Results 81 to 90 of about 53,776 (165)

Astrocytic Mitochondria Transplantation Rescues Neuron Loss and Dendritic Injuries in Acute Cerebral Ischemic Stroke Mouse Model by Flexibly Regulating Mitochondria Dynamics

Annals of Neurology, Volume 99, Issue 6, Page 1571-1588, June 2026.
Objective Cerebral ischemic stroke causes neuronal oxygen/energy deprivation, disrupting mitochondrial function including reduced membrane potential and bioenergetics, exacerbating neuronal injury. Mitochondrial defects are, therefore, a central neuropathological node and potential therapeutic target.
Ning Bian, Jianing Shen, Linwei Tian, Jinghui Li, Lu Yang, Bo Yuan, Shulin Li, Yuyu Niu, Lu Zhao, Jingkuan Wei   +9 more
wiley   +1 more source

Model for Predicting Serious Hematological Adverse Events in Individuals With Ovarian Cancer Receiving Poly (Adenosine Diphosphate Ribose) Polymerase Inhibitor Treatment: Prospective Cohort Study. [PDF]

JMIR Med Inform
Lian X, Lei Y.
europepmc   +1 more source

Bibliometric Analysis of Cubebenes and Related Sesquiterpenes: Natural Occurrence, Biosynthesis, Pharmacological Activities, and In‐Silico‐Based Future Therapeutic Potential

eFood, Volume 7, Issue 3, June 2026.
Cubebene‐related sesquiterpenes, found across diverse biological sources, exhibit promising pharmacological activities, including anti‐inflammatory, neuroprotective, and anticancer effects. This review highlights their molecular diversity, ADME profiles, and predicted multitarget interactions, underscoring their therapeutic relevance and potential in ...
Khadija Boualam, Ahmet B. Ortaakarsu, Sohaib Khatib, Mohamed A. Farag, Mansour Sobeh   +4 more
wiley   +1 more source

Platelet reactivity to adenosine diphosphate and <i>CYP2C19</i> genotypes are linked with carotid plaques and may predict carotid plaque stability in acute ischemic stroke patients. [PDF]

Neurosciences (Riyadh)
Shi H, Tang M, Wang T, Yang L, Lai X, Chen Y, Diao F, Chen X, Zuo J, Xu J, Zhong G, Dong Y.   +11 more
europepmc   +1 more source

Occurrence of Pancytopenia Among Patients With Cancer Treated With Poly(Adenosine Diphosphate-Ribose) Polymerase Inhibitors: A Pharmacoepidemiologic Study.

JAMA Oncol, 2021
Morice PM, Chrétien B, Da Silva A, Dolladille C, Alexandre J.   +4 more
europepmc   +1 more source

Patient cost sharing during poly(adenosine diphosphate-ribose) polymerase inhibitor treatment in ovarian cancer. [PDF]

Am J Obstet Gynecol, 2021
Harrison RF, Fu S, Sun CC, Zhao H, Lu KH, Giordano SH, Meyer LA.   +6 more
europepmc   +1 more source

Assessing Functional Recovery in Ischemic Stroke: An Observational Study of Dual vs. Single Antiplatelet Therapy in Indian Patients

Health Science Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Background and Aim In an aging population, stroke is a leading cause of morbidity and mortality. More than 80% of stroke cases in the elderly are ischemic strokes. Stroke is the sixth most common cause of disability globally and the second most common cause after ischemic heart disease (IHD).
Sohailuddin Mohammad, Hemaakshi Gupta, Dipinder Deep Bhat, Tirunagari Navya Sree, Anveshak, Summaiah Asim, Mohammed Faizan Ahmed, Pooja Pancholi, Younes Nabgouri, Mohammed Abdul Mateen, Nagham Al Dirani   +10 more
wiley   +1 more source

First-in-Human Phase 1 Study to Evaluate the Clinical Pharmacology Properties of RBN-3143, a Novel Inhibitor of Mono-Adenosine Diphosphate Ribosyltransferase-PARP14. [PDF]

Clin Pharmacol Drug Dev
Polasek TM, Cole A, Bozón V, Manyak E, Novak J, Yang B, Johnston BA, Parasuraman S, Paneliya KJ, Schuck V.   +9 more
europepmc   +1 more source

The Role of N6‐Methyladenosine Modification in Health and Disease

MedComm, Volume 7, Issue 6, June 2026.
N6‐methyladenosine (m6A) is the most prevalent internal RNA modification in eukaryotes, acting as a pivotal epitranscriptomic regulator of RNA metabolism. This modification plays a dual role: it maintains physiological homeostasis under normal conditions but drives disease progression when dysregulated.
Linghuan Li, Yuanhai Sun, Wanfang Zheng, Lingqin Li, Yaqian Feng, Minyou Qi, Hanbing Li   +6 more
wiley   +1 more source

Adenosine diphosphate stimulates VEGF-independent choroidal endothelial cell proliferation: A potential escape from anti-VEGF therapy. [PDF]

Proc Natl Acad Sci U S A
Biswas N, Mori T, Ragava Chetty Nagaraj NK, Xin H, Diemer T, Li P, Su Y, Piermarocchi C, Ferrara N.   +8 more
europepmc   +1 more source