Results 21 to 30 of about 238,585 (333)

Neurogenetics of the Human Adenosine Receptor Genes: Genetic Structures and Involvement in Brain Diseases [PDF]

Journal of Caffeine and Adenosine Research, New Rochelle, N.Y. : Mary Ann Liebert, Inc., [2018]-, 2019, 9 (3), pp.73-88, 2020
Adenosine receptors are G-protein-coupled receptors involved in a wide range of physiological and pathological phenomena in most mammalian systems. All four receptors are widely expressed in the central nervous system, where they modulate neurotransmitter release and neuronal plasticity. A large number of gene association studies have shown that common
arxiv   +1 more source

Asymmetric dimerization of adenosine deaminase acting on RNA facilitates substrate recognition

Nucleic Acids Research, 2020
Adenosine deaminases acting on RNA (ADARs) are enzymes that convert adenosine to inosine in duplex RNA, a modification that exhibits a multitude of effects on RNA structure and function.
A. Thuy-Boun, Justin M. Thomas, Herra L. Grajo, Cody M. Palumbo, Sehee Park, L. T. Nguyen, A. Fisher, P. Beal   +7 more
semanticscholar   +1 more source

CRISPR applications for Duchenne muscular dystrophy: From animal models to potential therapies

WIREs Mechanisms of Disease, Volume 15, Issue 1, January/February 2023., 2023
CRISPR‐Cas9 gene‐editing technology enables the rapid generation of animal models for Duchenne muscular dystrophy research and has potential to be developed as CRISPR therapy for the long lasting genetic correction of causal mutations. Abstract CRISPR gene‐editing technology creates precise and permanent modifications to DNA.
Yu C. J. Chey, Jayshen Arudkumar, Annemieke Aartsma‐Rus, Fatwa Adikusuma, Paul Q. Thomas   +4 more
wiley   +1 more source

Neurodegeneration in multiple sclerosis

WIREs Mechanisms of Disease, Volume 15, Issue 1, January/February 2023., 2023
Chronic demyelination results in impaired axon metabolism and function, ultimately leading to progressive neurological decline. Neuroprotective strategies aim to protect axons from inflammatory‐mediated destruction, thereby improving axonal integrity and clinical disability (Image created in BioRender.com).
Gabrielle M. Mey, Kedar R. Mahajan, Tara M. DeSilva   +2 more
wiley   +1 more source

Expanding a fluorescent RNA alphabet: synthesis, photophysics and utility of isothiazole-derived purine nucleoside surrogates. [PDF]

, 2017
A series of emissive ribonucleoside purine mimics, all comprised of an isothiazolo[4,3-d]pyrimidine core, was prepared using a divergent pathway involving a key Thorpe-Ziegler cyclization.
Fin, Andrea, Rovira, Alexander R, Tor, Yitzhak   +2 more
core   +1 more source

Metabolic Aspects of Adenosine Functions in the Brain

Frontiers in Pharmacology, 2021
Adenosine, acting both through G-protein coupled adenosine receptors and intracellularly, plays a complex role in multiple physiological and pathophysiological processes by modulating neuronal plasticity, astrocytic activity, learning and memory, motor ...
Mercedes Garcia-Gil, Mercedes Garcia-Gil, Marcella Camici, Simone Allegrini, Rossana Pesi, Maria Grazia Tozzi   +5 more
doaj   +1 more source

Break down the barriers of auto‐inflammation: How to deal with a monogenic auto‐inflammatory disease and immuno‐haematological features in 2022?

Immunology, Volume 168, Issue 1, Page 1-17, January 2023., 2023
In the past few years, the spectrum of monogenic systemic auto‐inflammatory diseases has widely expanded beyond the typical recurrent fever. Immuno‐haematological features, as cytopenias, hypogammaglobulinemia, hypereosinophilia, lymphoproliferation and immunodeficiency, have been described in association of several MSAID.
Hélène Vergneault, Capucine Picard, Sophie Georgin‐Lavialle   +2 more
wiley   +1 more source

Adenosine deaminase as marker of insulin resistance [PDF]

, 2016
Background:Type-2 diabetes complications contribute to increased morbidity and mortality and hence early diagnosis and control of diabetes is necessary. Adenosine deaminase activity is present in almost all human tissues, but the highest levels are found
L. S., Adarsh, Menon, Vineetha Bharathan, Muthiah, Bhanukumar, Peddi, Naveen Krishna   +3 more
core   +3 more sources

A novel mutation in the ADA gene causing severe combined immunodeficiency in an Arab patient: a case report

Journal of Medical Case Reports, 2009
Introduction About 20% of the cases of human severe combined immunodeficiency are the result of the child being homozygous for defective genes encoding the enzyme adenosine deaminase.
Hellani Ali, Almassri Nidal, Abu-Amero Khaled K   +2 more
doaj   +1 more source

Adenosine Deaminase 2 Deficiency

Definitions, 2020
Inflammation is a normal immune system response to injury and foreign invaders (such as bacteria). However, ADA2 deficiency causes abnormal, unprovoked inflammation that can damage the body's tissues and organs, particularly blood vessels. ( Inflammation

semanticscholar   +1 more source