Results 131 to 140 of about 1,637,170 (273)

The potential for biased signalling in the P2Y receptor family of GPCRs

British Journal of Pharmacology, EarlyView.
The purinergic receptor family is primarily activated by nucleotides, and contains members of both the G protein coupled‐receptor (GPCR) superfamily (P1 and P2Y) and ligand‐gated ion channels (P2X). The P2Y receptors are widely expressed in the human body, and given the ubiquitous nature of nucleotides, purinergic signalling is involved with a plethora
Claudia M. Sisk, Simon Pitchford, Graham Ladds   +2 more
wiley   +1 more source

Efeito da acupuntura no modelo de dor pós-operatória em camundongos: investigação do sistema adenosinérgico utilizando a farmacopuntura [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em NeurociênciasA acupuntura é uma modalidade terapêutica comumente utilizada no tratamento da dor.
Moré, Ari Ojeda Ocampo
core  

Repetitive stimulation of adenosine A1 receptors in vivo:Changes in receptor numbers, G-proteins and A1 receptor agonist-induced hypothermia

, 2008
Adenosine is an important neuromodulator and neuroprotective molecule, which is produced in the brain as a function of neuronal activity, coupling energy expenditure to energy supply. Under conditions of increased need and reduced availability of energy,
Roman, Viktor, Luiten, Paul G. M., Meerlo, Peter, Meerlo, Peter; id_orcid, Keijser, Johannes   +4 more
core   +1 more source

Adenosine A1 receptor (ADORA1) [PDF]

Science-Business eXchange, 2009
  +6 more sources

Clues from a missense mutation of the adenosine A₁ receptor gene associated with early-onset Parkinson's disease. [PDF]

Neural Regen Res, 2023
Ferré S, Pardo L, Ciruela F.
europepmc   +1 more source

Impact of incretin analogues on lipid and lipoprotein metabolism in obesity and diabetes

British Journal of Pharmacology, EarlyView.
Abstract Incretin‐based therapies have gained momentum as a key strategy for reducing cardiovascular risk in individuals with obesity and/or type 2 diabetes (T2D). It remains unclear whether the cardiovascular benefits reflect a direct reduction in atherogenic lipoproteins—namely, low‐density lipoproteins (LDL), very low‐density lipoproteins (VLDL) and
Andrea Baragetti, Giuseppe Danilo Norata
wiley   +1 more source

Age-related changes in A1 adenosine receptor mediated bradycardia

, 2000
The impact of age on functional sensitivity to A1-adenosine receptor activation was studied in Langendorff-perfused hearts from young (1-2 mo) and old (12-18 mo) male Wistar rats.
Headrick, JP, Rose'meyer, RB, Hinschen, AK   +2 more
core  

Potential differences in receptor‐mediated G‐protein activation in postmortem human hippocampal membranes prepared from healthy controls and suicide victims

Neuropsychopharmacology Reports
Aim Postmortem brain studies offer enormous opportunities to study molecular mechanisms associated with suicide. In the present study, conventional [35S]GTPγS binding assay and its version‐up method ([35S]GTPγS binding/immunoprecipitation assay) were ...
Yuji Odagaki, Masakazu Kinoshita, Miklós Palkovits, Dasiel Oscar Borroto‐Escuela, Kjell Fuxe   +4 more
doaj   +1 more source

Lack of efficacy of a partial adenosine A1 receptor agonist in neuropathic pain models in mice. [PDF]

Purinergic Signal, 2021
Metzner K, Gross T, Balzulat A, Wack G, Lu R, Schmidtko A.   +5 more
europepmc   +1 more source

Peripheral targets for neuropathic pain

British Journal of Pharmacology, EarlyView.
Neuropathic pain represents a significant clinical challenge, with still limited pharmacological approaches to symptomatic relief. This review focuses on molecular targets implicated in neuropathic pain, particularly those involved in peripheral mechanisms. Using the IUPHAR/BPS database of biological targets, their occurrence together with ‘neuropathic
Amirhossein Afsharipour, Cosmin I. Ciotu, Felix J. Resch, Michael J. M. Fischer   +3 more
wiley   +1 more source