to altered ITGA8 splicing. These splicing changes promote carotenoid accumulation in abalone muscle through the regulation of tissue remodeling ...
Xiaohui Wei, Wenzhu Peng, Zekun Huang, Bingye Yang, Yiyu Wu, Minzhen Han, Yi Wang, Bingling Peng, Guosheng Hu, Jiawei Hong, Guijia Liu, Linwei Nie, Yang Gan, Miaoqin Huang, Xuan Luo, Weiwei You, Wen Liu, Caihuan Ke   +17 more
wiley   +1 more source