Results 31 to 40 of about 163,297 (275)

Inhibition of Gastric Erosion Formations in Rats by Adenosine, 5 /-Adenosine Monophosphate and 5 /- Adenosine Diphosphate [PDF]

, 2009
Gastric erosions were induced in rats with indomethacin, 5-hydoxytryptamine (5-HT) or reserpine. Three adenine compounds adenosine, adenosine, 5 /-adenosine monophosphate (AMP) and 5 /- adenosine diphosphate (ADP) were found to protect against the ...
Nwodo, OFC, CI Ezekwe, CA Anosike, OFC Nwodo, Ezekwe, CI, Anosike, CA   +5 more
core   +1 more source

The role of ectonucleotidases CD39 and CD73 and adenosine signalling in solid organ transplantation

Frontiers in Immunology, 2014
Extracellular adenosine is a potent immunomodulatory molecule that accumulates in states of inflammation. Nucleotides such as adenosine triphosphate (ATP) and adenosine diphosphate (ADP) are release from injured and necrotic cells and hydrolysed to ...
Veena eRoberts, John eStagg, Karen M Dwyer   +2 more
doaj   +1 more source

The ART of tumor immune escape

OncoImmunology, 2022
We recently identified the adenosine-5′-diphosphate (ADP)–ribosyltransferase-1 (ART1) as a novel immune checkpoint expressed by cancer cells. ART1 utilizes free nicotinamide adenine dinucleotide (NAD+) in the tumor microenvironment (TME) to mono-ADP ...
Erik Wennerberg, Sumit Mukherjee, Ricardo M. Sainz, Brendon M. Stiles   +3 more
doaj   +1 more source

Theranostic Potential of an NAD(P)H‐Activatable Fluorophore: Assessing Cancer Aggressiveness and Triggering Apoptosis

Angewandte Chemie, EarlyView.
DE‐CQ, an NAD(P)H‐activatable theranostic probe, enables the quantification of cancer aggressiveness via glucose‐stimulated fluorescence imaging and selectively induces apoptosis. Its multifaceted efficacy is demonstrated across 2D cells, 3D spheroids, and in vivo models.
Yujin Cha, Taehoon Oh, Hui Joo Kim, Minju Kang, Shin A Yoon, Yul Lee, Yeon‐Ju Lee, Sun Young Park, Dong‐Sik Shin, Sung‐Kyun Ko, Jiyou Han, Min Hee Lee   +11 more
wiley   +2 more sources

ANALYSIS OF THE STATE OF PLATELET AGGREGATION IN PREGNANT WOMEN WITH THROMBOPHILIA AND BURDENED OBSTETRIC HISTORY

Східноукраїнський медичний журнал, 2021
The analysis of platelet aggregation in pregnant women with thrombophilia and burdened obstetric history was performed. It has been determined that the development of adverse effects of pregnancy is significantly influenced by conditions such as ...
Olha I. Zalyubovska, Valeriya V. Hryshchenko   +1 more
doaj   +1 more source

Free Adenosine Diphosphate as an Intermediary in the Phosphorylation by Creatine Phosphate of Adenosine Diphosphate Bound to Actin

Journal of Biological Chemistry, 1967
Abstract Pretreatment of adenosine diphosphate-G-actin solutions with apyrase results in a marked decrease in their rate of polymerization at 0° induced by KCl, creatine phosphate, and creatine kinase. In contrast, apyrase has no effect on the rate of polymerization of ATP-G-actin.
J J, West, B, Nagy, J, Gergely
openaire   +2 more sources

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Elevated ecto-5′-nucleotidase: a missing pathogenic factor and new therapeutic target for sickle cell disease

Blood Advances, 2018
: Although excessive plasma adenosine is detrimental in sickle cell disease (SCD), the molecular mechanism underlying elevated circulating adenosine remains unclear.
Hong Liu, Morayo Adebiyi, Rong Rong Liu, Anren Song, Jeanne Manalo, Yuan Edward Wen, Alexander Q. Wen, Tingting Weng, Junsuk Ko, Modupe Idowu, Rodney E. Kellems, Holger K. Eltzschig, Michael R. Blackburn, Harinder S. Juneja, Yang Xia   +14 more
doaj   +1 more source

Type III effector activation via nucleotide binding, phosphorylation, and host target interaction. [PDF]

PLoS Pathogens, 2007
The Pseudomonas syringae type III effector protein avirulence protein B (AvrB) is delivered into plant cells, where it targets the Arabidopsis RIN4 protein (resistance to Pseudomonas maculicula protein 1 [RPM1]-interacting protein).
Darrell Desveaux, Alex U Singer, Ai-Jiuan Wu, Brian C McNulty, Laura Musselwhite, Zachary Nimchuk, John Sondek, Jeffery L Dangl   +7 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source