Results 1 to 10 of about 1,145 (70)

Purinergic Signaling in the Regulation of Gout Flare and Resolution

Frontiers in Immunology, 2021
Gout flares require monosodium urate (MSU) to activate the NLRP3 inflammasome and secrete sufficient IL-1β. However, MSU alone is not sufficient to cause a flare. This is supported by the evidence that most patients with hyperuricemia do not develop gout
Xiaoling Li, Jie Gao, Jinhui Tao
doaj   +1 more source

Platelet aggregation and von Willebrand factor in patients with artherial hypertension combined with osteoarthritis [PDF]

Ķazaķstannyṇ Klinikalyķ Medicinasy, 2017
Objective: To investigate the platelet aggregation and level of von Willebrand factor in patients with hypertension and knee osteoarthritis.
Viktoriya Rodionova, Olena Khmel
doaj   +1 more source

O6-[(2″,3″-O-Isopropylidene-5″-O-^tbutyldimethylsilyl)pentyl]-5′-O-^tbutyldiphenylsilyl-2′,3′-O-isopropylideneinosine

Molbank, 2022
Cyclic adenosine diphosphate ribose (cADPR) is a cyclic nucleotide involved in the Ca2+ homeostasis. In its structure, the northern ribose, bonded to adenosine through an N1 glycosidic bond, is connected to the southern ribose through a pyrophosphate ...
Maria Marzano, Monica Terracciano, Vincenzo Piccialli, Ahmed Mahal, Roberto Nilo, Stefano D’Errico   +5 more
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Structure/function analysis of PARP-1 in oxidative and nitrosative stress-induced monomeric ADPR formation. [PDF]

PLoS ONE, 2009
Poly adenosine diphosphate-ribose polymerase-1 (PARP-1) is a multifunctional enzyme that is involved in two major cellular responses to oxidative and nitrosative (O/N) stress: detection and response to DNA damage via formation of protein-bound poly ...
Ben Buelow, Burak Uzunparmak, Marcia Paddock, Andrew M Scharenberg   +3 more
doaj   +1 more source

Constitutively released adenosine diphosphate regulates proplatelet formation by human megakaryocytes

Haematologica, 2012
Background The interaction of adenosine diphosphate with its P2Y1 and P2Y12 receptors on platelets is important for platelet function. However, nothing is known about adenosine diphosphate and its function in human megakaryocytes.Design and Methods We ...
Alessandra Balduini, Christian Andrea Di Buduo, Alessandro Malara, Anna Lecchi, Paola Rebuzzini, Manuela Currao, Isabella Pallotta, Joseph A. Jakubowski, Marco Cattaneo   +8 more
doaj   +1 more source

The Role and Molecular Mechanism of P2Y12 Receptors in the Pathogenesis of Atherosclerotic Cardiovascular Diseases

Applied Sciences, 2021
The P2Y receptor family is a class of G protein-coupled receptors activated primarily by adenosine triphosphate (ATP), adenosine diphosphate (ADP), uridine triphosphate (UTP) and uridine diphosphate (UDP).
Lu Wang, Jinxuan Wang, Jianxiong Xu, Weixi Qin, Yuming Wang, Shisui Luo, Guixue Wang   +6 more
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Signaling of the Purinergic System in the Joint

Frontiers in Pharmacology, 2020
The joint is a complex anatomical structure consisting of different tissues, each with a particular feature, playing together to give mobility and stability at the body.
Carmen Corciulo, Carmen Corciulo, Bruce N. Cronstein, Bruce N. Cronstein   +3 more
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Clinical Implications of “Tailored” Antiplatelet Therapy in Patients With Chronic Total Occlusion

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background Clopidogrel nonresponsiveness is a prognostic marker after percutaneous coronary intervention. Prasugrel and ticagrelor provide a better platelet inhibition and represent the first‐line antiplatelet treatment in acute coronary syndrome.
Maria Grazia De Gregorio, Rossella Marcucci, Angela Migliorini, Anna Maria Gori, Betti Giusti, Ruben Vergara, Rita Paniccia, Nazario Carrabba, Niccolò Marchionni, Renato Valenti   +9 more
doaj   +1 more source

Determination of Adenylate Nucleotides in Amphipod Gammarus fossarum by Ion-Pair Reverse Phase Liquid Chromatography: Possibilities of Positive Pressure Micro-Solid Phase Extraction

Separations, 2021
Adenine nucleotides—adenosine monophosphate, diphosphate, and triphosphate—are of utmost importance to all living organisms, where they play a critical role in the energy metabolism and are tied to allosteric regulation in various regulatory enzymes ...
Zuzana Redžović, Marijana Erk, Ema Svetličić, Lucija Dončević, Sanja Gottstein, Amela Hozić, Mario Cindrić   +6 more
doaj   +1 more source

Platelet aggregation and quality control of platelet concentrates produced in the Amazon Blood Bank

Revista Brasileira de Hematologia e Hemoterapia, 2011
BACKGROUND: The study of platelet aggregation is essential to assess in vitro platelet function by different platelet activation pathways. OBJECTIVE: To assess aggregation and biochemical parameters of random platelet concentrates produced at the ...
Maria José Dantas Coêlho, Taysa de Castro Monteiro, Felicien Gonçalves Vasquez, Kátia Luz Torres Silva, Kleber Sandro Brasil dos Santos, Viviana Maria Araújo de Oliveira, Francimary de Oliveira Cavalcante   +6 more
doaj   +1 more source