Results 111 to 120 of about 1,637,170 (273)

Investigation of adenosine A1 receptor-mediated β-arrestin 2 recruitment using a split-luciferase assay. [PDF]

Front Pharmacol, 2023
Saecker L, Häberlein H, Franken S.
europepmc   +1 more source

Functional Roles of Adenosine A2B and A3 Receptor Subtypes in the Bladder of Male Rats With A2B Receptor Deletion or Bladder Outlet Obstruction

Neurourology and Urodynamics, EarlyView.
ABSTRACT Purpose To investigate the adenosine receptor (AR) mechanism underlying bladder outlet obstruction (BOO)‐related bladder dysfunction, we examined the expression level of AR subtypes in bladder tissues, and the effects of AR subtypes A2B & A3 modulation on bladder activity using male BOO rats, and Dahl rats with A2B receptor deletion. Materials
Masahiro Kurobe, Ei‐ichiro Takaoka, Kanako Matsuoka, Shingo Kimura, Anne M. Robertson, Edwin K. Jackson, Lori A. Birder, Minoru Miyazato, Naoki Yoshimura   +8 more
wiley   +1 more source

Cloning and functional characterization of a human A1 adenosine receptor.

, 1992
A human brain hippocampus cDNA library was screened by hybridization with a dog A1 adenosine receptor cDNA probe. Sequencing of the resulting clones identified a 978 residue open reading frame encoding a 326 amino acid polypeptide showing 95.7 ...
Libert, Frédérick, Czernilofsky, A, Dumont, Jacques, Lefort, Anne, Ensinger, H A, Mendla, K D, Vassart, Gilbert, Van Sande, Jacqueline   +7 more
core   +1 more source

Affinity and selectivity of tecadenoson, 2-chloro-tecadenoson and 2’-C-methyl analogues at bovine and pig A1 adenosine receptor

, 2005
Adenosine A1 receptor agonists have a great interest as neuroprotective agents for the treatment of glutamate-related neurodegenerative disorders and as antilipolytic agents.
PASQUALINI M., COSTA B., FRANCHETTI, Palmarisa, KLOTZ K., CAPPELLACCI, Loredana, VITA, PATRIZIA, PETRELLI, Riccardo, MARTINI C., SPINETTI F., LAVECCHIA A., GRIFANTINI, Mario   +10 more
core   +1 more source

Protective Potentials of Natural Products Against Vascular Dementia: A Comprehensive Review of Experimental Studies

Phytotherapy Research, EarlyView.
ABSTRACT Vascular dementia (VaD), accounting for up to 20% of dementia cases globally, is primarily driven by chronic cerebral hypoperfusion (CCH), which leads to progressive cognitive impairment. Despite the increasing prevalence of VaD, effective treatments remain limited.
Jung‐Hoon Kim, Yongtaek Oh, Suin Cho
wiley   +1 more source

N6-substituted C5′-modified adenosines as A1 adenosine receptor agonists

, 2008
N6-substituted C5′-modified adenosines as A1 adenosine receptor ...
S Baker (9861626), Sally Hutchinson (13051977), Trent Ashton (13097196), Peter Scammells (13051092)   +3 more
core  

Ex Vivo Feedback Control of Neurotransmission Using a Photocaged Adenosine A1 Receptor Agonist. [PDF]

Int J Mol Sci, 2022
Craey E, Hulpia F, Spanoghe J, Manzella S, Larsen LE, Sprengers M, De Bundel D, Smolders I, Carrette E, Delbeke J, Vonck K, Boon P, Van Calenbergh S, Wadman WJ, Raedt R.   +14 more
europepmc   +1 more source

Notoginsenoside R2 Antagonizes Renal Interstitial Fibrosis by Regulating Fatty Acid Oxidation via the CASP2/ALDH3A1 Axis

Phytotherapy Research, EarlyView.
Proposed mechanism by which notoginsenoside R2 (NGR2) attenuates renal interstitial fibrosis. In injured renal tubular epithelial cells, CASP2 downregulation and enhanced ubiquitin‐dependent degradation of ALDH3A1 disrupt mitochondria‐associated endoplasmic reticulum membranes (MAMs) and impair fatty acid oxidation (FAO), leading to lipid accumulation ...
Guanting Chen, Tao Li, Zhenzhen Wang, Hao Zhao, Xiaoxia Xun, Yijiao Wang, Shiyuan Jiang, Qing Zhang, Weiwei Sun, Kang Yang, Yaoxian Wang   +10 more
wiley   +1 more source

Heteromerización de receptores de adenosina A2A, dopamina D2 y cannabinoides CB1. Implicaciones farmacológicas y funcionales. [PDF]

, 2007
[spa] La visión de los receptores acoplados a proteína G ha evolucionado en los últimos años. Clásicamente se consideraban unidades individuales capaces de producir una señal intracelular; actualmente, está aceptado que estas proteínas de membrana pueden
Carriba Domínguez, Paulina
core   +2 more sources

Cancer-Related Somatic Mutations in Transmembrane Helices Alter Adenosine A1 Receptor Pharmacology. [PDF]

Molecules, 2022
Wang X, Jespers W, Wolff KAN, Buytelaar J, IJzerman AP, van Westen GJP, Heitman LH.   +6 more
europepmc   +1 more source