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Human adenosine deaminase [PDF]

Biochimica et Biophysica Acta (BBA) - Protein Structure, 1979
In many human tissues adenosine deaminase exists as a large molecular weight complex (large form) composed of adenosine deaminase and an adenosine deaminase binding protein. The molar ratio of adenosine deaminase to binding protein in this large form complex appears to be 2:1, respectively, based on several observations.
Daddona, Peter E., Kelley, William N.
openaire   +4 more sources

Deficiency of Adenosine Deaminase 2 in Adults and Children: Experience From India

Arthritis & Rheumatology, 2020
Deficiency of adenosine deaminase 2 (DADA2) is a potentially fatal monogenic syndrome characterized by variable manifestations of systemic vasculitis, bone marrow failure, and immunodeficiency.
Aman Sharma, G. Naidu, Vikas Sharma, S. Jha, Aaadhar Dhooria, V. Dhir, P. Bhatia, Vishal Sharma, S. Bhattad, Chengappa, Vikas Gupta, D. Misra, P. P. Chavan, Sourabh Malaviya, Rajkiran Dudam, Banwari Sharma, Sathish Kumar, R. Bhojwani, Pankaj Gupta, V. Agarwal, K. Sharma, M. Singhal, M. Rathi, R. Nada, R. Minz, V. Chaturvedi, A. Aggarwal, R. Handa, A. Grossi, M. Gattorno, Zhengping Huang, Jun Wang, R. Jois, V. Negi, R. Khubchandani, Sanjay Jain, J. Aróstegui, E. Chambers, M. Hershfield, I. Aksentijevich, Qing Zhou, Pui Y. Lee   +41 more
semanticscholar   +1 more source

Role of serum and pleural adenosine deaminase activity compared to pleural fluid analysis in patients with pleural effusion of various etiology

MRIMS Journal of Health Sciences, 2023
Background: Numerous tests are available for determining the cause of exudate, but all these tests lack sensitivity and specificity, and they are not generally available.
Mubasheer Ali, Prashant Janjal, M V Raghavendra Rao   +2 more
doaj   +1 more source

Therapeutic Perspectives of Adenosine Deaminase Inhibition in Cardiovascular Diseases

Molecules, 2020
Adenosine deaminase (ADA) is an enzyme of purine metabolism that irreversibly converts adenosine to inosine or 2′deoxyadenosine to 2′deoxyinosine. ADA is active both inside the cell and on the cell surface where it was found to interact with membrane ...
B. Kutryb-Zając, Paulina Mierzejewska, E. Slominska, R. Smolenski   +3 more
semanticscholar   +1 more source

Asymmetric dimerization of adenosine deaminase acting on RNA facilitates substrate recognition

Nucleic Acids Research, 2020
Adenosine deaminases acting on RNA (ADARs) are enzymes that convert adenosine to inosine in duplex RNA, a modification that exhibits a multitude of effects on RNA structure and function.
A. Thuy-Boun, Justin M. Thomas, Herra L. Grajo, Cody M. Palumbo, Sehee Park, L. T. Nguyen, A. Fisher, P. Beal   +7 more
semanticscholar   +1 more source

EFFECT OF SOME ANTIBIOTICS IN ACTIVITY OF ADENOSINE DEAMINASE IN SERUM [PDF]

مجلة جامعة الانبار للعلوم الصرفة, 2012
The aim of this study is to know the effect of same antibiotics such as tetracycline, benzyl pencillin and ampicillin on activity of adenosine deaminase (ADA) level in patients with brucellosis.
WESAM M. MOHAMMED ATEA
doaj   +1 more source

The ADA*2 allele of the adenosine deaminase gene (20q13.11) and recurrent spontaneous abortions: an age-dependent association

Clinics, 2011
OBJECTIVE: Adenosine deaminase acts on adenosine and deoxyadenosine metabolism and modulates the immune response. The adenosine deaminase G22A polymorphism (20q.11.33) influences the level of adenosine deaminase enzyme expression, which seems to play a ...
Daniela Prudente Teixeira Nunes, Lígia Cosentino Junqueira Franco Spegiorin, Cinara Cássia Brandão de Mattos, Antonio Helio Oliani, Denise Cristina Mós Vaz-Oliani, Luiz Carlos de Mattos   +5 more
doaj   +1 more source

Metabolic Aspects of Adenosine Functions in the Brain

Frontiers in Pharmacology, 2021
Adenosine, acting both through G-protein coupled adenosine receptors and intracellularly, plays a complex role in multiple physiological and pathophysiological processes by modulating neuronal plasticity, astrocytic activity, learning and memory, motor ...
Mercedes Garcia-Gil, Mercedes Garcia-Gil, Marcella Camici, Simone Allegrini, Rossana Pesi, Maria Grazia Tozzi   +5 more
doaj   +1 more source

Serum adenosine deaminase, catalase and carbonic anhydrase activities in patients with bladder cancer

Clinics, 2012
OBJECTIVES: The relationship between adenosine deaminase and various cancers has been investigated in several studies. However, serum adenosine deaminase activity and carbonic anhydrase and catalase activities in patients with bladder cancer have not ...
Necip Pirinççi, Ilhan Geçit, Mustafa Güneş, Mehmet Bilgehan Yüksel, Mehmet Kaba, Serhat Tanık, Halit Demir, Mehmet Aslan   +7 more
doaj   +1 more source

A novel mutation in the ADA gene causing severe combined immunodeficiency in an Arab patient: a case report

Journal of Medical Case Reports, 2009
Introduction About 20% of the cases of human severe combined immunodeficiency are the result of the child being homozygous for defective genes encoding the enzyme adenosine deaminase.
Hellani Ali, Almassri Nidal, Abu-Amero Khaled K   +2 more
doaj   +1 more source