Results 11 to 20 of about 54,436 (239)

Diagnostic Implications and Correlates of Plasma Adenosine Deaminase 2 Activity and ADA2 Variants. [PDF]

Arthritis Rheumatol
Objective Deficiency of adenosine deaminase 2 (DADA2) is a monogenic autoinflammatory disease manifested as polyarteritis nodosa, stroke, and bone marrow failure. Leveraging an international cohort of 200 DADA2 cases, we aimed to characterize the diagnostic utility of a plasma ADA2 enzyme activity assay and understand the implications of residual ADA2 ...
Yue J, LeSon CE, Rimland CA, Brodeur K, Weng R, Hsu EE, Lam MT, Meyer M, Okada S, Hsu ALD, Alhezam MA, Perron MM, Halyabar O, Dedeoglu F, Nigrovic PA, Shimamura A, Rowe RG, Cooper MA, Vogel TP, Gillispie-Taylor M, Peterson R, Lin C, Nowicki KD, Dollerschell K, Nakano TA, Labrosse R, Cochino AV, Ioan A, Mendonca LO, Barros SF, Kalil J, Perez-Rojas J, Diaz-Kuan A, Sobel ES, Moussa T, Lee SSM, Koh LW, Khan A, Sutnga S, Khubchandani R, Shoman W, El Chazli Y, Pinto B, Kavadichanda C, Abraham RS, Sun X, Zhou Q, Naidu G, Sharma A, Esperanzate C, Kastner DL, Aksentijevich I, Kelly SJ, Hershfield M, Tarrant TK, Lee PY.   +55 more
europepmc   +2 more sources

The ADA*2 allele of the adenosine deaminase gene (20q13.11) and recurrent spontaneous abortions: an age-dependent association

Clinics, 2011
OBJECTIVE: Adenosine deaminase acts on adenosine and deoxyadenosine metabolism and modulates the immune response. The adenosine deaminase G22A polymorphism (20q.11.33) influences the level of adenosine deaminase enzyme expression, which seems to play a ...
Daniela Prudente Teixeira Nunes, Lígia Cosentino Junqueira Franco Spegiorin, Cinara Cássia Brandão de Mattos, Antonio Helio Oliani, Denise Cristina Mós Vaz-Oliani, Luiz Carlos de Mattos   +5 more
doaj   +1 more source

Serum adenosine deaminase, catalase and carbonic anhydrase activities in patients with bladder cancer

Clinics, 2012
OBJECTIVES: The relationship between adenosine deaminase and various cancers has been investigated in several studies. However, serum adenosine deaminase activity and carbonic anhydrase and catalase activities in patients with bladder cancer have not ...
Necip Pirinççi, Ilhan Geçit, Mustafa Güneş, Mehmet Bilgehan Yüksel, Mehmet Kaba, Serhat Tanık, Halit Demir, Mehmet Aslan   +7 more
doaj   +1 more source

Biosensor measurement of purine release from cerebellar cultures and slices [PDF]

, 2010
We have previously described an action-potential and Ca2+-dependent form of adenosine release in the molecular layer of cerebellar slices. The most likely source of the adenosine is the parallel fibres, the axons of granule cells. Using microelectrode
Wall, Mark J., Eason, Robert, Dale, Nicholas   +2 more
core   +2 more sources

A novel mutation in the ADA gene causing severe combined immunodeficiency in an Arab patient: a case report

Journal of Medical Case Reports, 2009
Introduction About 20% of the cases of human severe combined immunodeficiency are the result of the child being homozygous for defective genes encoding the enzyme adenosine deaminase.
Hellani Ali, Almassri Nidal, Abu-Amero Khaled K   +2 more
doaj   +1 more source

Metabolic Aspects of Adenosine Functions in the Brain

Frontiers in Pharmacology, 2021
Adenosine, acting both through G-protein coupled adenosine receptors and intracellularly, plays a complex role in multiple physiological and pathophysiological processes by modulating neuronal plasticity, astrocytic activity, learning and memory, motor ...
Mercedes Garcia-Gil, Mercedes Garcia-Gil, Marcella Camici, Simone Allegrini, Rossana Pesi, Maria Grazia Tozzi   +5 more
doaj   +1 more source

DNA editing in DNA/RNA hybrids by adenosine deaminases that act on RNA. [PDF]

, 2017
Adenosine deaminases that act on RNA (ADARs) carry out adenosine (A) to inosine (I) editing reactions with a known requirement for duplex RNA. Here, we show that ADARs also react with DNA/RNA hybrid duplexes.
Beal, Peter A, Lorenzo, Claire, Zheng, Yuxuan   +2 more
core   +1 more source

Pleural effusion adenosine deaminase: a candidate biomarker to discriminate between Gram-negative and Gram-positive bacterial infections of the pleural space

Clinics, 2016
OBJECTIVES: Delay in the treatment of pleural infection may contribute to its high mortality. In this retrospective study, we aimed to evaluate the diagnostic accuracy of pleural adenosine deaminase in discrimination between Gram-negative and Gram ...
Ruolin Li, Junli Wang, Xinfeng Wang, Maoshui Wang   +3 more
doaj   +1 more source

Adenosine Deaminase Deficiency in Adults [PDF]

Blood, 1997
AbstractAdenosine deaminase (ADA) deficiency typically causes severe combined immunodeficiency (SCID) in infants. We report metabolic, immunologic, and genetic findings in two ADA-deficient adults with distinct phenotypes. Patient no. 1 (39 years of age) had combined immunodeficiency. She had frequent infections, lymphopenia, and recurrent hepatitis as
Ozsahin, H, Arredondo-Vega, F X, Santisteban, I, Fuhrer, H, Tuchschmid, P, Jochum, W, Aguzzi, A, Lederman, H M, Fleischman, A, Winkelstein, J A, Seger, R A, Hershfield, M S   +11 more
openaire   +3 more sources

Impulse oscillometry identifies peripheral airway dysfunction in children with adenosine deaminase deficiency. [PDF]

, 2015
Adenosine deaminase-deficient severe combined immunodeficiency (ADA-SCID) is characterized by impaired T-, B- and NK-cell function. Affected children, in addition to early onset of infections, manifest non-immunologic symptoms including pulmonary ...
Candotti, Fabio, Hershfield, Michael S, Kohn, Donald B, Komarow, Hirsh D, Metcalfe, Dean D, Sokolic, Robert, Young, Michael   +6 more
core   +2 more sources