Poly(adenosine diphosphate ribose) polymerase inhibitors induce autophagy-mediated drug resistance in ovarian cancer cells, xenografts, and patient-derived xenograft models. [PDF]
Cancer, 2020 Poly(adenosine diphosphate ribose) polymerase (PARP) inhibitors exhibit promising activity against ovarian cancers, but their efficacy can be limited by acquired drug resistance.
Santiago-O'Farrill JM +17 more
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Expression of poly(Adenosine Diphosphate-Ribose) polymerase protein in breast cancer [PDF]
Journal of Mid-Life Health, 2022 Background: The use of poly(adenosine diphosphate-ribose) polymerase (PARP) inhibitors for breast cancer (BC) therapy is the subject of debate, and there is an urgent need to understand much the expression and prognostic role of the PARP1 protein.
Akanksha +6 more
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Haematologica, 2012 Background The interaction of adenosine diphosphate with its P2Y1 and P2Y12 receptors on platelets is important for platelet function. However, nothing is known about adenosine diphosphate and its function in human megakaryocytes.Design and Methods We ...
Alessandra Balduini +8 more
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O6-[(2″,3″-O-Isopropylidene-5″-O-tbutyldimethylsilyl)pentyl]-5′-O-tbutyldiphenylsilyl-2′,3′-O-isopropylideneinosine [PDF]
Molbank, 2022 Cyclic adenosine diphosphate ribose (cADPR) is a cyclic nucleotide involved in the Ca2+ homeostasis. In its structure, the northern ribose, bonded to adenosine through an N1 glycosidic bond, is connected to the southern ribose through a pyrophosphate ...
Maria Marzano +5 more
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Adenosine diphosphate and the measurement of platelet adhesiveness [PDF]
Journal of Clinical Pathology, 1967 Platelet adhesiveness to glass beads was measured in citrated blood at intervals up to two hours after the addition of adenosine diphosphate (A.D.P.). Adhesiveness increased for 15 minutes, fell towards the original level, and then steadily increased.
Arnold Bloom, Alison Davies
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The Impact of Cold Storage on Adenosine Diphosphate-Mediated Platelet Responsiveness [PDF]
TH Open, 2020 Introduction Cold storage of platelets is considered to contribute to lower risk of bacterial growth and to more efficient hemostatic capacity. For the optimization of storage strategies, it is required to further elucidate the influence of refrigeration
Juergen Koessler +6 more
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Extracellular Adenosine Diphosphate Stimulates CXCL10-Mediated Mast Cell Infiltration Through P2Y1 Receptor to Aggravate Airway Inflammation in Asthmatic Mice [PDF]
Frontiers in Molecular Biosciences, 2021 Asthma is an inflammatory disease associated with variable airflow obstruction and airway inflammation. This study aimed to explore the role and mechanism of extracellular adenosine diphosphate (ADP) in the occurrence of airway inflammation in asthma ...
Yan-Yan Gao, Zeng-Yan Gao
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Adenosine Diphosphate Glucose and Glucoside Biosynthesis [PDF]
Nature, 1962 URIDINE diphosphate glucose (UDPG) has been found to act as glucose donor in a number of enzymatic reactions, such as glucoside formation in plants1 and in locust2, sucrose and starch synthesis in plants3,4 and glycogen formation in mammals5.
Juan Carlos Trivelloni +2 more
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Purinergic Signaling in the Regulation of Gout Flare and Resolution
Frontiers in Immunology, 2021 Gout flares require monosodium urate (MSU) to activate the NLRP3 inflammasome and secrete sufficient IL-1β. However, MSU alone is not sufficient to cause a flare. This is supported by the evidence that most patients with hyperuricemia do not develop gout
Xiaoling Li, Jie Gao, Jinhui Tao
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Platelet aggregation and von Willebrand factor in patients with artherial hypertension combined with osteoarthritis [PDF]
Ķazaķstannyṇ Klinikalyķ Medicinasy, 2017 Objective: To investigate the platelet aggregation and level of von Willebrand factor in patients with hypertension and knee osteoarthritis.
Viktoriya Rodionova, Olena Khmel
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