Results 171 to 180 of about 90,132 (350)

BRCA Mutation Testing in Men with Metastatic Castration‐Resistant Prostate Cancer: Practical Guidance for Australian Clinical Practice

open access: yesAsia-Pacific Journal of Clinical Oncology, EarlyView.
Molecular diagnostic testing identified mCRPC patients with BRCA mutations eligible for targeted therapies. Testing success is often contingent on the quality of tissue handling and laboratory processing techniques to minimize DNA degradation and suboptimal sequencing data quality.
Arun A. Azad   +4 more
wiley   +1 more source

Poly Adenosine Diphosphate-Ribose Polymerase (PARP) Inhibitors in Pancreatic Cancer. [PDF]

open access: yesCureus, 2022
Sunkara T   +5 more
europepmc   +1 more source

Cellular calcification induced by inorganic polyphosphate involves ATP depletion and opening of the mitochondrial permeability transition pore (mPTP)

open access: yesFEBS Open Bio, 2019
Inorganic polyphosphate (polyP) is a linear polymer containing tens to hundreds of orthophosphate residues linked by high‐energy phosphoanhydride bonds. PolyP promotes osteocalcification and bone mineralization in both mouse and human osteoblastic cells.
Kaori Tsutsumi, Tatsuya Sasase
doaj   +1 more source

Targeting the Galectin‐7/TRPM2/Zn2+/DRP‐1 Signaling Pathway: A Potential Therapeutic Intervention in the Pathogenesis of SJS/TEN

open access: yesAllergy, EarlyView.
This study investigates the role of mitochondrial fission in keratinocyte apoptosis in blister fluid‐derived exosomes from patients with SJS/TEN, erythema multiforme, and in healthy individuals. Galectin‐7 is upregulated in exosomes of patients with SJS/TEN and shows a correlation with disease severity.
Chen Zhang   +16 more
wiley   +1 more source

Molecular and cellular mechanisms underlying gyrate atrophy: Why is the retina primarily affected?

open access: yesActa Ophthalmologica, EarlyView.
Abstract Gyrate atrophy of the choroid and retina (GACR; OMIM #258870) is a rare early‐onset autosomal recessive disorder, caused by bi‐allelic pathogenic variants in the gene coding for ornithine aminotransferase (OAT) resulting in hyperornithinaemia.
Mark J. N. Buijs   +12 more
wiley   +1 more source

Graph‐based algorithms to dissect long‐distance water‐mediated H‐bond networks for conformational couplings in GPCRs

open access: yesBritish Journal of Pharmacology, EarlyView.
Graph‐based algorithms that enable efficient computations of all H‐bonds present in structures in entire datasets allow us to dissect H‐bond fingerprints that characterize distinct GPCRs and the structures sampled along their activation. Abstract Changes in structure and dynamics elicited by agonist ligand binding at the extracellular side of G protein
Éva Bertalan   +3 more
wiley   +1 more source

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