Results 1 to 10 of about 1,280 (195)
Purinergic Signaling in the Regulation of Gout Flare and Resolution
Frontiers in Immunology, 2021 Gout flares require monosodium urate (MSU) to activate the NLRP3 inflammasome and secrete sufficient IL-1β. However, MSU alone is not sufficient to cause a flare. This is supported by the evidence that most patients with hyperuricemia do not develop gout
Xiaoling Li, Jie Gao, Jinhui Tao
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Platelet aggregation and von Willebrand factor in patients with artherial hypertension combined with osteoarthritis [PDF]
Ķazaķstannyṇ Klinikalyķ Medicinasy, 2017 Objective: To investigate the platelet aggregation and level of von Willebrand factor in patients with hypertension and knee osteoarthritis.
Viktoriya Rodionova, Olena Khmel
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Molbank, 2022 Cyclic adenosine diphosphate ribose (cADPR) is a cyclic nucleotide involved in the Ca2+ homeostasis. In its structure, the northern ribose, bonded to adenosine through an N1 glycosidic bond, is connected to the southern ribose through a pyrophosphate ...
Maria Marzano +5 more
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Adenosine diphosphate ribosylated histones [PDF]
Biochemical Journal, 1977 When rat liver nuclei were incubated with [adenine-3H]NAD, besides histone 1, histone 2A and especially histone 2B accepted 3H radioactivity. 3H radioactivity was also found on the non-histone proteins and on the small amounts of histones 1 and 3 released into the supernatant during incubation.
M G, Ord, L A, Stocken
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Structure/function analysis of PARP-1 in oxidative and nitrosative stress-induced monomeric ADPR formation. [PDF]
PLoS ONE, 2009 Poly adenosine diphosphate-ribose polymerase-1 (PARP-1) is a multifunctional enzyme that is involved in two major cellular responses to oxidative and nitrosative (O/N) stress: detection and response to DNA damage via formation of protein-bound poly ...
Ben Buelow +3 more
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An arsenical analogue of adenosine diphosphate [PDF]
Biochemical Journal, 1978 An analogue of ADP was made in which the terminal phosphono-oxy group, -O-PO(OH)2, has been replaced by the arsonomethyl group, -CH2-AsO(OH)2. This compound cannot form a stable analogue of ATP because anhydrides of arsonic acids are rapidly hydrolysed, so that any enzyme that phosphorylates ADP and accepts this analogue as a substrate should release ...
D, Webster, M J, Sparkes, H B, Dixon
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Haematologica, 2012 Background The interaction of adenosine diphosphate with its P2Y1 and P2Y12 receptors on platelets is important for platelet function. However, nothing is known about adenosine diphosphate and its function in human megakaryocytes.Design and Methods We ...
Alessandra Balduini +8 more
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Applied Sciences, 2021 The P2Y receptor family is a class of G protein-coupled receptors activated primarily by adenosine triphosphate (ATP), adenosine diphosphate (ADP), uridine triphosphate (UTP) and uridine diphosphate (UDP).
Lu Wang +6 more
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Signaling of the Purinergic System in the Joint
Frontiers in Pharmacology, 2020 The joint is a complex anatomical structure consisting of different tissues, each with a particular feature, playing together to give mobility and stability at the body.
Carmen Corciulo +3 more
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Clinical Implications of “Tailored” Antiplatelet Therapy in Patients With Chronic Total Occlusion
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020 Background Clopidogrel nonresponsiveness is a prognostic marker after percutaneous coronary intervention. Prasugrel and ticagrelor provide a better platelet inhibition and represent the first‐line antiplatelet treatment in acute coronary syndrome.
Maria Grazia De Gregorio +9 more
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