Results 161 to 170 of about 238,585 (333)

The Ever‐Expanding Influence of the Endothelial Nitric Oxide Synthase

open access: yesBasic &Clinical Pharmacology &Toxicology, Volume 136, Issue 5, May 2025.
ABSTRACT Nitric oxide (NO) generated by the endothelial NO synthase (eNOS) plays an essential role in the maintenance of vascular homeostasis and the prevention of vascular inflammation. There are a myriad of mechanisms that regulate the activity of the enzyme that may prove to represent interesting therapeutic opportunities.
Riham Rafea   +2 more
wiley   +1 more source

The Effects of Metformin on the Glucose Metabolism in Lactobacillus acidophilus [PDF]

open access: yes, 2013
Metformin (1,1-dimethylbiguanide) is an anti-hyperglycemic agent that is commonly used in the oral treatment of Type 2 Diabetes Mellitus. Phenformin (phenethylbiguanide) is its structural analog.
Amatya, Neha   +3 more
core   +1 more source

36 degree step size of proton-driven c-ring rotation in FoF1-ATP synthase [PDF]

open access: yesarXiv, 2009
Synthesis of the biological "energy currency molecule" adenosine triphosphate ATP is accomplished by FoF1-ATP synthase. In the plasma membrane of Escherichia coli, proton-driven rotation of a ring of 10 c subunits in the Fo motor powers catalysis in the F1 motor. While F1 uses 120 degree stepping, Fo models predict a step-by-step rotation of c subunits
arxiv  

Chemical Proteomics Reveals Human Off‐Targets of Fluoroquinolone Induced Mitochondrial Toxicity

open access: yesAngewandte Chemie International Edition, Volume 64, Issue 18, April 25, 2025.
A schematic overview of the adverse effects of Ciprofloxacin related to mitochondrial toxicity. AIFM1 plays a role in the MIA40‐mediated import into the IMS and oxidative folding of nuclear‐encoded proteins, including ETC complexes I and IV subunits. Ciprofloxacin disrupts the IMS import machinery, impairing ETC function.
Till Reinhardt   +14 more
wiley   +1 more source

Diagnostic value of serum Adenosine deaminase and its isoenzymes in the diagnosis of pulmonary tuberculosis

open access: yesمجله دانشگاه علوم پزشکی گرگان, 2008
Background & Objective: Adenosine deaminase is an enzyme which catalyses adenosine to Inosine. The determination of adenosine deaminase in body fluids is important for the diagnosis of tuberculosis.
Hamid Reza Joshaghani   +3 more
doaj  

Role of Sulphydryl Groups in Adenosine Deaminase [PDF]

open access: bronze, 1967
G. Ronca, C. Bauer, Carlo Rossi
openalex   +1 more source

RNA editing by ADAR1 leads to context-dependent transcriptome-wide changes in RNA secondary structure

open access: yesNature Communications, 2017
Adenosine deaminase acting on RNA 1 (ADAR1) edits adenosine to inosine. Here the authors, using parallel analysis of RNA secondary structure sequencing, provide evidence that ADAR1 induces sequence-context-dependent RNA secondary structures changes ...
Oz Solomon   +16 more
doaj   +1 more source

Development of Carbon-Fiber Electrodes Modified for Electrochemical ATP Detection [PDF]

open access: yesarXiv, 2018
Adenosine triphosphate (ATP) is a highly energetic molecule used as a coenzyme in the transfer of chemical energy required for the continuation of cellular metabolism. In addition, extracellular ATP has an important role in cell-to-cell communication in immune, nervous and vascular systems.
arxiv  

Quantitative Immunoassay of Adenosine Deaminase in Combined Immunodeficiency Disease [PDF]

open access: bronze, 1977
Dennis A. Carson   +2 more
openalex   +1 more source

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