Results 91 to 100 of about 1,574,376 (193)

Potential differences in receptor‐mediated G‐protein activation in postmortem human hippocampal membranes prepared from healthy controls and suicide victims

Neuropsychopharmacology Reports
Aim Postmortem brain studies offer enormous opportunities to study molecular mechanisms associated with suicide. In the present study, conventional [35S]GTPγS binding assay and its version‐up method ([35S]GTPγS binding/immunoprecipitation assay) were ...
Yuji Odagaki, Masakazu Kinoshita, Miklós Palkovits, Dasiel Oscar Borroto‐Escuela, Kjell Fuxe   +4 more
doaj   +1 more source

Lack of efficacy of a partial adenosine A1 receptor agonist in neuropathic pain models in mice. [PDF]

Purinergic Signal, 2021
Metzner K, Gross T, Balzulat A, Wack G, Lu R, Schmidtko A.   +5 more
europepmc   +1 more source

Adenosine A1 receptor ligands bind to α-synuclein: implications for α-synuclein misfolding and α-synucleinopathy in Parkinson's disease. [PDF]

Transl Neurodegener, 2022
Jakova E, Moutaoufik MT, Lee JS, Babu M, Cayabyab FS.   +4 more
europepmc   +1 more source

Target screening and optimization of candidate compounds for breast cancer treatment using bioinformatics and computational chemistry approaches

Frontiers in Pharmacology
ObjectivesThis study aimed to identify critical therapeutic targets and design potent antitumor compounds for breast cancer treatment through an integrated bioinformatics and computational chemistry approach.MethodsWe conducted initial screening and ...
Jian Xu, Xue Li, Yiduo Jia, Yiduo Jia
doaj   +1 more source

Adenosine A1 Receptor Deficiency Aggravates Extracellular Matrix Accumulation in Diabetic Nephropathy through Disturbance of Peritubular Microenvironment. [PDF]

J Diabetes Res, 2021
Tian D, Li J, Zou L, Lin M, Shi X, Hu Y, Lang J, Xu L, Ye W, Li X, Chen L.   +10 more
europepmc   +1 more source

The full activation mechanism of the adenosine A₁ receptor revealed by GaMD and Su-GaMD simulations. [PDF]

Proc Natl Acad Sci U S A, 2022
Li Y, Sun J, Li D, Lin J.
europepmc   +1 more source

Altered Heterosynaptic Plasticity Impairs Visual Discrimination Learning in Adenosine A1 Receptor Knock-Out Mice. [PDF]

J Neurosci, 2021
Chasse R, Malyshev A, Fitch RH, Volgushev M.   +3 more
europepmc   +1 more source

Discovery and Structure-Activity Relationship Studies of Novel Adenosine A₁ Receptor-Selective Agonists. [PDF]

J Med Chem, 2022
Preti B, Suchankova A, Deganutti G, Leuenberger M, Barkan K, Manulak I, Huang X, Carvalho S, Ladds G, Lochner M.   +9 more
europepmc   +1 more source

Adenosine Receptor A1 [PDF]

, 2020
openaire   +1 more source

Adenosine A1 Receptor Agonist (R-PIA) before Pilocarpine Modulates Pro- and Anti-Apoptotic Factors in an Animal Model of Epilepsy. [PDF]

Pharmaceuticals (Basel), 2021
Persike DS, Puccinelli RPA, Fernandes MJDS.   +2 more
europepmc   +1 more source