Results 11 to 20 of about 215,850 (301)

Adenosine deaminase deficiency: a review [PDF]

Orphanet Journal of Rare Diseases, 2018
Adenosine deaminase (ADA) deficiency leads to an accumulation of toxic purine degradation by-products, most potently affecting lymphocytes, leading to adenosine deaminase-deficient severe combined immunodeficiency.
Aisling M. Flinn, Andrew R. Gennery
doaj   +5 more sources

Deficiency of Adenosine Deaminase 2 [PDF]

Turkish Journal of Hematology
Adenosine deaminase 2 (ADA2) deficiency is an autosomal recessively inherited autoinflammatory disorder caused by loss-of-function mutations in the ADA2 gene. Although the pathogenesis involves the triggering of a proinflammatory cascade due to increased
Çağrı Coşkun, Şule Ünal
doaj   +4 more sources

Adenosine-Metabolizing Enzymes, Adenosine Kinase and Adenosine Deaminase, in Cancer

Biomolecules, 2022
The immunosuppressive effect of adenosine in the microenvironment of a tumor is well established. Presently, researchers are developing approaches in immune therapy that target inhibition of adenosine or its signaling such as CD39 or CD73 inhibiting ...
Galina Zhulai, Eugenia Oleinik, Mikhail Shibaev, Kirill Ignatev   +3 more
doaj   +2 more sources

Deficiency of adenosine deaminase 2 leading to recurrent Hodgkin lymphoma: A case report [PDF]

SAGE Open Medical Case Reports
Deficiency of adenosine deaminase 2 is a rare monogenic multi-organ disease of children and less often adults resulting from mutations in the adenosine deaminase 2 gene.
Anas Manhal, Mahmoud M Qouqas, Ahmad Fasfoos, Jamal Abdullah, Shaban Abudaowd, Obada Amro, Layth Al-Karaja, Laith Alamlih   +7 more
doaj   +2 more sources

Adenosine deaminase acting on RNA 1 (ADAR1) as crucial regulators in cardiovascular diseases: structures, pathogenesis, and potential therapeutic approach

Frontiers in Pharmacology, 2023
Cardiovascular diseases (CVDs) are a group of diseases that have a major impact on global health and are the leading cause of death. A large number of chemical base modifications in ribonucleic acid (RNA) are associated with cardiovascular diseases.
Jieying Chen, Junyan Jin, Junyan Jin, Jun Jiang, Jun Jiang, Yaping Wang, Yaping Wang   +6 more
doaj   +1 more source

Autologous Ex Vivo Lentiviral Gene Therapy for Adenosine Deaminase Deficiency.

New England Journal of Medicine, 2021
BACKGROUND Severe combined immunodeficiency due to adenosine deaminase (ADA) deficiency (ADA-SCID) is a rare and life-threatening primary immunodeficiency.
D. Kohn, C. Booth, K. Shaw, J. Xu-Bayford, E. Garabedian, V. Trevisan, D. A. Carbonaro-Sarracino, Kajal Soni, Dayna Terrazas, Katie Snell, A. Ikeda, D. León-Rico, T. Moore, K. Buckland, Ami J. Shah, K. Gilmour, Satiro N De Oliveira, C. Rivat, G. Crooks, N. Izotova, J. Tse, S. Adams, S. Shupien, H. Ricketts, A. Davila, Chilenwa Uzowuru, A. Icreverzi, Provaboti Barman, Beatriz Campo Fernandez, R. Hollis, M. Coronel, Allen Yu, Krista M. Chun, Christian E. Casas, Ruixue Zhang, S. Arduini, F. Lynn, M. Kudari, A. Spezzi, M. Zahn, Rene Heimke, Ivan Labik, R. Parrott, R. Buckley, L. Reeves, K. Cornetta, R. Sokolic, M. Hershfield, M. Schmidt, F. Candotti, H. Malech, A. Thrasher, H. Gaspar   +52 more
semanticscholar   +1 more source

Serum Adenosine Deaminase as a Useful Marker to Estimate Coronary Artery Calcification in Type 2 Diabetes Mellitus Patients

Clinical and Applied Thrombosis/Hemostasis, 2021
We investigated the association between serum adenosine deaminase and coronary artery calcification (CAC) in type 2 diabetes mellitus (T2DM) patients.
Ming Yu M.Med, Hanyun Zhou M.Med, Qingan Li MB, Juan Ding MB, Hongxia Shuai PhD, Ji Zhang MB   +5 more
doaj   +1 more source

Adenosine deaminase as a marker for the severity of infectious mononucleosis secondary to EBV in children

BMC Infectious Diseases, 2022
Background Infectious mononucleosis, a common disease in children and young adults, is often accompanied by elevated transaminase levels and rarely, liver failure.
Ting Shi, Jungen Li, Yuzhu Miao, Linlin Huang, Jianmei Tian   +4 more
doaj   +1 more source

Adenosine Deaminase Deficiency in Adults [PDF]

Blood, 1997
AbstractAdenosine deaminase (ADA) deficiency typically causes severe combined immunodeficiency (SCID) in infants. We report metabolic, immunologic, and genetic findings in two ADA-deficient adults with distinct phenotypes. Patient no. 1 (39 years of age) had combined immunodeficiency. She had frequent infections, lymphopenia, and recurrent hepatitis as
Ozsahin, H, Arredondo-Vega, F X, Santisteban, I, Fuhrer, H, Tuchschmid, P, Jochum, W, Aguzzi, A, Lederman, H M, Fleischman, A, Winkelstein, J A, Seger, R A, Hershfield, M S   +11 more
openaire   +4 more sources

Adenosine deaminase deficiency

Atlas of Inherited Metabolic Diseases, 2020
Adenosine deaminase (ADA) deficiency is an inherited disorder that damages the immune system and causes severe combined immunodeficiency (SCID). People with SCID lack virtually all immune protection from bacteria, viruses, and fungi.
Larry W. Moreland
semanticscholar   +1 more source