Results 331 to 340 of about 869,856 (392)

Engineering Neutrophil Vesicles for Synergistic Protection against Ischemia/Reperfusion Injury after Lung Transplant

Advanced Science, EarlyView.
Engineered neutrophil‐derived vesicles (SOD2‐Fer‐1@CVs) co‐delivering antioxidant and ferroptosis‐inhibitory agents enable inflammation‐targeted, ROS‐responsive therapy for ischemia–reperfusion injury in lung transplantation. Synergizing with ex vivo lung perfusion, this strategy alleviates oxidative stress and inflammation, restores vascular integrity,
Hao‐Xiang Yuan, Yu‐Yun Ye, Pu Shen, Jie Zhang, Qian‐Fang Meng, Ying Chen, Xin Xu, Xuan‐Lin Zhang, Lang Rao, Zhi‐Jin Fan, Jian‐Xing He   +10 more
wiley   +1 more source

Landscape of targets within nucleoside metabolism for the modification of immune responses. [PDF]

Front Oncol
Dunderdale EM, Abt ER.
europepmc   +1 more source

A Needle‐Like H2S‐Releasing and H2O2 Self‐Replenishing Nanoplatform for Enhanced Chemodynamic Tumor Immunotherapy

Advanced Science, EarlyView.
The PTA‐SnS2@GOx cascade nanosystem presents a smart paradigm for cancer theranostics, integrating self‐supplied H2S/H2O2‐augmented chemodynamic therapy (CDT) with sensitized immunotherapy. Its needle‐like SnS2 shell enhances tumor‐specific uptake, ensuring biosafety.
Xiaoxiao Sun, Xia Zhang, Haiyan Qin, Lingling Li   +3 more
wiley   +1 more source

P2X7 a new therapeutic target to block vesicle-dependent metastasis in colon carcinoma: Role of the A2A/CD39/CD73 axis. [PDF]

Cell Death Dis
Pegoraro A, De Marchi E, Ruo L, Zanoni M, Chioccioli S, Caderni G, Alfieri L, Grignolo M, Ulivi P, Passardi A, Gallo G, Antonioli L, Di Virgilio F, Adinolfi E.   +13 more
europepmc   +1 more source

Inductive‐Associative Meta‐learning Pipeline with Human Cognitive Patterns for Unseen Drug‐Target Interaction Prediction

Advanced Science, EarlyView.
Predicting unseen drug‐target interactions is challenging. BioBridge presents an Inductive‐Associative pipeline inspired by scientists' workflow. It combines transferable binding principles, learned via multi‐level encoders and adversarial training, with insights from weakly related references through meta‐learning.
Xiaoqing Lian, Tianxu Lv, Jie Zhu, Shiyun Nie, Hang Fan, Guosheng Wu, Yunjun Ge, Hong Xu, Xiaoting Wang, Lihua Li, Xiangxiang Zeng, Xiang Pan   +11 more
wiley   +1 more source

Exploring Treatment Protocol Adherence and Variations in Paroxysmal Supraventricular Tachycardia in the Emergency Department: A Multi-Center Cohort Study. [PDF]

Med Sci (Basel)
Ku K, Healy J, Lee CA, Khan M, Chao KD, Hassan S, Tzeng CT, Hsieh YL, Shedd A, Bhakta T, Hassani D, Chou EH.   +11 more
europepmc   +1 more source

Volumetric Engineered 3D Drug Reservoir Against Diabetic Implant Infection via Cuproptosis‐Like Bacterial Death and Hunger‐Triggered Maintenance of Mitochondrial Integrity

Advanced Science, EarlyView.
This study provides a volumetric engineered 3D drug reservoir to combat diabetic implant infection. Cu‐doped quantum dots induce cuproptosis‐like bacterial death via metabolic collapse, while glucose oxidase triggers hunger‐triggered mitochondrial protection in host cells.
Dize Li, Hongrui Qin, Min Jiang, Hongjiang Wei, Hongyong Zhao, Ping Tang, Guangyu Jian, Henny C van der Mei, Tao Chen   +8 more
wiley   +1 more source

The flexibility of SABRE, a new quantitative receptor function model, when fitting challenging concentration-effect data. [PDF]

Front Pharmacol
Olah B, Tarjanyi V, Takacs B, Pluzsnyik E, Viczjan G, Ovari I, Szilvassy Z, Juhasz B, Zsuga J, Erdei T, Gesztelyi R.   +10 more
europepmc   +1 more source

m6A Reader hnRNPA2B1 Modulates Late Pachytene Progression in Male Meiosis Through Post‐Transcriptional Control

Advanced Science, EarlyView.
As an m6A reader, hnRNPA2B1 predominantly regulates specific transcripts (e.g., Ep400, Rrs1) that are essential for chromosome organization and remodeling in an m6A‐dependent manner. Furthermore, it is demonstrated to interact with factors involved in mRNA processing and translation. This dual functionality is pivotal for ensuring the proper occurrence
Lisha Yin, Yuting Zhang, Bingqian Zhang, Jin Zhang, Mengneng Xiong, Nan Jiang, Jinxin Xiao, Huihui Gao, Wenjing Xiong, Xiaoli Wang, Fengli Wang, Shuiqiao Yuan   +11 more
wiley   +1 more source

CXCL10-induced regulatory T cells and adenosine signaling promote immunosuppression and progression of epithelial ovarian cancer. [PDF]

Sci Rep
Lin AC, Moscarelli J, Zhu YL, Lin ZP, Ratner ES.   +4 more
europepmc   +1 more source