Results 91 to 100 of about 53,776 (165)

Acute Lung Injury: From Molecular Circuits to System‐Level Therapeutics

MedComm, Volume 7, Issue 6, June 2026.
This visual summary illustrates the paradigm shift from linear pathways to network medicine in ALI. Three interconnected circuits—innate immunity, immunometabolism, and cell death (PANoptosis)—drive disease progression under multiorgan crosstalk (gut–lung, brain–lung).
Yaoli Hou, Sheng He, Lili He, Kun Liu, Wen Tang, Deming Wang, Jing Gui, Zhiying Zeng, Yan Wang, Wenjie Liu, Ren Jing   +10 more
wiley   +1 more source

Adenosine diphosphate released from stressed cells triggers mitochondrial transfer to achieve tissue homeostasis. [PDF]

PLoS Biol
Li H, Yu H, Liu D, Liao P, Gao C, Zhou J, Mei J, Zong Y, Ding P, Yao M, Wang B, Lu Y, Huang Y, Gao Y, Zhang C, Zheng M, Gao J.   +16 more
europepmc   +1 more source

Poly(Adenosine Diphosphate Ribose) Polymerase (PARP) Inhibitors in the Treatment of Advanced Ovarian Cancer: A Narrative Review. [PDF]

Cureus
Dewani D, Jaiswal A, Karwade P.
europepmc   +1 more source

Serum Amyloid β Oligomer May Predict Treatment Response in Middle‐Aged and Late‐Life Patients With Depression

Neuropsychopharmacology Reports, Volume 46, Issue 2, June 2026.
After 4 weeks of antidepressant treatment, patients with serum amyloid β oligomers showed a significantly lower treatment response compared with those without Aβ oligomers among middle‐aged and late‐life patients with major depressive disorder. ABSTRACT Aim Late‐life patients with depression are reportedly less responsive to antidepressant treatment ...
Kentaro Shimizu, Seita Yasuda, Hitoshi Maeshima, Tomoya Ichikawa, Hajime Baba   +4 more
wiley   +1 more source

A switch-on luminescent europium(iii) probe for selective and time-resolved detection of adenosine diphosphate (ADP). [PDF]

Chem Sci
Bodman SE, Stachelek P, Rehman U, Plasser F, Pal R, Butler SJ.   +5 more
europepmc   +1 more source

Dynamic disorder is crucial for mitochondrial protein import

Protein Science, Volume 35, Issue 6, June 2026.
Abstract The import of proteins into mitochondria poses fundamental mechanistic challenges: aggregation‐prone precursor proteins must be maintained in aqueous compartments and threaded through narrow pores without becoming stuck or mislocalized. Recent evidence from mitochondrial protein import studies and other chaperone systems underscores the ...
Jakob Schneider, Undina Guillerm, Caroline Simões Pereira, Paul Schanda   +3 more
wiley   +1 more source

Influence of Magnesium Ion Binding on the Adenosine Diphosphate Structure and Dynamics, Investigated by ³¹P NMR and Molecular Dynamics Simulations. [PDF]

J Phys Chem B
Marr KA, Korenchan DE, Jerschow A.
europepmc   +1 more source

[Poly adenosine diphosphate-ribosylation and neurodegenerative diseases]. [PDF]

Zhejiang Da Xue Xue Bao Yi Xue Ban, 2020
Wang Y, Lu Y.
europepmc   +1 more source

Loss of SMARCAD1 Mitigates Tauopathy

Aging Cell, Volume 25, Issue 6, June 2026.
Using genetics approaches in a C. elegans transgenic model of tauopathy, we uncover a role for the homolog of human SMARCAD1, a regulator of chromatin dynamics. ABSTRACT Tauopathies are neurodegenerative diseases characterized by the accumulation of misfolded tau protein and include Alzheimer's disease (AD) and related dementia disorders.
Vaishnavi S. Jadhav, Rebecca L. Kow, Asia D. Beale, Misa Baum, Pamela J. McMillan, Caitlin S. Latimer, Nicole F. Liachko, Brian C. Kraemer   +7 more
wiley   +1 more source

Kinetic Analysis and Metabolism of Poly(Adenosine Diphosphate-Ribose) Polymerase-1-Targeted ¹⁸F-Fluorthanatrace PET in Breast Cancer. [PDF]

J Nucl Med
Young AJ, Pantel AR, Kiani M, Doot RK, Bagheri S, Pryma DA, Farwell MD, Li S, Lee H, Schubert EK, Secreto A, Zuckerman SP, Nayak A, Choi H, Carlin S, DeMichele A, Mankoff DA, Zhou R, Mach RH, McDonald ES.   +19 more
europepmc   +1 more source