Results 1 to 10 of about 102,235 (302)

Expression of poly(Adenosine Diphosphate-Ribose) polymerase protein in breast cancer [PDF]

Journal of Mid-Life Health, 2022
Background: The use of poly(adenosine diphosphate-ribose) polymerase (PARP) inhibitors for breast cancer (BC) therapy is the subject of debate, and there is an urgent need to understand much the expression and prognostic role of the PARP1 protein.
Akanksha, Shashi Prakash Mishra, Amrita Ghosh Kar, J S Karthik, Aviral Srivastava, Rahul Khanna, Ram Niwas Meena   +6 more
doaj   +2 more sources

The Impact of Cold Storage on Adenosine Diphosphate-Mediated Platelet Responsiveness [PDF]

TH Open, 2020
Introduction Cold storage of platelets is considered to contribute to lower risk of bacterial growth and to more efficient hemostatic capacity. For the optimization of storage strategies, it is required to further elucidate the influence of refrigeration
Juergen Koessler, Philipp Klingler, Marius Niklaus, Katja Weber, Angela Koessler, Markus Boeck, Anna Kobsar   +6 more
doaj   +2 more sources

Purinergic Signaling in the Regulation of Gout Flare and Resolution

Frontiers in Immunology, 2021
Gout flares require monosodium urate (MSU) to activate the NLRP3 inflammasome and secrete sufficient IL-1β. However, MSU alone is not sufficient to cause a flare. This is supported by the evidence that most patients with hyperuricemia do not develop gout
Xiaoling Li, Jie Gao, Jinhui Tao
doaj   +1 more source

Platelet aggregation and von Willebrand factor in patients with artherial hypertension combined with osteoarthritis [PDF]

Ķazaķstannyṇ Klinikalyķ Medicinasy, 2017
Objective: To investigate the platelet aggregation and level of von Willebrand factor in patients with hypertension and knee osteoarthritis.
Viktoriya Rodionova, Olena Khmel
doaj   +1 more source

O6-[(2″,3″-O-Isopropylidene-5″-O-^tbutyldimethylsilyl)pentyl]-5′-O-^tbutyldiphenylsilyl-2′,3′-O-isopropylideneinosine

Molbank, 2022
Cyclic adenosine diphosphate ribose (cADPR) is a cyclic nucleotide involved in the Ca2+ homeostasis. In its structure, the northern ribose, bonded to adenosine through an N1 glycosidic bond, is connected to the southern ribose through a pyrophosphate ...
Maria Marzano, Monica Terracciano, Vincenzo Piccialli, Ahmed Mahal, Roberto Nilo, Stefano D’Errico   +5 more
doaj   +1 more source

Adenosine diphosphate ribosylated histones [PDF]

Biochemical Journal, 1977
When rat liver nuclei were incubated with [adenine-3H]NAD, besides histone 1, histone 2A and especially histone 2B accepted 3H radioactivity. 3H radioactivity was also found on the non-histone proteins and on the small amounts of histones 1 and 3 released into the supernatant during incubation.
M G, Ord, L A, Stocken
openaire   +2 more sources

Structure/function analysis of PARP-1 in oxidative and nitrosative stress-induced monomeric ADPR formation. [PDF]

PLoS ONE, 2009
Poly adenosine diphosphate-ribose polymerase-1 (PARP-1) is a multifunctional enzyme that is involved in two major cellular responses to oxidative and nitrosative (O/N) stress: detection and response to DNA damage via formation of protein-bound poly ...
Ben Buelow, Burak Uzunparmak, Marcia Paddock, Andrew M Scharenberg   +3 more
doaj   +1 more source

The Role and Molecular Mechanism of P2Y12 Receptors in the Pathogenesis of Atherosclerotic Cardiovascular Diseases

Applied Sciences, 2021
The P2Y receptor family is a class of G protein-coupled receptors activated primarily by adenosine triphosphate (ATP), adenosine diphosphate (ADP), uridine triphosphate (UTP) and uridine diphosphate (UDP).
Lu Wang, Jinxuan Wang, Jianxiong Xu, Weixi Qin, Yuming Wang, Shisui Luo, Guixue Wang   +6 more
doaj   +1 more source

Constitutively released adenosine diphosphate regulates proplatelet formation by human megakaryocytes

Haematologica, 2012
Background The interaction of adenosine diphosphate with its P2Y1 and P2Y12 receptors on platelets is important for platelet function. However, nothing is known about adenosine diphosphate and its function in human megakaryocytes.Design and Methods We ...
Alessandra Balduini, Christian Andrea Di Buduo, Alessandro Malara, Anna Lecchi, Paola Rebuzzini, Manuela Currao, Isabella Pallotta, Joseph A. Jakubowski, Marco Cattaneo   +8 more
doaj   +1 more source

Signaling of the Purinergic System in the Joint

Frontiers in Pharmacology, 2020
The joint is a complex anatomical structure consisting of different tissues, each with a particular feature, playing together to give mobility and stability at the body.
Carmen Corciulo, Carmen Corciulo, Bruce N. Cronstein, Bruce N. Cronstein   +3 more
doaj   +1 more source