Results 151 to 160 of about 1,637,170 (273)

Discovery and Structure-Activity Relationship Studies of Novel Adenosine A₁ Receptor-Selective Agonists. [PDF]

J Med Chem, 2022
Preti B, Suchankova A, Deganutti G, Leuenberger M, Barkan K, Manulak I, Huang X, Carvalho S, Ladds G, Lochner M.   +9 more
europepmc   +1 more source

Adenosine Receptor A1 [PDF]

, 2020
openaire   +1 more source

How I Investigate Bleeding Disorders of Unknown Cause: Current Diagnostic Pathways and Gaps in Laboratory Investigation

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Bleeding disorder of unknown cause (BDUC) constitutes the largest group of patients presenting with a mild‐to‐moderate bleeding tendency in tertiary care settings. Their clinical bleeding phenotype is characterized by mucocutaneous bleeding, as well as bleeding following surgical challenges or childbirth, and is associated with impaired health‐
Dino Mehic, Faris Karaselimovic, Tim Dreier, Johanna Gebhart   +3 more
wiley   +1 more source

Adenosine A1 Receptor Agonist (R-PIA) before Pilocarpine Modulates Pro- and Anti-Apoptotic Factors in an Animal Model of Epilepsy. [PDF]

Pharmaceuticals (Basel), 2021
Persike DS, Puccinelli RPA, Fernandes MJDS.   +2 more
europepmc   +1 more source

Characterization of AF Recurrence and Substrate Health by Electrographic Flow (EGF) Consistency in EGF Mapping

Journal of Cardiovascular Electrophysiology, EarlyView.
ABSTRACT Background Electrographic flow (EGF) mapping is an FDA 510(k)‐cleared method for visualizing atrial activation wavefronts in atrial fibrillation (AF). Its clinical efficacy in detecting AF sources was demonstrated in the FLOW‐AF randomized controlled trial, and the underlying machine learning strategy used to develop and refine EGF source ...
Steven Castellano, Marloes Jansen, Lucas V. A. Boersma, Marisa van der Graaf, Melissa H. Kong, Kostiantyn Ahapov, Philip Haeusser, Moritoshi Funasako, John D. Hummel, Wilber W. Su   +9 more
wiley   +1 more source

Activation of hepatic adenosine A1 receptor ameliorates MASH via inhibiting SREBPs maturation. [PDF]

Cell Rep Med
Zhu W, Hong Y, Tong Z, He X, Li Y, Wang H, Gao X, Song P, Zhang X, Wu X, Tan Z, Huang W, Liu Z, Bao Y, Ma J, Zheng N, Xie C, Ke X, Zhou W, Jia W, Li M, Zhong J, Sheng L, Li H.   +23 more
europepmc   +2 more sources

Neuronal Adenosine A₁ Receptor is Critical for Olfactory Function but Unable to Attenuate Olfactory Dysfunction in Neuroinflammation. [PDF]

Front Cell Neurosci, 2022
Schubert C, Schulz K, Träger S, Plath AL, Omriouate A, Rosenkranz SC, Morellini F, Friese MA, Hirnet D.   +8 more
europepmc   +1 more source

An OsSK12/13‐OsERF60‐OsHsfA2c module regulates heat stress tolerance in rice

Journal of Integrative Plant Biology, EarlyView.
The heat‐induced GSK3‐like kinases OsSK12 and OsSK13 phosphorylate and stabilize the transcription factor OsERF60, which activates the expression of downstream genes including the heat shock factor gene OsHsfA2c. This regulatory module governs heat‐responsive gene induction, representing a mechanistic target for enhancing crop resilience under climate ...
Juan Gao, Zi‐Wei Yao, Zhi‐Ping Deng, Jing‐Jing Wang, Dong‐Jie Zhu, Dai‐Xi Yue, Hai‐Ping Lu, Jian‐Xiang Liu   +7 more
wiley   +1 more source

Selective activation of Gαob by an adenosine A₁ receptor agonist elicits analgesia without cardiorespiratory depression. [PDF]

Nat Commun, 2022
Wall MJ, Hill E, Huckstepp R, Barkan K, Deganutti G, Leuenberger M, Preti B, Winfield I, Carvalho S, Suchankova A, Wei H, Safitri D, Huang X, Imlach W, La Mache C, Dean E, Hume C, Hayward S, Oliver J, Zhao FY, Spanswick D, Reynolds CA, Lochner M, Ladds G, Frenguelli BG.   +24 more
europepmc   +1 more source

Prolonged in vitro exposure of rat brain slices to adenosine analogues: selective desensitization of adenosine A1 but not A2 receptors

, 1992
Agonist-induced desensitization of adenosine A1 and A2 receptors was studied in rat striatum slices maintained in carbo-oxygenated Krebs buffer. Slices were exposed to adenosine analogues (either cyclo-pentyl-adenosine or N-ethyl-carboxamido-adenosine ...
Abbracchio MP, Cattabeni F, Fogliatto G, Rovati GE, Paoletti AM   +4 more
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