Results 221 to 230 of about 869,856 (392)

Bispecific Antibody Targeting VEGF/TGF‐β Synergizes with Local Radiotherapy: Turning Tumors from Cold to Inflamed and Amplifying Abscopal Effects

open access: yesAdvanced Science, EarlyView.
Y332D, a bispecific antibody that simultaneously blockades VEGF and TGF‐β, counteracted negative RT effects that are attributed to the upregulation of TGF‐β and VEGF, as well as further enhanced the immunostimulatory effects of RT, thereby reprograming the TME from immune “cold” to inflamed state and forming an effective in‐situ vaccine that eradicate ...
Lijuan Lyu   +13 more
wiley   +1 more source

Effect of a single ultra processed meal on myocardial endothelial function, adenosine mediated effects and cognitive performances. [PDF]

open access: yesSci Rep
Lucinian YA   +11 more
europepmc   +1 more source

The Breakdown of Adenosine Triphosphate in Human Blood. [PDF]

open access: bronze, 1956
Søren Jørgensen   +4 more
openalex   +1 more source

ATF3 Deficiency Exacerbates Ageing‐Induced Atherosclerosis and Clinical Intervention Strategy

open access: yesAdvanced Science, EarlyView.
Targeting ATF3 with terazosin to against VSMC Senescence and atherosclerosis. TZ reduces the binding affinity of YTHDF2 to Atf3 mRNA, while enhancing mRNA stability. ATF3 promotes Atg7 transcription, enhancing autophagy. ATG7 binds to ATF3 in the cytoplasm, facilitating ATF3 translocation to the nucleus and establishing positive feedback. By modulating
Hao Nie   +11 more
wiley   +1 more source

Dopamine D1 Receptor Contributes to Glucocorticoid‐Associated Osteonecrosis of Femoral Head Protection Through the ATF3/CHOP Axis to Inhibit Osteoblastic Apoptosis

open access: yesAdvanced Science, EarlyView.
This work identifies a novel mechanism by which dopamine D1 receptor (DRD1) contributes to the pathogenesis of glucocorticoid (GC)‐associated osteonecrosis of the femoral head (ONFH) through the regulation of osteoblastic apoptosis, indicating that DRD1 serves as a critical mediator of the crosstalk between the nervous and skeletal systems.
Kai Zheng   +11 more
wiley   +1 more source

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