Results 341 to 350 of about 869,856 (392)

Engineering Adenine Deaminase TadA for Precise and PAM‐Flexible Point Mutagenesis and Gradient‐Tuning Endogenous Protein Design

Advanced Science, EarlyView.
Base editing enables precise nucleotide substitutions but limited by bystander editing. This study engineers plant base editors by fusing optimized TadA variants with PAM‐flexible SpRY nickase, enabling A‐to‐G, C‐to‐T, and dual‐base conversions in a highly condensed window (≤3 nucleotides). Additionally, TadDBE (TadA Dual‐Base Editor)‐mediated directed
Kangli Sun, Si Cheng, Nan Chai, Jianing Mi, Ruixiang Zhang, Qian Qian, Zhiye Zheng, Ke Chen, Dongchang Zeng, Xin Peng, Mengyuan Shen, Degui Zhou, Qinlong Zhu, Qi Liu, Jiantao Tan   +14 more
wiley   +1 more source

Adenosine transmission from hypothalamic tanycytes to AGRP/NPY neurons regulates energy homeostasis. [PDF]

Exp Mol Med
Kim N, Kim S, Park S, Kim EK.
europepmc   +1 more source

EGFR‐TKIs Induced DPP4 Drives Metabolic Reprogramming of Persister Cells in Lung Cancer

Advanced Science, EarlyView.
Drug‐tolerant persister (DTP) cells emerge early during EGFR‐TKI treatment, preceding the development of acquired resistance. Elevated DPP4 in DTP cells drives metabolic reprogramming and antioxidant adaptation, promoting cell survival under drug pressure.
Yuanzhou Zhang, Xiaojun Zhang, Xupeng Yang, Xingshi Chen, Yuehong Wang, Jingying Hu, Rui Liu, Xiaoying Luo   +7 more
wiley   +1 more source

Synthesis of Nucleoside Derivatives by Biomimetic Ester Migration. [PDF]

Chembiochem
Kurrle NJ, Seifert CJB, Hampel N, Rauch T, Thoma M, Parziale LV, Ebeling MSR, Berthold D, Trapp O.   +8 more
europepmc   +1 more source

A Pump‐Free, Hydraulic‐Amplification Oscillatory Microfluidic Device for Continuous Particle and Cell Manipulation

Advanced Science, EarlyView.
This study demonstrates a pump‐free, hydraulic‐amplification oscillatory microfluidic device, which generates oscillatory flows by deforming flexible microchannels through reciprocating finger pressing. The mechanism of elasto‐inertial focusing in the oscillatory flows is revealed, and early detection of drug‐treated platelet aggregates and rapid cell ...
Yong Liu, Mingyi Liang, Shanshan Xu, Sheng Yan   +3 more
wiley   +1 more source

Semaglutide and adenosine alleviate obesity-induced kidney injury, with observed modulation of the Txnip/NLRP3 pathway. [PDF]

Diabetol Metab Syndr
Wang S, Pan X, Liang R, Chen S.
europepmc   +1 more source

EXERCISE EFFECTS ON MUSCLE GLUCOSE UPTAKE AND INSULIN ACTION [PDF]

, 2008
Derave, Wim
core   +1 more source

AI‐Driven De Novo Design of Ultra Long‐Acting GLP‐1 Receptor Agonists

Advanced Science, EarlyView.
De novo GLP‐1RAs can be computationally designed to exhibit extended half‐life and superior efficacy compared to Semaglutide. Abstract Peptide drugs have revolutionized modern therapeutics, offering novel treatment avenues for various diseases. Nevertheless, low design efficacy, time consumption, and high cost still hinder peptide drug design and ...
Ting Wei, Jiating Ma, Xiaochen Cui, Jiahui Lin, Zhuoqi Zheng, Liu Cheng, Taiying Cui, Xiaoqian Lin, Junjie Zhu, Xuyang Ran, Xiaokun Hong, Luke Johnston, Zhangsheng Yu, Haifeng Chen   +13 more
wiley   +1 more source

Neuropharmacology adenosine A_2A receptor and glial glutamate transporter GLT-1 are synergistic targets to reduce brain hyperexcitability after traumatic brain injury in mice. [PDF]

Neuropharmacology
Alves M, Gerbatin R, Kalmeijer R, Fedele D, Engel T, Boison D.   +5 more
europepmc   +1 more source