Results 1 to 10 of about 299,626 (358)

A pan-tumor review of the role of poly(adenosine diphosphate ribose) polymerase inhibitors. [PDF]

CA Cancer J Clin
Poly(adenosine diphosphate ribose) polymerase (PARP) inhibitors, such as olaparib, talazoparib, rucaparib, and niraparib, comprise a therapeutic class that targets PARP proteins involved in DNA repair.
Hage Chehade C, Gebrael G, Sayegh N, Ozay ZI, Narang A, Crispino T, Golan T, Litton JK, Swami U, Moore KN, Agarwal N.   +10 more
europepmc   +2 more sources

Constitutively released adenosine diphosphate regulates proplatelet formation by human megakaryocytes

Haematologica, 2012
Background The interaction of adenosine diphosphate with its P2Y1 and P2Y12 receptors on platelets is important for platelet function. However, nothing is known about adenosine diphosphate and its function in human megakaryocytes.Design and Methods We ...
Alessandra Balduini, Christian Andrea Di Buduo, Alessandro Malara, Anna Lecchi, Paola Rebuzzini, Manuela Currao, Isabella Pallotta, Joseph A. Jakubowski, Marco Cattaneo   +8 more
doaj   +2 more sources

Poly(adenosine diphosphate ribose) polymerase inhibitors induce autophagy-mediated drug resistance in ovarian cancer cells, xenografts, and patient-derived xenograft models. [PDF]

Cancer, 2020
Poly(adenosine diphosphate ribose) polymerase (PARP) inhibitors exhibit promising activity against ovarian cancers, but their efficacy can be limited by acquired drug resistance.
Santiago-O'Farrill JM, Weroha SJ, Hou X, Oberg AL, Heinzen EP, Maurer MJ, Pang L, Rask P, Amaravadi RK, Becker SE, Romero I, Rubio MJ, Matias-Guiu X, Santacana M, Llombart-Cussac A, Poveda A, Lu Z, Bast RC.   +17 more
europepmc   +2 more sources

Expression of poly(Adenosine Diphosphate-Ribose) polymerase protein in breast cancer [PDF]

Journal of Mid-Life Health, 2022
Background: The use of poly(adenosine diphosphate-ribose) polymerase (PARP) inhibitors for breast cancer (BC) therapy is the subject of debate, and there is an urgent need to understand much the expression and prognostic role of the PARP1 protein.
Akanksha, Shashi Prakash Mishra, Amrita Ghosh Kar, J S Karthik, Aviral Srivastava, Rahul Khanna, Ram Niwas Meena   +6 more
doaj   +2 more sources

Association of Bleeding Scores and Platelet Transfusions With Platelet Counts and Closure Times in Response to Adenosine Diphosphate (CT-ADPs) Among Preterm Neonates With Thrombocytopenia.

JAMA Netw Open, 2020
This cohort study analyzes the association of closure time in response to adenosine diphosphate (CT-ADP) with bleeding score and the associations of platelet transfusions with change in platelet count, CT-ADP, and bleeding scores in preterm neonates with
Deschmann E, Saxonhouse MA, Feldman HA, Norman M, Barbian M, Sola-Visner M.   +5 more
europepmc   +2 more sources

The Impact of Cold Storage on Adenosine Diphosphate-Mediated Platelet Responsiveness [PDF]

TH Open, 2020
Introduction Cold storage of platelets is considered to contribute to lower risk of bacterial growth and to more efficient hemostatic capacity. For the optimization of storage strategies, it is required to further elucidate the influence of refrigeration
Juergen Koessler, Philipp Klingler, Marius Niklaus, Katja Weber, Angela Koessler, Markus Boeck, Anna Kobsar   +6 more
doaj   +2 more sources

Динамические способности и управление качеством [PDF]

Anesthesiology, 2008
BACKGROUND: Mechanical ventilation can induce organ injury associated with overwhelming inflammatory responses. Excessive activation of poly(adenosine diphosphate-ribose) polymerase enzyme following massive DNA damage may aggravate inflammatory responses.
Chiang, Shyh Ren, Della Corte, Francesco, Haitsma, Jack J., Juco, Jonathan W., Kuiper, Jan W., Plötz, Frans B., Slutsky, Arthur S., Uhlig, Stefan, Vaschetto, Rosanna, Zhang, Haibo   +9 more
core   +3 more sources

Adenosine Diphosphate Measurement [PDF]

Definitions, 2020
openaire   +2 more sources

Azulene-based fluorescent chemosensor for adenosine diphosphate.

Chemical Communications, 2021
AzuFluor® 435-DPA-Zn, an azulene fluorophore bearing two zinc(II)-dipicolylamine receptor motifs, exhibits fluorescence enhancement in the presence of adenosine diphosphate.
Carlos M López-Alled, Sang-Jun Park, Dong Joon Lee, Lloyd C Murfin, G. Kociok‐Köhn, Jodie L. Hann, J. Wenk, T. James, H. Kim, S. Lewis   +9 more
semanticscholar   +1 more source

Purinergic Signaling in the Regulation of Gout Flare and Resolution

Frontiers in Immunology, 2021
Gout flares require monosodium urate (MSU) to activate the NLRP3 inflammasome and secrete sufficient IL-1β. However, MSU alone is not sufficient to cause a flare. This is supported by the evidence that most patients with hyperuricemia do not develop gout
Xiaoling Li, Jie Gao, Jinhui Tao
doaj   +1 more source